{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T07:51:51Z","timestamp":1782287511442,"version":"3.54.5"},"reference-count":0,"publisher":"Stichting Nase","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rhin"],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>BACKGROUND: Nasal polyposis (NP) is associated with a more severe and steroid-resistant asthma. OBJECTIVE: To compare clinical and airway inflammatory features of asthmatics with or without NP. METHODS: Two groups of asthmatic patients were studied: group 1; n=39, with NP; group 2; n=40, without NP. Asthma control was assessed according to the Asthma Control Scoring System (ACSS). Expiratory flows, induced sputum, and blood eosinophils were also measured. RESULTS: ACSS score was lower (poorer control) in group 1 (meanA+-SEM = 73A+-3%) compared with group 2 (82A+-2%, p=0.01). FEV1 (mean of predicted value A+- SEM) was 81A+-3 for group 1 and 96A+-3 for group 2 (p=0.001), and the FEV1\/FVC ratio was lower in group 1 (70A+-2%) compared with group 2 (76A+-1%, p=0.01). Blood and induced sputum eosinophils, as well as fibronectin and eosinophil cationic protein levels, were higher in group 1. CONCLUSION: Asthmatic subjects with NP have increased airway obstruction, increased inflammatory cells and reduced asthma control compared to those without NP. This may suggest a contribution of nasal polyps to the severity of asthma or a common susceptibility to develop upper and lower airways mucosal inflammation.<\/jats:p>","DOI":"10.4193\/rhino09.095","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T10:55:42Z","timestamp":1621508142000},"page":"420-425","source":"Crossref","is-referenced-by-count":43,"title":["Comparative clinical and airway inflammatory features of asthmatics with or without polyps"],"prefix":"10.4193","volume":"48","author":[{"given":"Lara","family":"Bilodeau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Eve","family":"Boulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Prince","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Boisvert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis-Philippe","family":"Boulet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2708","container-title":["Rhinology journal"],"original-title":[],"deposited":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T10:55:42Z","timestamp":1621508142000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.rhinologyjournal.com\/Abstract.php?id=918"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,12,1]]}},"URL":"https:\/\/doi.org\/10.4193\/rhino09.095","relation":{},"ISSN":["0300-0729"],"issn-type":[{"value":"0300-0729","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12,1]]}}}