{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:40:17Z","timestamp":1775472017286,"version":"3.50.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Noninvasive ventilation (NIV) plays an important role in avoiding endotracheal intubation during myasthenic crisis, yet there are few published data concerning long-term home NIV in stable out-patients with myasthenia gravis (MG). The aim of this study was to describe the prevalence of NIV in a cohort of subjects with stable MG and to analyze contributing factors that could predict the need of NIV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We performed a cross-sectional study that included subjects diagnosed with MG managed in the respiratory care unit over the previous year. Subjects underwent clinical analysis including demographic, clinical, and functional respiratory data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Of the 50 subjects included, 35 (70%) were positive for nicotinic acetylcholine receptor antibodies, and 68% had a diagnosis of generalized MG. Bulbar symptoms developed in 16 (32%), and 10 (20%) subjects needed long-term home NIV. The only variable predicting the need for long-term NIV was MG severity measured with Myasthenia Gravis Foundation of America (MGFA), mainly grades IIB (odds ratio 0.14 [95% CI 0.02\u20130.85],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03) and IIIB (odds ratio 0.02 [95% CI 0.01\u20130.34],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Home NIV was needed in a substantial percentage of medically stable subjects with MG, mainly in those with generalized type and with oropharyngeal and\/or respiratory muscle involvement (MGFA grades IIB and IIIB).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.11308","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T11:27:50Z","timestamp":1699356470000},"page":"333-338","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Home Noninvasive Ventilation in Myasthenia Gravis"],"prefix":"10.1177","volume":"69","author":[{"given":"Jes\u00fas","family":"Sancho","sequence":"first","affiliation":[{"name":"Drs Sancho, Ferrer, Quezada, and Gimenez are affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; and Institute of Health Research INCLIVA, Valencia, Spain. Dr signes-costa is affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; Institute of Health Research INCLIVA, Valencia, Spain; and University of Valencia, Valencia, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santos","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Drs Sancho, Ferrer, Quezada, and Gimenez are affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; and Institute of Health Research INCLIVA, Valencia, Spain. Dr signes-costa is affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; Institute of Health Research INCLIVA, Valencia, Spain; and University of Valencia, Valencia, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Quezada","sequence":"additional","affiliation":[{"name":"Drs Sancho, Ferrer, Quezada, and Gimenez are affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; and Institute of Health Research INCLIVA, Valencia, Spain. Dr signes-costa is affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; Institute of Health Research INCLIVA, Valencia, Spain; and University of Valencia, Valencia, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia","family":"Gimenez","sequence":"additional","affiliation":[{"name":"Drs Sancho, Ferrer, Quezada, and Gimenez are affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; and Institute of Health Research INCLIVA, Valencia, Spain. Dr signes-costa is affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; Institute of Health Research INCLIVA, Valencia, Spain; and University of Valencia, Valencia, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Signes-Costa","sequence":"additional","affiliation":[{"name":"Drs Sancho, Ferrer, Quezada, and Gimenez are affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; and Institute of Health Research INCLIVA, Valencia, Spain. Dr signes-costa is affiliated with Respiratory Medicine Department, Hospital Cl\u00ednico Universitario, Valencia, Spain; Institute of Health Research INCLIVA, Valencia, Spain; and University of Valencia, Valencia, Spain."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112235"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)05186-2"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a41211"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008688"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000033797.79530.16"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.1"},{"issue":"4","key":"e_1_3_2_8_2","first-page":"189","article-title":"The effectiveness of noninvasive ventilation in myasthenia gravis subjects with respiratory failure in reducing the need of endotracheal intubation and increase extubation outcomes","volume":"22","author":"Farhana N","year":"2019","unstructured":"Farhana N, , Amin Z. The effectiveness of noninvasive ventilation in myasthenia gravis subjects with respiratory failure in reducing the need of endotracheal intubation and increase extubation outcomes. Crit Care Shock, 2019; 22(4):189\u2013196.","journal-title":"Crit Care Shock"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2021.08.008"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2016.11.015"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2003.08.002"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000074"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(05)70326-4"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05689"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011124"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.1.16"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1183\/09041950.005s1693"},{"issue":"5","key":"e_1_3_2_18_2","first-page":"696","article-title":"Maximal respiratory pressures: normal values and relationship to age and sex","volume":"99","author":"Black LF","year":"1969","unstructured":"Black LF, , Hyatt RE. 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