{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:17:27Z","timestamp":1783567047193,"version":"3.55.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Patients with obesity are at increased risk of postoperative pulmonary complications. CPAP has been used successfully to prevent and treat acute respiratory failure, but in many clinical scenarios, high-flow nasal cannula (HFNC) therapy is emerging as a possible alternative. We aimed to compare HFNC and CPAP in a sequential study measuring their effects on gas exchange, lung volumes, and gas distribution within the lungs measured through electrical impedance tomography (EIT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      We enrolled 15 subjects undergoing laparoscopic bariatric surgery. Postoperatively they underwent the following oxygen therapy protocol (10 min\/step): baseline air-entrainment mask, HFNC at increasing (40, 60, 80, and 100 L\/min) and decreasing flows (80, 60, and 40 L\/min), washout air-entrainment mask and CPAP (10 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O). Primary outcome was the change in end-expiratory lung impedance (\u0394EELI) measured by EIT data processing. Secondary outcomes were changes of global inhomogeneity (GI) index and tidal impedance variation (TIV) measured by EIT, arterial oxygenation, carbon dioxide content, pH, respiratory frequency, and subject\u2019s comfort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Thirteen subjects completed the study. Compared to baseline, \u0394EELI was higher during 10 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O CPAP (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .001) and HFNC 100 L\/min (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02), as well as during decreasing flows HFNC 80, 60, and 40 L\/min (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .008, .004, and .02, respectively). GI index was lower during HFNC 100 compared to HFNC 60\n                      <jats:sub>increasing<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .044), HFNC 60\n                      <jats:sub>decreasing<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .02) HFNC 40\n                      <jats:sub>decreasing<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01), and during 10 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O CPAP compared to washout period (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01) and HFNC 40\n                      <jats:sub>decreasing<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03). TIV was higher during 10 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O CPAP compared to baseline (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .008). Compared to baseline, breathing frequency was lower at HFNC 60\n                      <jats:sub>increasing<\/jats:sub>\n                      , HFNC 100, and HFNC 80\n                      <jats:sub>decreasing<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .01, .02, and .03, respectively). No differences were detected regarding arterial oxygenation, carbon dioxide content, pH, and subject\u2019s comfort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      HFNC at a flow of 100 L\/min induced postoperative pulmonary recruitment in bariatric subjects, with no significant differences compared to 10 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O CPAP in terms of lung recruitment and ventilation distribution.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.11356","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T10:25:14Z","timestamp":1715682314000},"page":"990-998","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Lung Volume and Ventilation Distribution After Bariatric Surgery: High-Flow Nasal Cannula Versus CPAP"],"prefix":"10.1177","volume":"69","author":[{"given":"Enrico","family":"Lena","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Cattinara Hospital, ASUGI, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Comuzzi","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Cattinara Hospital, ASUGI, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Aj\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Department of Engineering and Architecture, University of Trieste, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Tarchini","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Cattinara Hospital, ASUGI, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Moro","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Cattinara Hospital, ASUGI, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Baso","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Cattinara Hospital, ASUGI, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Dal Zilio","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Cattinara Hospital, ASUGI, Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy; 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