{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:43:41Z","timestamp":1785825821623,"version":"3.56.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T00:00:00Z","timestamp":1724457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      When treating acute respiratory failure, both hypoxemia and hyperoxemia should be avoided. S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      should be monitored closely and O\n                      <jats:sub>2<\/jats:sub>\n                      flows adjusted accordingly. Achieving this goal might be easier with automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration compared with manual titration of fixed-flow O\n                      <jats:sub>2<\/jats:sub>\n                      . We evaluated the feasibility of using an automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration device in subjects treated for acute hypoxemic respiratory failure in a tertiary care hospital.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Health-care workers received education and training about oxygen therapy, and were familiarized with an automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration device (FreeO\n                      <jats:sub>2,<\/jats:sub>\n                      ). A coordinator was available from 8:00\n                      <jats:sc>am<\/jats:sc>\n                      to 5:00\n                      <jats:sc>pm<\/jats:sc>\n                      during weekdays to provide technical assistance. The ability of the device to maintain S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      within the prescribed therapeutic window was recorded. Basic clinical information was recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Subjects were enrolled from November 2020 to August 2022. We trained 508 health-care workers on the use of automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration, which was finally used on 872 occasions in 763 subjects, distributed on the respiratory, COVID-19, and thoracic surgery wards, and in the emergency department. Clinical information could be retrieved for 609 subjects (80%) who were on the system for a median (interquartile range) of 3 (2-6) d, which represented 2,567 subject-days of clinical experience with the device. In the 82 subjects (14%) for whom this information was available, the system maintained S\n                      <jats:sub>\n                        pO\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:sub>\n                      within the prescribed targets 89% of the time. Ninety-six subjects experienced clinical deterioration as defined by the need to be transferred to the ICU and\/or requirement of high flow nasal oxygen but none of these events were judged to be related to the O\n                      <jats:sub>2<\/jats:sub>\n                      device.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      Automated O\n                      <jats:sub>2<\/jats:sub>\n                      titration could be successfully implemented in hospitalized subjects with hypoxemic respiratory failure from various causes. This experience should foster further improvement of the device and recommendations for an optimized utilization.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.11331","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T13:55:12Z","timestamp":1710510912000},"page":"1081-1091","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Implementation of Automated Oxygen Titration in a Tertiary Care Hospital"],"prefix":"10.1177","volume":"69","author":[{"given":"Pierre-Alexandre","family":"Bouchard","sequence":"first","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevi\u00e8ve","family":"Parent-Racine","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassiop\u00e9e","family":"Paradis-Gagnon","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Simon","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Lacasse","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lellouche","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Maltais","sequence":"additional","affiliation":[{"name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec, Universit\u00e9 Laval, Qu\u00e9bec, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1302298"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c5462"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)30479-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209729"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4169"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12620"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000520294"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09294"},{"key":"e_1_3_3_10_2","first-page":"1067","article-title":"Acute oxygen therapy: a review of prescribing and delivery practices","volume":"11","author":"Cousins JL","year":"2016","unstructured":"Cousins JL, , Wark PAB, , McDonald VM. 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