{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T09:58:14Z","timestamp":1775469494493,"version":"3.50.1"},"reference-count":57,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUD:<\/jats:title>\n                    <jats:p>\n                      Lung volume measurements are important for monitoring functional aeration and recruitment and may help guide adjustments in ventilator settings. The expiratory phase of airway pressure release ventilation (APRV) may provide physiologic information about lung volume based on the expiratory flow-time slope, angle, and time to approach a no-flow state (expiratory time [T\n                      <jats:sub>E<\/jats:sub>\n                      ]). We hypothesized that expiratory flow would correlate with estimated lung volume (ELV) as measured using a modified nitrogen washout\/washin technique in a large-animal lung injury model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>\n                      Eight pigs (35.2 \u00b1 1.0 kg) were mechanically ventilated using an Engstr\u00f6m Carescape R860 on the APRV mode. All settings were held constant except the expiratory duration, which was adjusted based on the expiratory flow curve. Abdominal pressure was increased to 15 mm Hg in normal and injured lungs to replicate a combination of pulmonary and extrapulmonary lung injury. ELV was estimated using the Carescape FRC INview tool. The expiratory flow-time slope and T\n                      <jats:sub>E<\/jats:sub>\n                      were measured from the expiratory flow profile.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Lung elastance increased with induced lung injury from 29.3 \u00b1 7.3 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/L to 39.9 \u00b1 15.1cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/L, and chest wall elastance increased with increasing intra-abdominal pressures (IAPs) from 15.3 \u00b1 4.1 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/L to 25.7 \u00b1 10.0 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/L in the normal lung and 15.8 \u00b1 6.0 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/L to 33.0 \u00b1 6.2 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O\/L in the injured lung (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .39). ELV decreased from 1.90 \u00b1 0.83 L in the injured lung to 0.67 \u00b1 0.10 L by increasing IAP to 15 mm Hg. This had a significant correlation with a T\n                      <jats:sub>E<\/jats:sub>\n                      decrease from 2.3 \u00b1 0.8 s to 1.0 \u00b1 0.1 s in the injured group with increasing insufflation pressures (\u03c1 = 0.95) and with the expiratory flow-time slope, which increased from 0.29 \u00b1 0.06 L\/s\n                      <jats:sup>2<\/jats:sup>\n                      to 0.63 \u00b1 0.05 L\/s\n                      <jats:sup>2<\/jats:sup>\n                      (\u03c1 = 0.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>\n                      Changes in ELV over time, and the T\n                      <jats:sub>E<\/jats:sub>\n                      and flow-time slope, could be used to demonstrate evolving lung injury during APRV. Using the slope to infer changes in functional lung volume represents a unique, reproducible, real-time, bedside technique that does not interrupt ventilation and may be used for clinical interpretation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.11745","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T08:40:15Z","timestamp":1708936815000},"page":"1432-1443","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation"],"prefix":"10.1177","volume":"69","author":[{"given":"Harry","family":"Ramcharran","sequence":"first","affiliation":[{"name":"Department of Surgery, SUNY Upstate Medical University, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Wetmore","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Cincinnati, Cincinnati, Ohio."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Morehouse School of Medicine, Atlanta, Georgia."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Herrmann","sequence":"additional","affiliation":[{"name":"Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Fonseca da Cruz","sequence":"additional","affiliation":[{"name":"Department of Anesthesia, University of Iowa, Iowa City, Iowa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W","family":"Kaczka","sequence":"additional","affiliation":[{"name":"Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa City, Iowa; Department of Anesthesia, University of Iowa, Iowa City, Iowa; and Department of Radiology, University of Iowa, Iowa City, Iowa."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua","family":"Satalin","sequence":"additional","affiliation":[{"name":"Department of Surgery, SUNY Upstate Medical University, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Blair","sequence":"additional","affiliation":[{"name":"Department of Surgery, SUNY Upstate Medical University, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penny L","family":"Andrews","sequence":"additional","affiliation":[{"name":"Department of Trauma Critical Care Medicine, R Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nader M","family":"Habashi","sequence":"additional","affiliation":[{"name":"Department of Trauma Critical Care Medicine, R Adams Cowley Shock Trauma Center, University of Maryland Medical Center, Baltimore, Maryland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary F","family":"Nieman","sequence":"additional","affiliation":[{"name":"Department of Surgery, SUNY Upstate Medical University, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Kollisch-Singule","sequence":"additional","affiliation":[{"name":"Department of Surgery, SUNY Upstate Medical University, Syracuse, New York."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.5.9802003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000096261.89531.90"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1946.146.2.161"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc7125"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201008-1318OC"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2403-1"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-6576.2002.460615.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200710-1589OC"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.6.2005001"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.128.5.3757"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc7139"},{"issue":"3","key":"e_1_3_2_13_2","first-page":"347","article-title":"Functional residual capacity and absolute lung volume","volume":"20","author":"Gommers D","year":"2014","unstructured":"Gommers D. Functional residual capacity and absolute lung volume. Curr Opin Crit Care, 2014; 20(3):347-351.","journal-title":"Curr Opin Crit Care"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00069712"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-006-9029-9"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13552"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020777912363"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107042"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-003-1730-2"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.6.correspondence"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2011.02511.x"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-009-1512-6"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/46.7.479"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01724875"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198205000-00010"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000165823.90368.55"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-021-02703-x"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000155920.11893.37"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1208707"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2013-0453TR"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-017-0138-1"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc11146"},{"key":"e_1_3_2_33_2","volume-title":"Physiology, functional residual capacity","author":"Hopkins E","year":"2022","unstructured":"Hopkins E, , Sharma S. Physiology, functional residual capacity. Treasure Island (Florida): StatPearls; 2022."},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01724872"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1159\/000198252"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.4103\/0972-9941.72593"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-8180(97)00251-1"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00552.2014"},{"issue":"3","key":"e_1_3_2_39_2","first-page":"756","article-title":"Action of the diaphragm on the rib cage inferred from a force-balance analysis","volume":"53","author":"Loring SH","year":"1982","unstructured":"Loring SH, , Mead J. Action of the diaphragm on the rib cage inferred from a force-balance analysis. J Appl Physiol Respir Environ Exerc Physiol, 1982; 53(3):756-760.","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/0952-8180(96)00017-7"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2169-9"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.158.1.9708031"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31827417a6"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2333-y"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc6961"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-021-00800-2"},{"key":"e_1_3_2_47_2","article-title":"Minimizing lung injury during laparoscopy in head-down tilt: a physiological cohort study","author":"De Meyer GRA","year":"2022","unstructured":"De Meyer GRA, , Morrison SG, , Saldien V, , Jorens P, , Schepens T. Minimizing lung injury during laparoscopy in head-down tilt: a physiological cohort study. Cardiovasc Pathophys Outcomes, 2022.","journal-title":"Cardiovasc Pathophys Outcomes"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03700-8"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2016.2572678"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2014.1829"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e31825c7a82"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31827b47bb"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-010-0237-6"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0554-3"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201404-151CC"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.06.64"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc10587"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-925X-12-57"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.11745","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.11745","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.11745","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:58:13Z","timestamp":1775465893000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.11745"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":57,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.4187\/respcare.11745"],"URL":"https:\/\/doi.org\/10.4187\/respcare.11745","relation":{},"ISSN":["0020-1324"],"issn-type":[{"value":"0020-1324","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10,25]]}}}