{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T13:54:48Z","timestamp":1736776488878,"version":"3.33.0"},"reference-count":0,"publisher":"Canadian Society of Healthcare-Systems Pharmacy","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJHP"],"abstract":"<jats:p>Contexte : L\u2019\u00e9mergence de r\u00e9sistances aux antibiotiques a contribu\u00e9 \u00e0 cr\u00e9er des bact\u00e9ries multir\u00e9sistantes, et ceci constitue une pr\u00e9occupation majeure.\nObjectifs\u00a0: L\u2019objectif principal \u00e9tait d\u2019explorer l\u2019association possible entre la consommation d\u2019antibiotiques et l\u2019\u00e9mergence de r\u00e9sistance dans un centre hospitalier universitaire m\u00e8re-enfant. \nM\u00e9thode\u00a0: Il s\u2019agit d\u2019une \u00e9tude r\u00e9trospective men\u00e9e dans un centre hospitalier universitaire. Des couples antibiotique-bact\u00e9rie ont \u00e9t\u00e9 \u00e9tablis, en tenant compte du nombre d\u2019isolats, de l\u2019utilisation r\u00e9elle d\u2019antibiotique et de la pertinence clinique des couples. Pour chaque couple, une comparaison de deux variables (consommation d\u2019antibiotiques et pourcentage de r\u00e9sistance) a \u00e9t\u00e9 quantifi\u00e9e par un coefficient de Pearson. Trois analyses ont \u00e9t\u00e9 consid\u00e9r\u00e9es\u00a0: sans d\u00e9calage entre les donn\u00e9es d\u2019utilisation et de r\u00e9sistance, d\u00e9calage d\u2019un an et d\u00e9calage de deux ans.\nR\u00e9sultats\u00a0: Trente couples ont \u00e9t\u00e9 s\u00e9lectionn\u00e9s en h\u00e9mato-oncologie et 18 couples en n\u00e9onatologie. En h\u00e9mato-oncologie, six couples avaient une corr\u00e9lation positive (Pearson &gt; 0,7), deux couples impliquant le m\u00e9rop\u00e9nem, deux la ceftazidime et deux la pip\u00e9racilline-tazobactam. Dans trois cas, la corr\u00e9lation s\u2019observe sans d\u00e9calage entre les donn\u00e9es de\u00a0consommation et de r\u00e9sistance. En n\u00e9onatologie, trois couples avaient une corr\u00e9lation positive, un impliquant la vancomycine, un la cloxacilline et\u00a0un le m\u00e9rop\u00e9nem. \nConclusions\u00a0: Il est possible d\u2019explorer l\u2019association qui peut exister entre la consommation d\u2019antibiotiques et l\u2019\u00e9mergence de r\u00e9sistance dans un centre. L\u2019approche exploratoire reposait sur un traitement manuel des donn\u00e9es. Il pourrait \u00eatre int\u00e9ressant d\u2019envisager une approche syst\u00e9matique continue permettant la production automatique de corr\u00e9lations.\nABSTRACT\nBackground: The emergence of antibiotic resistance has contributed to the development of multidrug-resistant bacteria, which is a major\u00a0concern.\nObjectives: The primary objective was to explore the possible association between antibiotic use and the emergence of resistance in a mother-child university hospital.\nMethod: This retrospective study was conducted in a university hospital centre. Antibiotic-bacteria pairs were established, taking into account the number of isolates, actual antibiotic use, and clinical relevance. For each pair, a comparison of 2\u00a0variables (antibiotic utilization and rate of resistance) was quantified with the Pearson coefficient. Three analyses were conducted: no lag between utilization and resistance, 1-year lag, and 2-year lag.\nResults: Thirty antibiotic-bacteria pairs were selected from hematology-oncology and 18 from neonatology. In hematology-oncology, 6 pairs had a positive correlation (Pearson coefficient &gt; 0.7): 2 pairs involving meropenem, 2 involving ceftazidime, and 2 involving piperacillin-tazobactam. In 3 of these cases, there was no lag between consumption of antibiotics and presence of resistance. In neonatology, 3 antibiotic-bacteria pairs had a positive correlation, 1 each involving vancomycin, cloxacillin, and meropenem. \nConclusions: It is possible to explore the potential association between consumption of antibiotics and emergence of resistance in a particular centre. Our exploratory approach was based on manual data processing. It would be interesting to consider a continuous systematic approach, allowing automatic generation of correlations.<\/jats:p>","DOI":"10.4212\/cjhp.3183","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T01:16:16Z","timestamp":1657070176000},"page":"201-209","source":"Crossref","is-referenced-by-count":0,"title":["Exploration de l\u2019association possible entre la consommation d\u2019antibiotiques et l\u2019\u00e9mergence de r\u00e9sistance dans un centre hospitalier universitaire m\u00e8re-enfant"],"prefix":"10.4212","volume":"75","author":[{"given":"Aur\u00e9lie","family":"Bleuse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Roy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Lebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Ovetchkine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Bussi\u00e8res","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2732","published-online":{"date-parts":[[2022,7,4]]},"container-title":["Canadian Journal of Hospital Pharmacy"],"original-title":[],"link":[{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3183\/4678","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3183\/4696","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3183\/4678","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T01:16:16Z","timestamp":1657070176000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/view\/3183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,4]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,7,4]]}},"URL":"https:\/\/doi.org\/10.4212\/cjhp.3183","relation":{},"ISSN":["1920-2903","0008-4123"],"issn-type":[{"type":"electronic","value":"1920-2903"},{"type":"print","value":"0008-4123"}],"subject":[],"published":{"date-parts":[[2022,7,4]]}}}