{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T11:17:37Z","timestamp":1772709457672,"version":"3.50.1"},"reference-count":0,"publisher":"Canadian Society of Healthcare-Systems Pharmacy","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Can J Hosp Pharm"],"abstract":"<jats:p>Background: Despite growing interest in understanding the challenges faced by multidisciplinary health teams during the COVID-19 pandemic, there is a lack of studies specifically focusing on changes in pharmacist interventions and drug-related problems.\nObjectives: To analyze and compare the interventions performed by pharmacists during comprehensive medication management in the adult intensive care unit and general internal medicine ward of the University Hospital of the University of S\u00e3o Paulo, Brazil, for defined periods before the onset of the COVID-19 pandemic and during the pandemic itself.\nMethods: All pharmacist interventions performed in relation to inpatient prescriptions from March to December 2019 (before the pandemic) and from March to December 2021 (during the pandemic) were collected and tabulated. These interventions were then classified according to the Pharmaceutical Care Network Europe (PCNE) system, version 9.1, and categorized based on first-level codes of the Anatomical Therapeutic Chemical classification system.\nResults: The analysis revealed substantial changes in the patterns of pharmacist interventions and the therapeutic classes of drugs for COVID- 19-positive and COVID-19-negative patients during the pandemic relative to patients in the pre-pandemic period. Among COVID-19-positive patients, interventions were predominantly related to enhancing patient safety (PCNE code P2), drug selection (C1), dose selection (C3), prescribing and dispensing processes (C5), the drug-use process (C6), and patient transfers between different levels of care (C8). The drug-related problems addressed by pharmacist interventions primarily involved COVID-19- positive patients in the pandemic period and were related to systemic hormonal preparations (excluding sex hormones and insulins), anti-infective agents for systemic use, nervous system and drugs for the blood and blood- forming organs.\nConclusion: The results of this study highlight the adaptability and competence of pharmacists in responding to critical scenarios such as the COVID-19 pandemic. These scenarios are characterized by new work dynamics, the hiring of additional professionals, an increase in the number of beds, the rapid evolution of evidence-based information, and drug shortages that necessitate the use of alternative medications. Pharmacists play a crucial role in ensuring patient safety during these difficult times.\nKey words: clinical pharmacy, pharmacist interventions, pandemic, COVID-19\nR\u00c9SUM\u00c9\nContexte : Malgr\u00e9 un int\u00e9r\u00eat croissant pour la compr\u00e9hension des d\u00e9fis auxquels les \u00e9quipes de sant\u00e9 multidisciplinaires ont \u00e9t\u00e9 confront\u00e9es pendant la pand\u00e9mie de COVID-19, peu d\u2019\u00e9tudes portent sur les changements chez les interventions des pharmaciens et les probl\u00e8mes li\u00e9s aux m\u00e9dicaments en particulier.\nObjectifs : Analyser et comparer les interventions r\u00e9alis\u00e9es par les pharmaciens lors de la gestion globale des m\u00e9dicaments dans l\u2019unit\u00e9 de soins intensifs pour adultes et le service de m\u00e9decine interne g\u00e9n\u00e9rale de l\u2019h\u00f4pital universitaire de l\u2019Universit\u00e9 de S\u00e3o Paulo, Br\u00e9sil, pendant des p\u00e9riodes d\u00e9finies avant le d\u00e9but de la pand\u00e9mie de COVID-19 et pendant la pand\u00e9mie elle-m\u00eame.\nM\u00e9thodologie : Toutes les interventions des pharmaciens r\u00e9alis\u00e9es en lien avec les prescriptions hospitali\u00e8res de mars \u00e0 d\u00e9cembre 2019 (avant la pand\u00e9mie) et de mars \u00e0 d\u00e9cembre 2021 (pendant la pand\u00e9mie) ont \u00e9t\u00e9 collect\u00e9es et compil\u00e9es. Ces interventions ont ensuite \u00e9t\u00e9 class\u00e9es selon le syst\u00e8me du Pharmaceutical Care Network Europe (PCNE), version 9.1, et cat\u00e9goris\u00e9es sur la base des codes de premier niveau du syst\u00e8me de classification anatomique, th\u00e9rapeutique et chimique.