{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T05:53:18Z","timestamp":1780638798117,"version":"3.54.1"},"reference-count":20,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Adaptive pressure control\u2013continuous mandatory ventilation (APC-CMV) is a frequently utilized ventilator mode in ICU settings. This analysis compared APC-CMV and traditional volume control\u2013continuous mandatory ventilation (VC-CMV) mode, describing factors associated with initiation, maintenance, and changes in settings of each mode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We analyzed ventilator data from a retrospective electronic health record data set collected as part of a quality improvement project in a single academic ICU. The majority ventilator mode was defined as the mode comprising the highest proportion of mechanical ventilation time. Multivariable logistic regression was used to identify variables associated with initial and majority APC-CMV or VC-CMV modes. Wilcoxon rank-sum tests were used to compare ventilator setting changes\/d and sedation as a function of APC-CMV and VC-CMV majority modes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Among 1,213 subjects initiated on mechanical ventilation from January 2013\u2013March 2017, 68% and 24% were initiated on APC-CMV and VC-CMV, respectively, which composed 62% and 21% of the majority ventilator modes. Age, sex, race, and ethnicity were not associated with the initial or majority APC-CMV or VC-CMV modes. Subjects initiated on APC-CMV spent 88% of the mechanical ventilation time on APC-CMV mode. Compared to VC-CMV, subjects with APC-CMV majority mode experienced more ventilator setting changes\/d (1.1 vs 0.8,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). There were no significant differences in sedative medications when comparing subjects receiving APC-CMV versus VC-CMV majority modes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>APC-CMV was highly utilized in the medical ICU. Subjects on APC-CMV had more ventilator setting changes\/d than those on VC-CMV. APC-CMV offered no advantage of reduced setting adjustments or less sedation compared to VC-CMV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.11430","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T13:55:19Z","timestamp":1722952519000},"page":"1491-1498","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Adaptive Pressure Control\u2013Continuous Mandatory Ventilation Versus Volume Control\u2013Continuous Mandatory Ventilation: Factors Associated With Initiation, Maintenance, and Adjustment"],"prefix":"10.1177","volume":"69","author":[{"given":"Linh N","family":"Tran","sequence":"first","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, School of Medicine, La Jolla, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared E","family":"Rosen","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of California, Davis, School of Medicine, Sacramento, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex K","family":"Pearce","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, School of Medicine, La Jolla, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, School of Medicine, La Jolla, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell G","family":"Buhr","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; and Center for the Study of Healthcare Innovation, Implementation, and Policy, Health Services Research and Development, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragan","family":"Saggar","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A","family":"Davis","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L","family":"Martin","sequence":"additional","affiliation":[{"name":"VA Greater Los Angeles Healthcare System, Geriatric Research, Education and Clinical Center, Los Angeles, California; and Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biren B","family":"Kamdar","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care and Sleep Medicine, University of California, San Diego, School of Medicine, La Jolla, California; and VA San Diego Healthcare System, La Jolla, California."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200106283442606"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04490742"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.5.9902018"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.4.1225"},{"issue":"1","key":"e_1_3_2_6_2","article-title":"Long-term volume-targeted pressure controlled ventilation: sense or nonsense?","volume":"50","author":"Arellano-Maric MP","year":"2017","unstructured":"Arellano-Maric MP, , Gregoretti C, , Duiverman M, , Windisch W. Long-term volume-targeted pressure controlled ventilation: sense or nonsense?. Eur Respir J, 2017; 50(1).","journal-title":"Eur Respir J"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.07520478"},{"key":"e_1_3_2_8_2","first-page":"100822","article-title":"Pressure-regulated volume control (PRVC): set it and forget it?","volume":"29","author":"Singh G","year":"2020","unstructured":"Singh G, , Chien C, , Patel S. Pressure-regulated volume control (PRVC): set it and forget it?. Respir Med Case Rep, 2020; 29:100822.","journal-title":"Respir Med Case Rep"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1751143719878969"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S99156"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc107"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.202203-200RL"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09541467"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08530897"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1424OC"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066613519574"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05500202"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181f00015"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003801"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202206-1208OC"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03710-6"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.11430","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.11430","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.11430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:58:10Z","timestamp":1775465890000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.11430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.4187\/respcare.11430"],"URL":"https:\/\/doi.org\/10.4187\/respcare.11430","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,18]]}}}