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Despite being proposed as a common regulatory factor for both muscle and bone, the impact of BMP-7 on human muscle health has not been thoroughly investigated.Methods: This cross-sectional study involved 182 community-dwelling older adults who underwent a comprehensive geriatric assessment in South Korea. Sarcopenia was diagnosed using Asian-specific cutoffs, and serum BMP-7 levels were quantified via enzyme immunoassay.Results: The mean age of the participants was 72.2\u00b17.3 years, with 62.6% being female. After adjustments for confounders, serum BMP-7 levels were not significantly different between individuals with and without sarcopenia, nor were there differences based on skeletal muscle mass, strength, or physical performance levels (p=0.423 to 0.681). Likewise, no correlations were detected between circulating BMP-7 levels and any sarcopenia assessment metrics such as skeletal muscle index, grip strength, gait speed, or chair stand completion times (p=0.127 to 0.577). No significant associations were observed between increases in serum BMP-7 concentrations and the risk of sarcopenia or poor muscle phenotypes (p=0.431 to 0.712). Stratifying participants into quartiles based on serum BMP-7 levels also indicated no differences in sarcopenia-related parameters (p=0.663 to 0.996).Conclusion: Despite experimental evidence supporting BMP-7\u2019s role in muscle metabolism, this study found no significant association between serum BMP-7 levels and clinical indicators of muscle health in older adults. These findings challenge the utility of serum BMP-7 as a biomarker for sarcopenia in this demographic.<\/jats:p>","DOI":"10.4235\/agmr.24.0153","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T05:50:01Z","timestamp":1731304201000},"page":"75-82","update-policy":"https:\/\/doi.org\/10.4235\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating BMP-7 Level is Independent of Sarcopenia in Older Asian Adults"],"prefix":"10.4235","volume":"29","author":[{"given":"Ahin","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji 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