\nR\u00e9sultats : L\u2019analyse a r\u00e9v\u00e9l\u00e9 des changements substantiels dans les types d\u2019intervention des pharmaciens et dans les classes th\u00e9rapeutiques dem\u00e9dicaments pour les patients positifs pour la COVID-19 et n\u00e9gatifs pour la COVID-19 pendant la pand\u00e9mie par rapport aux patients d\u2019avant la pand\u00e9mie. Parmi les patients positifs pour la COVID-19, les interventions \u00e9taient principalement li\u00e9es \u00e0 l\u2019am\u00e9lioration de la s\u00e9curit\u00e9 des patients (code PCNE P2), au choix des m\u00e9dicaments (C1), \u00e0 la s\u00e9lection des doses (C3), au processus de prescription et de d\u00e9livrance (C5), au processus d\u2019utilisation des m\u00e9dicaments (C6), et aux transferts de patients entre diff\u00e9rents niveaux de soins (C8). Les probl\u00e8mes li\u00e9s aux m\u00e9dicaments trait\u00e9s par les interventions des pharmaciens concernaient principalement les patients positifs pour la COVID-19 pendant la p\u00e9riode de la pand\u00e9mie et se rapportaient aux pr\u00e9parations hormonales syst\u00e9miques (\u00e0 l\u2019exclusion des hormones sexuelles et des insulines), aux agents anti-infectieux \u00e0 usage syst\u00e9mique, au syst\u00e8me nerveux ainsi qu\u2019au sang et aux organes h\u00e9matopo\u00ef\u00e9tiques.\nConclusion : Les r\u00e9sultats de cette \u00e9tude mettent en \u00e9vidence l\u2019adaptabilit\u00e9 et la comp\u00e9tence des pharmaciens pour r\u00e9pondre \u00e0 des sc\u00e9narios critiques tels que la pand\u00e9mie de COVID-19. Ces sc\u00e9narios se caract\u00e9risent par une nouvelle dynamique de travail, l\u2019embauche de professionnels suppl\u00e9mentaires, une augmentation du nombre de lits, l\u2019\u00e9volution rapide des informations fond\u00e9es sur des donn\u00e9es probantes et des p\u00e9nuries de m\u00e9dicaments n\u00e9cessitant le recours \u00e0 des m\u00e9dicaments alternatifs. Les pharmaciens jouent un r\u00f4le crucial pour assurer la s\u00e9curit\u00e9 des patients pendant ces p\u00e9riodes difficiles.\nMots-cl\u00e9s : pharmacie clinique, interventions des pharmaciens, pand\u00e9mie, COVID-19<\/jats:p>","DOI":"10.4212\/cjhp.3514","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T10:36:07Z","timestamp":1720607767000},"source":"Crossref","is-referenced-by-count":1,"title":["Impact of the COVID-19 Pandemic on Pharmacist Interventions: A Retrospective Study with Inpatients in a University Hospital"],"prefix":"10.4212","volume":"77","author":[{"given":"Guilherme Cezar","family":"Ambr\u00f3sio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1760-8181","authenticated-orcid":false,"given":"Karine Dal","family":"Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5811-6485","authenticated-orcid":false,"given":"Vinicius Albuquerque","family":"Moreira de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-3826","authenticated-orcid":false,"given":"Michelle Garcia Discacciatii","family":"Discacciatii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-3378","authenticated-orcid":false,"given":"Ana","family":"Campa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2732","published-online":{"date-parts":[[2024,7,10]]},"container-title":["Canadian Journal of Hospital Pharmacy"],"original-title":[],"link":[{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3514\/5354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3514\/5365","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3514\/5354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:23:18Z","timestamp":1753118598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/view\/3514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,9,11]]}},"URL":"https:\/\/doi.org\/10.4212\/cjhp.3514","relation":{},"ISSN":["1920-2903","0008-4123"],"issn-type":[{"value":"1920-2903","type":"electronic"},{"value":"0008-4123","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,10]]},"article-number":"e3514"}}