{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T10:27:29Z","timestamp":1788863249787,"version":"build-2803163510"},"reference-count":0,"publisher":"Canadian Society of Healthcare-Systems Pharmacy","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CJHP"],"abstract":"<jats:p>Background: Despite ample evidence of benefit, adherence to secondary prevention medication therapy after acute coronary syndrome (ACS) is often suboptimal. Hospital pharmacists are uniquely positioned to improve adherence by providing medication education at discharge.\nObjective: To determine whether a standardized counselling intervention at hospital discharge significantly improved patients\u2019 adherence to cardiovascular medications following ACS.\nMethods: This single-centre, prospective, nonrandomized comparative study enrolled patients with a primary diagnosis of ACS (January 2014 to July 2015). Patients who received standardized discharge counselling from a clinical pharmacist were compared with patients who did not receive counselling. At 30 days and 1 year after discharge, follow-up patient surveys were conducted and community pharmacy refill data were obtained. Adherence was assessed using pharmacy refill data and patient self-reporting for 5 targeted medications: acetylsalicylic acid, P2Y purinoceptor 12 (P2Y12) inhibitors, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, \u03b2-blockers, and statins. Thirty-day and 1-year medication utilization, cardiovascular readmission rates, and all-cause mortality were also assessed. Results: Of the 259 patients enrolled, 88 (34.0%) received discharge counselling. Medication data were obtained for 253 patients (97.7%) at 30 days and 242 patients (93.4%) at 1 year. At 1 year after discharge, there were no statistically significant differences between patients who did and did not receive counselling in terms of rates of nonadherence (11.9% versus 18.4%, p = 0.19), cardiovascular readmission (17.6% versus 22.3%, p = 0.42), and all-cause mortality (3.4% versus 4.2%, p &gt; 0.99). Overall medication nonadherence was 2.8% (7\/253) at 30 days and 16.1% (39\/242) at 1 year.\nConclusions: Discharge medication counselling provided by hospital pharmacists after ACS was not associated with significantly better medication adherence at 1 year. Higher-quality evidence is needed to determine the most effective and practical interventions to ensure that patients adhere to their medication regimens and achieve positive outcomes after ACS.\nR\u00c9SUM\u00c9\nContexte : Malgr\u00e9 l\u2019abondance de preuves d\u00e9montrant ses avantages, l\u2019adh\u00e9sion \u00e0 la pharmacoth\u00e9rapie de pr\u00e9vention secondaire apr\u00e8s les syndromes coronariens aigus (SCA) est souvent \u00ab sous-optimale \u00bb. Les pharmaciens d\u2019h\u00f4pitaux occupent une place unique pour am\u00e9liorer l\u2019adh\u00e9sion en expliquant au patient l\u2019usage des m\u00e9dicaments au moment du cong\u00e9 hospitalier.\nObjectif : D\u00e9terminer si une consultation standardis\u00e9e au moment du cong\u00e9 hospitalier am\u00e9liore significativement ou non l\u2019adh\u00e9sion \u00e0 la pharmacoth\u00e9rapie cardiovasculaire apr\u00e8s les SCA.\nM\u00e9thodes : Des patients ayant re\u00e7u un diagnostic primaire de SCA (de janvier 2014 \u00e0 juillet 2015) ont \u00e9t\u00e9 inscrits pour participer \u00e0 cette \u00e9tude comparative unicentrique prospective et non randomis\u00e9e. Ceux ayant b\u00e9n\u00e9fici\u00e9 d\u2019une consultation standardis\u00e9e par un pharmacien clinicien au moment du cong\u00e9 ont \u00e9t\u00e9 compar\u00e9s aux patients qui n\u2019en n\u2019avaient pas re\u00e7u. Trente jours et un an apr\u00e8s le cong\u00e9, des enqu\u00eates de suivi du patient ont \u00e9t\u00e9 men\u00e9es et les donn\u00e9es de renouvellement