{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:28:50Z","timestamp":1785439730816,"version":"3.56.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Exercise-induced bronchoconstriction (EIB) is common in children with asthma, but whether it is a phenomenon of central versus peripheral airway reactivity is unknown. The purpose of this study was to investigate central and peripheral airway responses after an exercise challenge test among children with asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Sixteen children with asthma underwent exercise challenge testing on 2 separate visits: one without any medications (control) and another with pretreatment with 180 \u00b5g albuterol (bronchodilator). Central airway EIB was defined as a &gt;10% reduction in FEV\n                      <jats:sub>1<\/jats:sub>\n                      after exercise assessed with spirometry. Peripheral airway EIB was assessed as a &gt;40% increase in resistance between 5 Hz and 20 Hz with impulse oscillometry. Spirometry and impulse oscillometry were measured before the condition and periodically for up to 30 min after exercise.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Three of 16 children (19%) experienced only central airway EIB. Ten of 16 children (62%), including all 3 who experienced central airway EIB, experienced peripheral airway EIB. Among children who experienced EIB, resistance between 5 Hz and 20 Hz increased by 119.67 \u00b1 102.56% after exercise during the control condition compared with an average decrease of \u201310.38 \u00b1 34.97% during the bronchodilator condition, which suggests that albuterol was effective in preventing EIB (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.003, paired\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      test).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Peripheral airway EIB may occur frequently in children with asthma. Spirometry-based testing alone may miss peripheral airway EIB in some children. Impulse oscillometry could be used in conjunction with spirometry to detect peripheral airway EIB in children with asthma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.11929","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T10:37:23Z","timestamp":1773311843000},"page":"400-407","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Detecting Peripheral Airway Response in Exercise-Induced Bronchoconstriction: The Role of Impulse Oscillometry"],"prefix":"10.1177","volume":"70","author":[{"given":"Kali","family":"McKnight","sequence":"first","affiliation":[{"name":"Ms. McKnight is affiliated with the Medical Student Research Program, The Ohio State University College of Medicine, The Ohio State University, Columbus, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Dr. Wong is affiliated with the Department of Kinesiology and Nutrition Sciences, University of Nevada Las Vegas, Las Vegas, Nevada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lung-Chang","family":"Chien","sequence":"additional","affiliation":[{"name":"Dr. Chien is affiliated with the Department of Epidemiology and Biostatistics, School of Public Health, University of Nevada Las Vegas, Las Vegas, Nevada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Dr. Nakamura is affiliated with Childrens Lung Specialists, Las Vegas, Nevada."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason E.","family":"Lang","sequence":"additional","affiliation":[{"name":"Dr. Lang is affiliated with the Division of Pulmonary and Sleep Medicine, Duke Children\u2019s Hospital and Health Center, Durham, North Carolina."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony G.","family":"Babb","sequence":"additional","affiliation":[{"name":"Dr. Babb is affiliated with the Institute for Exercise and Environmental Medicine, UT Southwestern Medical Center, Texas Health Presbyterian Hospital, Dallas, Texas."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dharini M.","family":"Bhammar","sequence":"additional","affiliation":[{"name":"Dr. Bhammar is affiliated with the Center for Tobacco Research, Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7005a1"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.8306029"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2013.02.006"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0437ST"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000728"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2018.08.023"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.020514"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.44.235.291"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23758"},{"issue":"1","key":"e_1_3_4_11_2","first-page":"309","article-title":"Guidelines for methacholine and exercise challenge testing-1999. 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