{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T06:05:58Z","timestamp":1775541958773,"version":"3.50.1"},"reference-count":23,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T00:00:00Z","timestamp":1721779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>\n                      In 2013, a new predictor of successful mechanical ventilation liberation named timed inspiratory effort (TIE) index was devised with the normalization of the maximum inspiratory pressure (obtained within 60 s of unidirectional airway occlusion) with the time at which the value was reached. The aim of this study was to verify whether the presence of a sequence of a certain number of inspiratory effort values between 30\u201360 s &gt; 1.0 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/s could predict weaning success in a performance comparable to the TIE index.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      This was a retrospective observational study using 4 databases of previous studies on the TIE index. All patients receiving mechanical ventilation for \u2264 24 h were eligible. Liberation from mechanical ventilation-extubation decisions was made based on performance with spontaneous breathing trials.\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .05 was considered significant. The performance of the TIE index was evaluated by calculating the area under the receiver operating characteristics (AUROC) curve.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      From 349 eligible patients, 165 subjects were selected for analysis. The AUROC for the TIE index in the studied sample was 0.92 (95% CI 0.87\u20130.97,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). A sequence of \u2264 4 inspiratory efforts &gt; 1.0 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/s was found in 51.5% of the subjects, with successful ventilatory liberation occurring in 95.3%. The highest specificity values belonged to the sequence of \u2264 4 and \u2264 5 inspiratory efforts &gt; 1.0 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/s; the highest positive predictive value and positive likelihood ratio belonged to the sequence of \u2264 4 inspiratory efforts &gt; 1.0 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/s. The mean time that could have been spared if the procedure were interrupted after the first sequence of 4 inspiratory efforts &gt; 1.0 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/s was 23 \u00b1 3 s.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      The presence of a sequence of \u2264 4 inspiratory efforts &gt; 1.0 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/s during the TIE index measurement was a reliable predictor of weaning success, which could allow timely interruption of the procedure and entail a substantial reduction in airway occlusion time\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.11546","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T14:05:12Z","timestamp":1712066712000},"page":"953-958","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Reducing Airway Occlusion Time Without Losing Accuracy to Predict Successful Mechanical Ventilator Liberation During the Measurement of the Timed Inspiratory Effort Index"],"prefix":"10.1177","volume":"69","author":[{"given":"Raphaela Cristinne Carvalho","family":"Cordeiro","sequence":"first","affiliation":[{"name":"Medical Science Post-Graduation Program, Universidade Federal Fluminense, Niter\u00f3i, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Cordeiro","family":"de Souza","sequence":"additional","affiliation":[{"name":"Physiotherapy College, Est\u00e1cio de S\u00e1 University, Niter\u00f3i, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocemir Ronaldo","family":"Lugon","sequence":"additional","affiliation":[{"name":"Medicine\/Nephrology, Medical School of Universidade Federal Fluminense, Niter\u00f3i, Rio de Janeiro, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00010206"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132007000800008"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.159"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201602-0320OC"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209041"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.63.6.1002"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0883-9441(86)80114-9"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/142.3.529"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105233242101"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.4_Pt_1.860"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.4.1096"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc8051"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.01489"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/0885066613483265"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03393"},{"key":"e_1_3_3_17_2","first-page":"902541","article-title":"Mechanical ventilation weaning in inclusion body myositis: feasibility of isokinetic inspiratory muscle training as an adjunct therapy","volume":"2014","author":"Cordeiro de Souza L","year":"2014","unstructured":"Cordeiro de Souza L, , Campos JF, , Daher LP, , Furtado da Silva P, , Ventura A, , do Prado PZ, et al. Mechanical ventilation weaning in inclusion body myositis: feasibility of isokinetic inspiratory muscle training as an adjunct therapy. Case Rep Crit Care, 2014; 2014:902541.","journal-title":"Case Rep Crit Care"},{"key":"e_1_3_3_18_2","first-page":"1","article-title":"Inspiratory muscle training with isokinetic device to help ventilatory weaning in a patient with Guillain-Barr\u00e9 syndrome by Zika virus","volume":"2018","author":"Souza LC","year":"2018","unstructured":"Souza LC, , Abreu A, , Pinto EE, , Ribeiro LH, , Godoy MDP, , Junior WAS, et al. Inspiratory muscle training with isokinetic device to help ventilatory weaning in a patient with Guillain-Barr\u00e9 syndrome by Zika virus. 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