{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:06:37Z","timestamp":1774490797271,"version":"3.50.1"},"reference-count":39,"publisher":"Scientific Research Publishing, Inc.","issue":"03","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.scirp.org"],"crossmark-restriction":true},"short-container-title":["OJI"],"published-print":{"date-parts":[[2024]]},"DOI":"10.4236\/oji.2024.143006","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T03:54:08Z","timestamp":1727409248000},"page":"60-86","update-policy":"https:\/\/doi.org\/10.4236\/scirp.2020.crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["The First Pilot Epigenetic Type Improvement of Neuropsychiatric Symptoms in a Polymorphic Dopamine D2 (-DRD2\/ANKK (Taq1A)), OPRM1 (A\/G), DRD3 (C\/T), and MAOA (4R) Compromised Preadolescence Male with Putative PANDAS\/CANS: Positive Clinical Outcome with Precision-Guided DNA Testing and Pro-Dopamine Regulation (KB220) and Antibacterial Therapies"],"prefix":"10.4236","volume":"14","author":[{"given":"Kenneth","family":"Blum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Elman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Hanna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Baron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashim","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Kazmi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jag","family":"Khalsa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debasis","family":"Bagchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra D.","family":"Badgaiyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward J.","family":"Modestino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A.","family":"Dennen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric R.","family":"Braverman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdalla","family":"Bowirrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerthy","family":"Sunder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Foojan","family":"Zeine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul R.","family":"Carney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai-Uwe","family":"Lewandowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Sharafshah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aryeh R.","family":"Pollack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panayotis K.","family":"Thanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2751","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-0179-4-13"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2021.20091347"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19116395"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.15761\/jsin.1000163"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-79838-7_17"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2018.04.013"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/da.20669"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.4.883"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22378"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/b978-0-444-52014-2.00046-x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.11.040"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2015.1045871"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159\/000534061"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8883962"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.15761\/jsin.1000221"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2023.120809"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11030212"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.23937\/2378-3656\/1410125"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.01.001"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12091385"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.2741\/4509"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4236\/oji.2022.123004"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01700-4"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.3390\/children9020155"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.27729"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23020967"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-022-01401-z"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1002\/jca.22023"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-022-00707-6"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s10880-022-09926-0"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007\/s10578-021-01135-4"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.psycr.2022.100074"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6105.1000139"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.2147\/prbm.s292958"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x17666191118125702"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12020321"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1177\/014107689608900711"},{"key":"ref38","unstructured":"Blum, K., Modestino, E.J., Gondre-Lewis, M.C., Baron, D., Steinberg, B., Thanos, P.K., <i>et al<\/i>. (2018) Pro-Dopamine Regulator (KB220) A Fifty Year Sojourn to Combat Reward Deficiency Syndrome (RDS): Evidence Based Bibliography (Annotated). <i>CPQ Neurology and Psychology<\/i>, 1. https:\/\/www.cientperiodique.com\/journal\/fulltext\/CPQNP\/1\/2\/13"},{"key":"ref39","unstructured":"Blum, K., Baron, D., McLaughlin, T., Thanos, P.K., Dennen, C., Ceccanti, M., <i>et al<\/i>. (2022) Summary Document Research on RDS Anti-Addiction Modeling: Annotated Bibliography. <i>Journal of Systems and Integrative Neuroscience<\/i>, 8, 2-35."}],"container-title":["Open Journal of Immunology"],"original-title":[],"link":[{"URL":"https:\/\/www.scirp.org\/journal\/paperinformation?paperid=136367","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.scirp.org\/xml\/136367.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.scirp.org\/journal\/paperinformation?paperid=136367","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T01:16:55Z","timestamp":1774487815000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.scirp.org\/journal\/paperinformation?paperid=136367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":39,"journal-issue":{"issue":"03","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4236\/oji.2024.143006","relation":{},"ISSN":["2162-450X","2162-4526"],"issn-type":[{"value":"2162-450X","type":"print"},{"value":"2162-4526","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}