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Secondary outcomes were the overall survival (OS), and the distant-metastases free survival (DMFS), that were reported as logarithm of the hazard ratios (logHRs) and 95% confidence intervals (CIs). Results: A total of 489 clinically node negative patients were included from 9 retrospective studies. ENI significantly reduced the risk of regional recurrence compared to no treatment. No difference was measured between ENI and observation, according to both OS and DMFS. No stratified analysis could be performed based on Kadish stage and Hyams grade. Conclusions: ENI should be recommended to improve the regional disease control. No advantage was measured in terms of survival or distant metastases with a low quality of evidence. Further prospective studies should be designed to understand if ENI could be avoided in early stage and low-grade tumors.<\/jats:p>","DOI":"10.4193\/rhin21.139","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T07:15:14Z","timestamp":1626160514000},"page":"0-0","source":"Crossref","is-referenced-by-count":3,"title":["Elective neck irradiation in the management of  esthesioneuroblastoma: a systematic review and meta-analysis"],"prefix":"10.4193","volume":"0","author":[{"given":"A.","family":"De Virgilio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Costantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sebastiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Franzese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mercante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Scorsetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Spriano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2708","published-online":{"date-parts":[[2021,7,1]]},"reference":[{"issue":"3","key":"ref0","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1001\/archotol.133.3.276","article-title":"Esthesioneuroblastoma: a population-based analysis of survival and prognostic factors","volume":"133","author":"Jethanamest","year":"2007","unstructured":"1. 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