{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:20:19Z","timestamp":1759335619682},"reference-count":0,"publisher":"Stichting Nase","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rhin"],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:p>BACKGROUND: E-cadherin and \u03b2-catenin are molecules that mediate cell-cell adhesion in normal epithelium. Aberrant expression of these adhesion molecules results in the loss of intercellular adhesion, with possible cell transformation and tumour progression. We determined the role of E-cadherin and \u03b2-catenin in the pathogenesis of sinonasal inverted papilloma (IP) and its malignant transformation. METHODS: We determined the expression of E-cadherin and \u03b2-catenin by immunohistochemistry in paraffin-embedded tissue of 21 subjects with nasal polyps, 56 with IPs, 7 IPs with dysplasia and 18 IPs with squamous cell carcinoma (SCC). The clinicopathological variables of the IPs with SCC correlated with the degree of expression of E-cadherin and \u03b2-catenin. RESULTS: The degree of expression of E-cadherin and \u03b2-catenin in the cell membrane was significantly lower in IPs with SCC than in nasal polyps and IPs. The degree of expression of \u03b2-catenin was significantly lower in IPs with SCC with a malignant proportion &gt; 50% compared to a malignant proportion \u2264 50%. However, there was no significant association between the degree of expression of E-cadherin and \u03b2-catenin and clinicopathological variables, such as age, gender, T stage, tumour differentiation, or SCC type (metachronous vs. synchronous). In addition, there was no significant relationship between recurrence or survival rate in IPs with SCC and the degree of expression of E-cadherin or \u03b2-catenin in the cell membrane or nuclear \u03b2-catenin. CONCLUSION: Decreased expression of E-cadherin and \u03b2-catenin in the cell membrane may be associated with carcinogenesis of IPs and help predict malignant transformation in sinonasal IPs.<\/jats:p>","DOI":"10.4193\/rhino10.214","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T15:33:05Z","timestamp":1621956785000},"page":"479-485","source":"Crossref","is-referenced-by-count":16,"title":["Altered expression of E-cadherin and \u03b2-catenin in malignant transformation of sinonasal inverted papillomas"],"prefix":"10.4193","volume":"49","author":[{"given":"B.S.","family":"Koo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.J.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.G.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.L.","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.K.","family":"Yeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.S.","family":"Rha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2708","container-title":["Rhinology journal"],"original-title":[],"deposited":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T15:33:06Z","timestamp":1621956786000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.rhinologyjournal.com\/Abstract.php?id=1019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,10,1]]}},"URL":"https:\/\/doi.org\/10.4193\/rhino10.214","relation":{},"ISSN":["0300-0729"],"issn-type":[{"value":"0300-0729","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10,1]]}}}