{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:15:15Z","timestamp":1788894915512,"version":"build-2803163510"},"reference-count":0,"publisher":"Canadian Society of Healthcare-Systems Pharmacy","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Hosp Pharm"],"abstract":"<jats:p>Background: Drug poisoning, either intentional or non-intentional, is a frequent diagnosis in the emergency department (ED), necessitating patient management from multiple services.\nObjective: To describe the drug poisonings seen in the ED of a large academic urban hospital.\nMethods: This retrospective descriptive study used 3 years of data (2018\u20132020) abstracted from the hospital\u2019s electronic medical record system and linked to validated, coded extracts from the Canadian Institute for Health Information Discharge Abstract Database. Patients with a diagnosis of acute drug poisoning who presented to the ED were identified on the basis of International Statistical Classification of Diseases and Related Health Problems, 10th revision, Canada (ICD-10-CA) codes, and data were collected for demographic characteristics, the drugs involved, in-hospital management, and inpatient outcomes. Patients with diagnosis of an acute drug reaction, inebriation, or nondrug or in-hospital poisoning were excluded. Data were stratified and analyzed in relation to the intent of drug poisoning.\nResults: A total of 2983 visits for drug poisoning, involving 2211 unique patients (mean age 38.3 [standard deviation 16.2] years, 54.7% female), were included, yielding an overall incidence rate of 15.7 drug poisonings per 1000 ED visits (8.1 intentional, 6.4 non-intentional, and 1.3 unknown intent). Among the 1505 intentional drug poisonings, the most prevalent drug sources were antidepressants (n = 405, 26.9%), benzodiazepines (n = 375, 24.9%), and acetaminophen (n = 329, 21.9%); in contrast, opioids (n = 594, 48.1%) were most prevalent for the 1236 non-intentional poisonings. For 716 (24.0%) of the poisoning visits, the patient was admitted to acute care services, and the in-hospital mortality rate was 1.0% (n = 31). In addition, 111 patients (9.0%) with non-intentional drug poisoning left against medical advice. Finally, for 772 (25.9%) of the poisoning visits, the patient returned to the ED after discharge with a subsequent drug poisoning.\nConclusions: Drug poisonings are a common cause of visits to urban EDs. They are rarely fatal but are associated with substantial utilization of hospital resources and considerable recidivism.\nKeywords: emergency, poisoning, overdose, opioids\nR\u00c9SUM\u00c9\nContexte : L\u2019intoxication m\u00e9dicamenteuse, intentionnelle ou non, est un diagnostic fr\u00e9quent dans le service des urgences (SU); elle n\u00e9cessite la prise en charge des patients par plusieurs services.\nObjectif : D\u00e9crire les intoxications m\u00e9dicamenteuses observ\u00e9es dans le SU d\u2019un grand h\u00f4pital universitaire urbain.M\u00e9thodologie : Pour cette \u00e9tude r\u00e9trospective et descriptive, des donn\u00e9es contenues dans le syst\u00e8me de dossiers m\u00e9dicaux \u00e9lectroniques de l\u2019h\u00f4pital et li\u00e9es \u00e0 des extraits valid\u00e9s et cod\u00e9s de la base de donn\u00e9es sur les cong\u00e9s des patients de l\u2019Institut canadien d\u2019information sur la sant\u00e9 pendant 3 ans (2018-2020) ont \u00e9t\u00e9 utilis\u00e9es. Les patients ayant re\u00e7u un diagnostic d\u2019intoxication m\u00e9dicamenteuse aigu\u00eb qui se sont pr\u00e9sent\u00e9s \u00e0 l\u2019urgence ont \u00e9t\u00e9 identifi\u00e9s sur la base des codes de la Classification statistique internationale des maladies et des probl\u00e8mes de sant\u00e9 connexes, 10e version, Canada (CIM-10-CA), et