{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T12:15:00Z","timestamp":1747224900172,"version":"3.40.5"},"reference-count":22,"publisher":"Stichting Nase","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["RHINOL"],"abstract":"<jats:p>Background: Evidence regarding prevalence of COVID-19 related Olfactory dysfunction (OD) among ambulatory patients is highly variable due to heterogeneity in study population and measurement methods. Relatively few studies have longitudinally investigated OD in ambulatory patients with objective methods. Methods: We performed a longitudinal study to investigate OD among COVID-19 ambulatory patients compared to symptomatic controls who test negative. Out of 81 patients enrolled, 45 COVID-19 positive patients and an age- and sex-matched symptomatic control group completed the BSIT and a questionnaire about smell, taste and nasal symptoms. These were repeated at 1 month for all COVID-19 positive patients, and again at 3 months for those who exhibited persistent OD. Analysis was performed by mixed-effects linear and logistic regression. Results: 46.7% of COVID-19 patients compared to 3.8% of symptomatic controls exhibited OD at 1-week post diagnosis. At 1 month, 16.7%, (6 of 36), of COVID-19 patients had persistent OD. Mean improvement in BSIT score in COVID-19 patients between 1-week BSIT and 1 month follow-up was 2.0. OD did not correlate with nasal congestion. Conclusions: Ambulatory COVID-19 patients exhibited OD significantly more frequently than symptomatic controls. Most patients regained normal olfaction by 1 month. The BSIT is a simple validated and objective test to investigate the prevalence of OD in ambulatory patients. OD did not correlate with nasal congestion which suggests a congestion-independent mechanism of OD.<\/jats:p>","DOI":"10.4193\/rhinol\/21.034","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T20:25:53Z","timestamp":1628972753000},"page":"131-139","source":"Crossref","is-referenced-by-count":1,"title":["COVID-19 related olfactory dysfunction prevalence and natural history in ambulatory patients"],"prefix":"10.4193","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9267-1893","authenticated-orcid":false,"given":"D.R.","family":"Bacon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Onuorah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Murr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.A.","family":"Wiesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Oakes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.D.","family":"Thorp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Zanation","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.S.","family":"Ebert Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wohl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.A.","family":"Senior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.J.","family":"Kimple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2708","published-online":{"date-parts":[[2021,8,14]]},"reference":[{"key":"ref0","unstructured":"1. WHO Coronavirus Disease (COVID-19) Dashboard. WHO.int. https:\/\/covid19.who.int\/. Last modified February 1, 2021. Accessed on April 15, 2021."},{"key":"ref1","unstructured":"2. Coronavirus. WHO.int. https:\/\/www.who.int\/health-topics\/coronavirus#tab=tab_3. Accessed on April 15, 2021."},{"key":"ref2","unstructured":"3. Symptoms of Coronavirus. CDC.gov. https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/symptoms-testing\/symptoms.html. Last modified December 22, 2020. Accessed April 15, 2021."},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"4. Ottaviano G, Carecchio M, Scarpa B, Marchese-Ragona R. Olfactory and rhinological evaluations in SARS-CoV-2 patients complaining of olfactory loss. Rhinology. 2020;58(4):400-1.","DOI":"10.4193\/Rhin20.136"},{"issue":"4","key":"ref4","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1002\/lary.29286","article-title":"Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-analysis of 27,492 Patients","volume":"131","author":"Saniasiaya","year":"2020","unstructured":"5. Saniasiaya J, Islam MA, Abdullah B. Prevalence of Olfactory Dysfunction in Coronavirus Disease 2019 (COVID-19): A Meta-analysis of 27,492 Patients. Laryngoscope. 2020; 131(4): 865-878.","journal-title":"Laryngoscope"},{"issue":"2","key":"ref5","doi-asserted-by":"publisher","first-page":"102889","DOI":"10.1016\/j.amjoto.2020.102889","article-title":"Onset and duration of symptoms of loss of smell\/taste in patients with COVID-19: A systematic review","volume":"42","author":"Santos","year":"2021","unstructured":"6. Santos REA, Da Silva MG, Monte Silva MCB et al. Onset and duration of symptoms of loss of smell\/taste in patients with COVID-19: A systematic review. Am J Otolaryngol. 2021;42(2):102889.","journal-title":"Am J Otolaryngol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"117107","DOI":"10.1016\/j.jns.2020.117107","article-title":"Smell Dysfunction in COVID-19 Patients: More than a Yes-No Question","volume":"418","author":"Lima","year":"2020","unstructured":"7. Lima MA, Silva MTT, Oliveira RV, et al. Smell Dysfunction in COVID-19 Patients: More than a Yes-No Question. J Neurol Sci. 2020; 418: 117107.","journal-title":"J Neurol Sci"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1002\/alr.22688","article-title":"Intl","volume":"10","author":"Prajapati","year":"2020","unstructured":"8. Prajapati DP, Shahrvini B, MacDonald BV, et al. Association of Subjective Olfactory Dysfunction and 12-item Odor Identification Testing in Ambulatory COVID-19 Patients. Intl. Forum Allergy Rhinol. 