{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T09:31:16Z","timestamp":1773480676591,"version":"3.50.1"},"reference-count":41,"publisher":"The Korean Physiological Society and The Korean Society of Pharmacology","issue":"6","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Korean J Physiol Pharmacol"],"published-print":{"date-parts":[[2011]]},"DOI":"10.4196\/kjpp.2011.15.6.327","type":"journal-article","created":{"date-parts":[[2012,1,11]],"date-time":"2012-01-11T01:24:52Z","timestamp":1326245092000},"page":"327","source":"Crossref","is-referenced-by-count":9,"title":["Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats"],"prefix":"10.4196","volume":"15","author":[{"given":"Majid","family":"Asiabanha","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, P.O.Box: 7515412578, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamreza","family":"Asadikaram","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Physiology Research Center, Kerman University of Medical Sciences, Kerman, P.O.Box: 7616914115, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Rahnema","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, P.O.Box: 7719617996, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Mahmoodi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, P.O.Box: 7719617996, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gholamhosein","family":"Hasanshahi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, P.O.Box: 7719617996, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, P.O.Box: 9816743463, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Khaksari","sequence":"additional","affiliation":[{"name":"Department of Physiology and Physiology Research Center, Kerman University of Medical Sciences, Kerman, P.O.Box: 7616914115, Iran."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2706","reference":[{"key":"10.4196\/kjpp.2011.15.6.327_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.2000.0740001.x","volume":"74","author":"Sastry","year":"2000","journal-title":"J Neurochem"},{"key":"10.4196\/kjpp.2011.15.6.327_ref2","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/35073667","volume":"410","author":"Kaul","year":"2001","journal-title":"Nature"},{"key":"10.4196\/kjpp.2011.15.6.327_ref3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jneuroim.2006.02.001","volume":"174","author":"Yin","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.4196\/kjpp.2011.15.6.327_ref4","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/jnr.20812","volume":"83","author":"Emeterio","year":"2006","journal-title":"J Neurosci Res"},{"key":"10.4196\/kjpp.2011.15.6.327_ref5","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/sj.bjp.0704364","volume":"134","author":"Boronat","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.4196\/kjpp.2011.15.6.327_ref6","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/0-306-47611-8_15","volume":"493","author":"Singhal","year":"2001","journal-title":"Adv Exp Med Biol"},{"key":"10.4196\/kjpp.2011.15.6.327_ref7","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1002\/hep.20428","volume":"40","author":"Jaume","year":"2004","journal-title":"Hepatology"},{"key":"10.4196\/kjpp.2011.15.6.327_ref8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/j.1471-4159.2006.04406.x","volume":"101","author":"Cunha-Oliveira","year":"2007","journal-title":"J Neurochem"},{"key":"10.4196\/kjpp.2011.15.6.327_ref9","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/00000542-200303000-00012","volume":"98","author":"Hitosugi","year":"2003","journal-title":"Anesthesiology"},{"key":"10.4196\/kjpp.2011.15.6.327_ref10","first-page":"186","volume":"66","author":"Schiff","year":"2002","journal-title":"Am J Pharm Educ"},{"key":"10.4196\/kjpp.2011.15.6.327_ref11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/13556210410001674095","volume":"9","author":"Karam","year":"2004","journal-title":"Addict Biol"},{"key":"10.4196\/kjpp.2011.15.6.327_ref12","first-page":"180","volume":"21","author":"Karam","year":"2008","journal-title":"Pak J Pharm Sci"},{"key":"10.4196\/kjpp.2011.15.6.327_ref13","first-page":"186","volume":"7","author":"Asadikaram","year":"2010","journal-title":"Iran J Immunol"},{"key":"10.4196\/kjpp.2011.15.6.327_ref14","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1073\/pnas.95.4.1601","volume":"95","author":"Ye","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.4196\/kjpp.2011.15.6.327_ref15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1556\/APhysiol.88.2001.3-4.5","volume":"88","author":"Mahmoudian","year":"2001","journal-title":"Acta Physiol Hung"},{"key":"10.4196\/kjpp.2011.15.6.327_ref16","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/CAD.0b013e3282ffd68d","volume":"19","author":"Newcomb","year":"2008","journal-title":"Anticancer Drugs"},{"key":"10.4196\/kjpp.2011.15.6.327_ref17","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1158\/0008-5472.CAN-06-4282","volume":"67","author":"Aneja","year":"2007","journal-title":"Cancer Res"},{"key":"10.4196\/kjpp.2011.15.6.327_ref18","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1016\/S0024-3205(02)01525-4","volume":"70","author":"Gao","year":"2002","journal-title":"Life