des donn\u00e9es ont \u00e9t\u00e9 recueillies pour les caract\u00e9ristiques d\u00e9mographiques, les m\u00e9dicaments impliqu\u00e9s, la prise en charge \u00e0 l\u2019h\u00f4pital et les r\u00e9sultats pour les patients hospitalis\u00e9s. Les patients pr\u00e9sentant un diagnostic de r\u00e9action m\u00e9dicamenteuse aigu\u00eb, d\u2019\u00e9bri\u00e9t\u00e9 ou d\u2019intoxication non m\u00e9dicamenteuse ou \u00e0 l\u2019h\u00f4pital ont \u00e9t\u00e9 exclus. Les donn\u00e9es ont \u00e9t\u00e9 stratifi\u00e9es et analys\u00e9es en fonction de l\u2019intention de l\u2019empoisonnement m\u00e9dicamenteux.\nR\u00e9sultats : Au total, 2983 cas mettant en cause 2211 patients (\u00e2ge moyen 38,3 [\u00e9cart type 16,2] ans, dont 54,7 % de femmes) ont \u00e9t\u00e9 inclus; les r\u00e9sultats ont donn\u00e9 un taux d\u2019incidence global de 15,7 intoxications m\u00e9dicamenteuses pour 1000 visites au SU (8,1 intentionnelles; 6,4 non intentionnelles; et 1,3 intention inconnue). Parmi les 1505 intoxications m\u00e9dicamenteuses intentionnelles, les m\u00e9dicaments les plus r\u00e9pandues \u00e9taient les antid\u00e9presseurs (n = 405, 26,9 %), les benzodiaz\u00e9pines (n = 375, 24,9 %) et l\u2019ac\u00e9taminoph\u00e8ne (n = 329, 21,9 %); les opio\u00efdes (n = 594, 48,1 %) \u00e9taient les plus r\u00e9pandus parmi les 1236 intoxications non intentionnelles. Dans 716 des cas (24,0 %), le patient a \u00e9t\u00e9 admis dans les services de soins aigus. Le taux de mortalit\u00e9 hospitali\u00e8re \u00e9tait de 1,0 % (n = 31). Par ailleurs, 111 patients (9,0 %) pr\u00e9sentant une intoxication m\u00e9dicamenteuse non intentionnelle ont quitt\u00e9 l\u2019h\u00f4pital contre avis m\u00e9dical. Enfin, dans 772 des cas d\u2019intoxication (25,9 %), le patient est retourn\u00e9 \u00e0 l\u2019urgence apr\u00e8s sa sortie \u00e0 cause d\u2019une intoxication m\u00e9dicamenteuse ult\u00e9rieure.\nConclusions : Les intoxications m\u00e9dicamenteuses sont une cause fr\u00e9quente de visites dans les SU urbains. Ils sont rarement mortels, mais sont associ\u00e9s \u00e0 une utilisation importante des ressources hospitali\u00e8res et \u00e0 une r\u00e9cidive consid\u00e9rable.Mots-cl\u00e9s : urgence, empoisonnement, surdose, opio\u00efdes<\/jats:p>","DOI":"10.4212\/cjhp.3454","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T13:58:10Z","timestamp":1712757490000},"source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of Drug Poisonings Seen in the Emergency Department of an Urban Hospital"],"prefix":"10.4212","volume":"77","author":[{"given":"Matthew","family":"Bell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Holbrook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erich","family":"Hanel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlynn","family":"Rigg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2732","published-online":{"date-parts":[[2024,4,10]]},"container-title":["Canadian Journal of Hospital Pharmacy"],"original-title":[],"link":[{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3454\/5269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3454\/5273","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3454\/5269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:15:20Z","timestamp":1753118120000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/view\/3454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,10]]},"references-count":0,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2024,6,12]]}},"URL":"https:\/\/doi.org\/10.4212\/cjhp.3454","relation":{},"ISSN":["1920-2903","0008-4123"],"issn-type":[{"value":"1920-2903","type":"electronic"},{"value":"0008-4123","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,10]]},"article-number":"e3454"}}