2020; 10: 1209-1217.","journal-title":"Forum Allergy Rhinol"},{"issue":"10","key":"ref8","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1002\/alr.22680","article-title":"Intl","volume":"10","author":"Moein","year":"2020","unstructured":"9. Moein ST, Hashemian SMR, Tabarsi P, Doty RL. Prevalence and Reversibility of Smell Dysfunction Measured Psychotropically in a Cohort of COVID-19 Patients. Intl. Forum Allergy Rhinology. 2020; 10(10): 1127-1135.","journal-title":"Forum Allergy Rhinology"},{"issue":"5","key":"ref9","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1017\/cem.2020.420","article-title":"Self-Reported Anosmia and Dysgeusia as Key Symptoms of Coronavirus Disease 2019","volume":"22","author":"Lee","year":"2020","unstructured":"10. Lee DJ, Lockwood J, Das P, et al. Self-Reported Anosmia and Dysgeusia as Key Symptoms of Coronavirus Disease 2019. CJEM. 2020; 22(5): 595-602.","journal-title":"CJEM"},{"issue":"8","key":"ref10","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1001\/jamaoto.2020.1379","article-title":"Evolution of Altered Sense of Smell or Taste in Patients with Mildly Symptomatic COVID-19","volume":"146","author":"Boscolo-Rizzo","year":"2020","unstructured":"11. Boscolo-Rizzo P, Borsetto D, Fabbris C, et al. Evolution of Altered Sense of Smell or Taste in Patients with Mildly Symptomatic COVID-19. JAMA Otolaryngol Head Neck Surg. 2020; 146(8): 729-732.","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"7","key":"ref11","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1002\/alr.22579","article-title":"Intl","volume":"10","author":"Yan","year":"2020","unstructured":"12. Yan CH, Faraji F, Prajapati, et al. Association of Chemosensory Dysfunction and COVID-19 in Patients Presenting with Influenza-Like Symptoms. Intl. 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Psychophysical evaluation of chemosensory functions 5 weeks after olfactory loss due to COVID-19: a prospective cohort study on 72 patients. Eur Arch Otorhinolaryngol. 2021; 278(1): 101-108.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"15. Bertlich M, Stihl C, Lusebrink E et al. The course of subjective and objective chemosensory dysfunction in hospitalized patients with COVID-19: a 6-month follow-up. Eur Arch Otorhinolaryngol. 2021: 10;1-7.","DOI":"10.1007\/s00405-021-06796-4"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"16. Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR. Time scale for resolution of olfactory dysfunction in COVID-19. Rhinology. 2020;58(4):404-5.","DOI":"10.4193\/Rhin20.227"},{"issue":"11","key":"ref16","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1002\/lary.28957","article-title":"Evolution of Olfactory Disorders in COVID-19 Patients","volume":"130","author":"Gorzkowski","year":"2020","unstructured":"17. Gorzkowski V, Bevilacqua S, Charmillion A et al. Evolution of Olfactory Disorders in COVID-19 Patients. Laryngoscope. 2020; 130(11): 2667-2673.","journal-title":"Laryngoscope"},{"issue":"8","key":"ref17","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/alr.21964","article-title":"Intl","volume":"7","author":"Levy","year":"2017","unstructured":"18. Levy JM, Mace JC, Bodner TE, et al. Defining the minimal clinically important difference for olfactory outcomes in the surgical treatment of chronic rhinosinusitis. Intl. For Allergy Rhinol. 2017; 7(8): 821-826.","journal-title":"For Allergy Rhinol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1097\/00005537-199603000-00021","article-title":"Development of the 12-item Cross-Cultural Smell Identification Test (CC-SIT)","volume":"106","author":"Doty","year":"1996","unstructured":"19. Doty RL, Marcus A, Lee WW, et al. Development of the 12-item Cross-Cultural Smell Identification Test (CC-SIT). Laryngoscope. 1996; 106:353-6.","journal-title":"Laryngoscope"},{"issue":"12","key":"ref19","doi-asserted-by":"publisher","first-page":"2077","DOI":"10.1097\/01.mlg.0000187394.12264.d6","article-title":"A ChemoSensory Questionnaire for Patients Treated for Cancer of the Head and Neck","volume":"115","author":"Goldberg","year":"2005","unstructured":"20. Goldberg AN, Shea JA, Deems DA, et al. A ChemoSensory Questionnaire for Patients Treated for Cancer of the Head and Neck. Laryngoscope. 2005; 115(12): 2077-86.","journal-title":"Laryngoscope"},{"key":"ref20","unstructured":"21. People with Certain Medical Conditions. CDC.gov. https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/need-extra-precautions\/people-with-medical-conditions.html. Last updated December 21, 2020. Accessed July 15, 2020."},{"issue":"31","key":"ref21","doi-asserted-by":"publisher","first-page":"5801","DOI":"10.1126\/sciadv.abc5801","article-title":"Non-Neuronal Expression of SARS-CoV-2 Entry Genes in the Olfactory System Suggests Mechanisms Underlying COVID-19-Associated Anosmia","volume":"6","author":"Brann","year":"2020","unstructured":"22. Brann DH, Tsukahara T, Weinreb C, et al. Non-Neuronal Expression of SARS-CoV-2 Entry Genes in the Olfactory System Suggests Mechanisms Underlying COVID-19-Associated Anosmia. 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