{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T14:02:54Z","timestamp":1776520974823,"version":"3.51.2"},"reference-count":0,"publisher":"Stichting Nase","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rhin"],"abstract":"<jats:p>Background: Rhinosinusitis-induced brain abscesses are rare but can result in devastating long-term sequalae and mortality; they require a high index of suspicion with early imaging to start early empiric parenteral antibiotic treatment covering aerobes and anaerobes. Methodology: Our study was a retrospective analysis on 32 patients who were treated at Oxford University Hospitals for rhinosinusitis-induced brain abscess between February 2013 and June 2020. Results: Mean age of presentation was 45.83 for adults and 11.14 for children. Subdural collection was the most frequent abscess but 25% of patients had multiple sites of collection; the majority were in the frontal lobe. The most commonly identified pathogens were Streptococcus milleri group and Staphylococcus aureus; 93.75% of the patients were treated with combined Ceftriaxone and Metronidazole for an average of 8 weeks. Conclusions: In our series most patients received also a prompt and aggressive surgical treatment with combined neurosurgical and ENT procedures in the majority; this was especially important in case of subdural empyema, Streptococcus milleri infection and direct intracranial spread of infection. More than half of the patients were treated with a single surgical procedure. Despite aggressive treatment, one third of patients experienced long-term neurological sequelae; there were no deaths.<\/jats:p>","DOI":"10.4193\/rhin22.070","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T11:49:16Z","timestamp":1655812156000},"page":"0-0","source":"Crossref","is-referenced-by-count":2,"title":["A surgical protocol for sinogenic brain abscess: the Oxford experience and a review of the literature"],"prefix":"10.4193","volume":"0","author":[{"given":"F.","family":"Bandino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Thota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L.","family":"Pendolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chaidas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Jeyaretna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Martinez-Devesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Qureishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2708","published-online":{"date-parts":[[2022,6,21]]},"container-title":["Rhinology journal"],"original-title":[],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T11:49:16Z","timestamp":1655812156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.rhinologyjournal.com\/Abstract.php?id=3008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,21]]},"references-count":0,"journal-issue":{"issue":"0","published-online":{"date-parts":[[2022,6,21]]}},"URL":"https:\/\/doi.org\/10.4193\/rhin22.070","relation":{},"ISSN":["0300-0729"],"issn-type":[{"value":"0300-0729","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6,21]]}}}