{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T23:16:19Z","timestamp":1770592579795,"version":"3.49.0"},"reference-count":0,"publisher":"Stichting Nase","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rhin"],"published-print":{"date-parts":[[2009,12,1]]},"abstract":"<jats:p>Objective: To image olfactory nerve regeneration in vivo using a high-resolution gamma cam- era and radiography after nasal administration of thallium-201 (olfacto-scintigraphy).  Methods: Six Wistar rats were trained to avoid the smell of cycloheximide as a test of olfactory function. The olfactory nerve fibers of 3 rats were then carefully transected bilaterally with a Teflon knife, avoiding damage to the olfactory bulbs. The remaining 3 rats underwent sham operations and were used as controls. Steel wires were implanted in the left olfactory bulb of each rat for locating the bulbs with plain X-rays. The rats were assessed 2, 14, 28, and 42 d after the olfactory nerve transection or sham operation for their ability to detect odours and for transport of 201Tl to the olfactory bulb area 8 h after nasal administration of 201Tl.  Results: Both transport of 201Tl to the olfactory bulb area (p &lt; 0.04) and ability to detect odours (p &lt; 0.04) significantly increased with a time course after olfactory nerve transection.  Conclusion: 201Tl transport to the olfactory bulb may be useful to visually assess olfactory ability in vivo. We plan to test olfacto-scintigraphy clinically by nasal administration of 201Tl in patients with posttraumatic olfactory loss.<\/jats:p>","DOI":"10.4193\/rhin08.213","type":"journal-article","created":{"date-parts":[[2015,7,28]],"date-time":"2015-07-28T09:46:44Z","timestamp":1438076804000},"page":"460-464","source":"Crossref","is-referenced-by-count":9,"title":["Use of thallium transport to visualize functional olfactory nerve regeneration in vivo"],"prefix":"10.4193","volume":"47","author":[{"given":"H.","family":"Shiga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Washiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Amano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Furukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Miwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2708","container-title":["Rhinology journal"],"original-title":[],"deposited":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T14:12:08Z","timestamp":1645107128000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.rhinologyjournal.com\/Abstract.php?id=811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,12,1]]}},"URL":"https:\/\/doi.org\/10.4193\/rhin08.213","relation":{},"ISSN":["0300-0729"],"issn-type":[{"value":"0300-0729","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12,1]]}}}