d\u2019ordonnance des pharmacies communautaires ont \u00e9t\u00e9 recueillies. L\u2019adh\u00e9sion a \u00e9t\u00e9 \u00e9valu\u00e9e \u00e0 l\u2019aide des donn\u00e9es de renouvellement d\u2019ordonnance et celles rapport\u00e9es par le patient pour cinq m\u00e9dicaments cibl\u00e9s : l\u2019acide ac\u00e9tylsalicylique, les inhibiteurs P2Y purinoceptor 12 (P2Y12), les inhibiteurs de l\u2019enzyme de conversion de l\u2019angiotensine ou les antagonistes des r\u00e9cepteurs de l\u2019angiotensine II, les antagonistes \u03b2 et les statines. L\u2019utilisation des m\u00e9dicaments \u00e0 30 jours et \u00e0 un an, le taux de r\u00e9admission en raison d\u2019un trouble cardiovasculaire et le taux de mortalit\u00e9 toutes causes confondues ont \u00e9galement fait l\u2019objet d\u2019une \u00e9valuation.\nR\u00e9sultats : Sur les 259 patients inscrits, 88 (34 %) ont b\u00e9n\u00e9fici\u00e9 d\u2019une consultation au moment du cong\u00e9. Des donn\u00e9es concernant la m\u00e9dication de 253 patients ont \u00e9t\u00e9 obtenues (97,7 %) \u00e0 30 jours et pour 242 patients (93,4 %) \u00e0 un an. Un an apr\u00e8s le cong\u00e9, aucune diff\u00e9rence statistique significative n\u2019a \u00e9t\u00e9 observ\u00e9e entre les patients ayant re\u00e7u ou non une consultation concernant la non-adh\u00e9sion (11,9 % contre 18,4 %, p = 0,19), la r\u00e9admission en raison d\u2019un trouble cardiovasculaire (17,6 % contre 22,3 %, p = 0,42), et le taux de mortalit\u00e9 toutes causes confondues (3,4 % contre 4,2 %, p &gt; 0,99). La non-adh\u00e9sion aux m\u00e9dicaments de mani\u00e8re g\u00e9n\u00e9rale se montait \u00e0 2,8 % (7\/253) \u00e0 30 jours et \u00e0 16,1 % (39\/242) \u00e0 un an.\nConclusions : La consultation concernant la m\u00e9dication donn\u00e9e par les pharmaciens d\u2019h\u00f4pitaux au moment du cong\u00e9 apr\u00e8s les SCA n\u2019\u00e9tait pas associ\u00e9e \u00e0 un meilleur suivi de la m\u00e9dication un an plus tard. Des donn\u00e9es probantes de meilleure qualit\u00e9 sont n\u00e9cessaires pour d\u00e9terminer les interventions les plus efficaces et pratiques pour que les patients adh\u00e8rent \u00e0 leur r\u00e9gime m\u00e9dicamenteux et qu\u2019ils obtiennent des r\u00e9sultats positifs apr\u00e8s les SCA.<\/jats:p>","DOI":"10.4212\/cjhp.v74i4.3198","type":"journal-article","created":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T04:42:21Z","timestamp":1633840941000},"source":"Crossref","is-referenced-by-count":5,"title":["Pharmacist Intervention to Improve Medication Adherence in Patients with Acute Coronary Syndrome: The PRIMA-ACS Study"],"prefix":"10.4212","volume":"74","author":[{"given":"Heather L","family":"Neville","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Killen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Callaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2732","published-online":{"date-parts":[[2021,9,28]]},"container-title":["Canadian Journal of Hospital Pharmacy"],"original-title":[],"link":[{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3198\/4531","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3198\/4547","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3198\/4554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/download\/3198\/4531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T04:42:21Z","timestamp":1633840941000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cjhp-online.ca\/index.php\/cjhp\/article\/view\/3198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,28]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,9,28]]}},"URL":"https:\/\/doi.org\/10.4212\/cjhp.v74i4.3198","relation":{},"ISSN":["1920-2903","0008-4123"],"issn-type":[{"value":"1920-2903","type":"electronic"},{"value":"0008-4123","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9,28]]}}}