Sci"},{"key":"10.4196\/kjpp.2011.15.6.327_ref19","first-page":"400","volume-title":"The Science and Practice of Pharmacy","author":"Venturella","year":"1995","edition":"19th ed"},{"key":"10.4196\/kjpp.2011.15.6.327_ref20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-2006-959447","volume":"60","author":"Buchbauer","year":"1994","journal-title":"Planta Med"},{"key":"10.4196\/kjpp.2011.15.6.327_ref21","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF02913315","volume":"22","author":"Akbarzadeh","year":"2007","journal-title":"Indian J Clin Biochem"},{"key":"10.4196\/kjpp.2011.15.6.327_ref22","doi-asserted-by":"crossref","first-page":"638467","DOI":"10.1155\/2008\/638467","volume":"2008","author":"Jafari Anarkooli","year":"2008","journal-title":"Exp Diabetes Res"},{"key":"10.4196\/kjpp.2011.15.6.327_ref23","first-page":"363","volume-title":"Annual prevalence of drug abuse","author":"Chawla","year":"2005"},{"key":"10.4196\/kjpp.2011.15.6.327_ref24","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1523\/JNEUROSCI.22-05-01914.2002","volume":"22","author":"Pu","year":"2002","journal-title":"J Neurosci"},{"key":"10.4196\/kjpp.2011.15.6.327_ref25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1152\/physrev.2001.81.1.299","volume":"81","author":"Williams","year":"2001","journal-title":"Physiol Rev"},{"key":"10.4196\/kjpp.2011.15.6.327_ref26","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1523\/JNEUROSCI.22-17-07650.2002","volume":"22","author":"Mao","year":"2002","journal-title":"J Neurosci"},{"key":"10.4196\/kjpp.2011.15.6.327_ref27","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00210-003-0801-9","volume":"368","author":"Garc\u00eda-Fuster","year":"2003","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.4196\/kjpp.2011.15.6.327_ref28","doi-asserted-by":"crossref","first-page":"11202","DOI":"10.1073\/pnas.93.20.11202","volume":"93","author":"Sklair-Tavron","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.4196\/kjpp.2011.15.6.327_ref29","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/syn.10146","volume":"46","author":"Robinson","year":"2002","journal-title":"Synapse"},{"key":"10.4196\/kjpp.2011.15.6.327_ref30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tox.2008.11.015","volume":"256","author":"Hsiao","year":"2009","journal-title":"Toxicology"},{"key":"10.4196\/kjpp.2011.15.6.327_ref31","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1164\/rccm.200611-1712OC","volume":"176","author":"Faulkner","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.4196\/kjpp.2011.15.6.327_ref32","first-page":"255","volume":"24","author":"Fuggetta","year":"2005","journal-title":"J Exp Clin Cancer Res"},{"key":"10.4196\/kjpp.2011.15.6.327_ref33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1479-5876-6-33","volume":"6","author":"Lang","year":"2008","journal-title":"J Transl Med"},{"key":"10.4196\/kjpp.2011.15.6.327_ref34","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1213\/ane.0b013e31817326a5","volume":"107","author":"Vagnerova","year":"2008","journal-title":"Anesth Analg"},{"key":"10.4196\/kjpp.2011.15.6.327_ref35","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1006\/bbrc.1998.9695","volume":"252","author":"Sueoka","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.4196\/kjpp.2011.15.6.327_ref36","first-page":"1033","volume":"5","author":"Maneckjee","year":"1994","journal-title":"Cell Growth Differ"},{"key":"10.4196\/kjpp.2011.15.6.327_ref37","first-page":"163","volume":"27","author":"Liu","year":"2009","journal-title":"Restor Neurol Neurosci"},{"key":"10.4196\/kjpp.2011.15.6.327_ref38","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jns.2007.01.033","volume":"257","author":"Sas","year":"2007","journal-title":"J Neurol Sci"},{"key":"10.4196\/kjpp.2011.15.6.327_ref39","doi-asserted-by":"crossref","first-page":"230458","DOI":"10.1155\/2008\/230458","volume":"2008","author":"Sima","year":"2008","journal-title":"Exp Diabetes Res"},{"key":"10.4196\/kjpp.2011.15.6.327_ref40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1089\/ars.2006.1458","volume":"9","author":"Nishikawa","year":"2007","journal-title":"Antioxid Redox Signal"},{"key":"10.4196\/kjpp.2011.15.6.327_ref41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4196\/kjpp.2010.14.2.99","volume":"14","author":"Seo","year":"2010","journal-title":"Korean J Physiol Pharmacol"}],"container-title":["The Korean Journal of Physiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.4196\/kjpp.2011.15.6.327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/synapse.koreamed.org\/pdf\/10.4196\/kjpp.2011.15.6.327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/synapse.koreamed.org\/DOIx.php?id=10.4196\/kjpp.2011.15.6.327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T05:49:19Z","timestamp":1561182559000},"score":1,"resource":{"primary":{"URL":"https:\/\/synapse.koreamed.org\/DOIx.php?id=10.4196\/kjpp.2011.15.6.327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.4196\/kjpp.2011.15.6.327","relation":{},"ISSN":["1226-4512","2093-3827"],"issn-type":[{"value":"1226-4512","type":"print"},{"value":"2093-3827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]}}}