{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:40:43Z","timestamp":1790026843550,"version":"4.0.1"},"reference-count":48,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respir Care"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>This Population, Intervention, Comparison, and Outcomes\u2013guided systematic review assesses continuous lateral rotation therapy versus conventional position changes in mechanically ventilated critically ill adults, evaluating mortality, ICU length of stay (LOS), and hospital LOS as primary outcomes and respiratory function, mechanical ventilation duration, pulmonary complications, and adverse events as secondary outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This systematic review follows Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria (International Prospective Register of Systematic Reviews CRD42022384258). Searches spanned databases MEDLINE\/PubMed, Embase, Scopus, ScienceDirect, Cochrane, CINAHL, and Web of Science, without language or publication year restrictions. Inclusion criteria involved randomized controlled trials (RCTs) and quasi\u2013randomized trials, comparing continuous lateral rotation therapy (intervention) with conventional position changes (control). Risk of bias and quality of evidence for RCTs were assessed using the Cochrane Collaboration and Grading of Recommendations Assessment, Development, and Evaluation tools. For the quasi\u2013randomized trials, the Risk of Bias in Non-Randomized Studies-of Interventions tool was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      In 18 studies with 1,466 participants (intervention,\n                      <jats:italic toggle=\"yes\">n =<\/jats:italic>\n                      700, 47.7%; control,\n                      <jats:italic toggle=\"yes\">n =<\/jats:italic>\n                      766, 52.2%), continuous lateral rotation therapy was predominantly used for prophylactic purposes, with protocols varying from 10\u201324 h\/d. Meta-analysis (16 RCTs) favored continuous lateral rotation therapy for reduced mechanical ventilation duration (standardized mean difference [SMD] \u22120.17 [CI \u22120.29 to \u22120.04] d,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .008) and lower nosocomial pneumonia incidence (odds ratio 0.39 [CI 0.29\u20130.52],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .001). Continuous lateral rotation therapy showed no significant impact on mortality (odds ratio 1.04 [CI 0.80\u20131.34],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .77), ICU LOS (SMD \u22120.11 [CI \u22120.25 to 0.02] d,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .11), hospital LOS (SMD \u22120.10 [CI \u22120.31 to 0.11] d,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .33), and incidence of pressure ulcers (odds ratio 0.73 [CI 0.34\u20131.60],\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .44).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Continuous lateral rotation therapy showed no significant difference in primary outcomes (mortality, ICU and hospital LOS) but revealed significant differences in secondary outcomes (consistently reduced nosocomial pneumonia, with a minor effect on mechanical ventilation duration), supported by moderate certainty. Very low certainty for other outcomes highlights the need for current studies in diverse clinical settings and protocols to assess continuous lateral rotation therapy effectiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.11781","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T13:15:10Z","timestamp":1715692510000},"page":"1592-1606","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Continuous Lateral Rotation Therapy on Clinical Outcomes in Mechanically Ventilated Critically Ill Adults"],"prefix":"10.1177","volume":"69","author":[{"given":"Anna Lu\u00edsa A","family":"Brito","sequence":"first","affiliation":[{"name":"Rehabilitation Sciences Program at the Federal University of Pernambuco, Recife, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Caroline A","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Rehabilitation Sciences Program at the Federal University of Pernambuco, Recife, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layane Santana P","family":"Costa","sequence":"additional","affiliation":[{"name":"Rehabilitation Sciences Program at the Federal University of Pernambuco, Recife, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuel Fernandes F","family":"Silva J\u00fanior","sequence":"additional","affiliation":[{"name":"Health-Applied Biology Graduate Program at the Federal University of Pernambuco, Recife, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley Lima","family":"Campos","sequence":"additional","affiliation":[{"name":"Rehabilitation Sciences Program and the Health-Applied Biology Graduate Program at the Federal University of Pernambuco, Recife, Pernambuco, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5567.731"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-015-0071-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PTS.0000000000000582"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2015171"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-5153.2011.00458.x"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2011.08.034"},{"issue":"4","key":"e_1_3_2_8_2","first-page":"53S","article-title":"The effect of continuous lateral rotation vs conventional critical care bed in the management of acute respiratory distress syndrome. 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