{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:27:05Z","timestamp":1784672825184,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Respiratory Care"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Mechanical insufflation-exsufflation (MI-E) is crucial to assist patients with impaired cough, especially those with neuromuscular diseases. Despite recent advancements that enable real-time display of peak expiratory flow (PEF) and inspiratory volume, accurately monitoring these parameters with MI-E devices during treatment can still present challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A bench study that used a mechanical lung connected to 3 MI-E devices (EOVE-70; E-70 and Comfort Cough II) was conducted to evaluate PEF and inspiratory volume monitoring accuracy. Two clinical conditions were tested, low and normal compliance, with 6 different MI-E settings tested: +20\/\u201320, +30\/\u201330, +40\/\u201340, +40\/\u201350, +40\/\u201360, and +40\/\u201370 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O. PEF (L\/min) and inspiratory volume (mL) displayed on the screen were recorded cycle by cycle, while a pneumotachograph connected to the mechanical lung was used to measure the actual PEF and inspiratory volume for data comparison. Flow bias was assessed by calculating the difference (PEF \u2013 peak inspiratory flow) and ratio (PEF to peak inspiratory flow) between flows.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      All devices systematically underestimated PEF, with device A showing the smallest estimation error (\u20137.4 [\u201310.1; \u20136] %). Devices B and C exhibited larger errors (\u201326.5 [\u201329.2; \u201325.6] and (\u201329.9 [\u201330.7; \u201328.7] %, respectively). All the devices underestimated inspiratory volume, with device B showing the smallest estimation error (\u201315.1 [\u201321.2; \u201312.3] %). Device A exhibited a significantly larger error (\u201326.9 [\u201330.3; \u201324.8] %). The error from device C (\u201317.7 [\u201334.5; \u201313.8] %) was not statistically different from device B. Device type, high pressure settings (&gt;+40\/\u201340 cm H\n                      <jats:sub>2<\/jats:sub>\n                      O), and a lung model compliance of 60 mL\/cm H\n                      <jats:sub>2<\/jats:sub>\n                      O were the main contributors to error in estimating PEF and inspiratory volume. Finally, we observed differences of PEF\u2013to\u2013peak inspiratory flow ratio and PEF minus peak inspiratory flow differences achieved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study highlighted consistent underestimation of PEF and inspiratory volume across MI-E devices. Improving device monitoring is essential for guiding MI-E therapy and ensuring patient safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4187\/respcare.12221","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T14:45:21Z","timestamp":1730213121000},"page":"313-318","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Accuracy of Real-Time Data Provided by Mechanical Insufflation-Exsufflation Devices"],"prefix":"10.1177","volume":"70","author":[{"given":"Roberto","family":"Mart\u00ednez-Alejos","sequence":"first","affiliation":[{"name":"Drs. Mart\u00ednez-Alejos, Fresnel, and Lebret are affiliated with the Kernel Biomedical. Rouen, France."},{"name":"Dr. Martinez-Alejos is affiliated with the Montpellier University Training School of Physiotherapy. Montpellier, France."},{"name":"Dr. Mart\u00ednez-Alejos is affiliated with the Deusto University, San Sebastian, Spain."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Fresnel","sequence":"additional","affiliation":[{"name":"Drs. Mart\u00ednez-Alejos, Fresnel, and Lebret are affiliated with the Kernel Biomedical. Rouen, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Vuillermoz","sequence":"additional","affiliation":[{"name":"Drs. Vuillermoz, Beloncle, and Lebret are affiliated with the Angers University Hospital, Vent\u2019Lab, Angers, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Beloncle","sequence":"additional","affiliation":[{"name":"Drs. Vuillermoz, Beloncle, and Lebret are affiliated with the Angers University Hospital, Vent\u2019Lab, Angers, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Lebret","sequence":"additional","affiliation":[{"name":"Drs. Mart\u00ednez-Alejos, Fresnel, and Lebret are affiliated with the Kernel Biomedical. Rouen, France."},{"name":"Dr. Lebret is affiliated with the Med2Lab, ALMS, Antony, France."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5874.282"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201406-264OC"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.01.012"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09704"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.10173"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05965"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1987.62.3.959"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13092643"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.07.007"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.03809"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.10086"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1140\/epjnbp\/s40366-014-0007-8"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12072626"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06882"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2018.10.012"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.154.4.8887585"},{"key":"e_1_3_4_18_2","first-page":"101649","article-title":"From bedside to bench - in vivo and in vitro evaluation of mechanically assisted cough treatment in a patient with bulbar amyotrophic lateral sclerosis","volume":"37","author":"Andersen T","year":"2022","unstructured":"Andersen T, , Fondenes O, , R\u00f8ksund OD, , Clemm H, , Halvorsen T, , Volls\u00e6ter M. From bedside to bench - in vivo and in vitro evaluation of mechanically assisted cough treatment in a patient with bulbar amyotrophic lateral sclerosis. Respir Med Case Rep. 2022; 37:101649.","journal-title":"Respir Med Case Rep"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2019.06.012"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.09978"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.3.658"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.08531287"}],"container-title":["Respiratory Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.4187\/respcare.12221","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.12221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.4187\/respcare.12221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:19:55Z","timestamp":1777616395000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.4187\/respcare.12221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.4187\/respcare.12221"],"URL":"https:\/\/doi.org\/10.4187\/respcare.12221","relation":{},"ISSN":["1943-3654","1943-3654"],"issn-type":[{"value":"1943-3654","type":"print"},{"value":"1943-3654","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]}}}