{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:44:25Z","timestamp":1777383865430,"version":"3.51.4"},"reference-count":25,"publisher":"Baishideng Publishing Group Inc.","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Diabetes"],"abstract":"<jats:p>Diabetes mellitus is one of the most common causes of chronic kidney disease. Kidney involvement in patients with diabetes has a wide spectrum of clinical presentations ranging from asymptomatic to overt proteinuria and kidney failure. The development of kidney disease in diabetes is associated with structural changes in multiple kidney compartments, such as the vascular system and glomeruli. Glomerular alterations include thickening of the glomerular basement membrane, loss of podocytes, and segmental mesangiolysis, which may lead to microaneurysms and the development of pathognomonic Kimmelstiel-Wilson nodules. Beyond lesions directly related to diabetes, awareness of the possible coexistence of nondiabetic kidney disease in patients with diabetes is increasing. These nondiabetic lesions include focal segmental glomerulosclerosis, IgA nephropathy, and other primary or secondary renal disorders. Differential diagnosis of these conditions is crucial in guiding clinical management and therapeutic approaches. However, the relationship between diabetes and the kidney is bidirectional; thus, new-onset diabetes may also occur as a complication of the treatment in patients with renal diseases. Here, we review the complex and multifaceted correlation between diabetes and kidney diseases and discuss clinical presentation and course, differential diagnosis, and therapeutic oppor-tunities offered by novel drugs. <\/jats:p>","DOI":"10.4239\/wjd.v14.i10.1532","type":"journal-article","created":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T21:13:10Z","timestamp":1696713190000},"page":"1532-1540","source":"Crossref","is-referenced-by-count":8,"title":["Effects of insulin aspart and metformin on gestational diabetes mellitus and inflammatory markers"],"prefix":"10.4239","volume":"14","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bang-Ruo","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2023,10,15]]},"reference":[{"key":"B1","unstructured":"Quintanilla Rodriguez BS, Mahdy H.   Gestational Diabetes. 2022 Sep 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2014.12.006"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1530\/EC-21-0227"},{"key":"B4","unstructured":"Hartling L, Dryden DM, Guthrie A, Muise M, Vandermeer B, Aktary WM, Pasichnyk D, Seida JC, Donovan L. Screening and diagnosing gestational diabetes mellitus. Evid Rep Technol Assess (Full Rep) 2012; 1-327"},{"key":"B5","unstructured":"Jawad F, Ejaz K. Gestational diabetes mellitus in South Asia: Epidemiology. J Pak Med Assoc 2016; 66: S5-S7"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2019.05.001"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113342"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.09.004"},{"key":"B9","unstructured":"Rubin R, Khanna NR, McIver LA.   Aspart Insulin. 2022 Nov 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.163202"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.3805"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010564.pub2"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1550480"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.4.10307"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2174\/1381612827666210125155428"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17249517"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2174\/1573399815666190712193828"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2020_512"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2021-067946"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.285"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-018-0696-8"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4882061"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-017-4336-x"},{"key":"B24","unstructured":"Wang W, Fan Y, Lin Q. Metformin combined with insulin aspart for ameliorating blood glucose levels and maternal and neonatal outcomes in women with gestational diabetes mellitus and chronic hypertension. Am J Transl Res 2021; 13: 5596-5602"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.07.002"}],"container-title":["World Journal of Diabetes"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v14\/i10\/1532.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v14\/i10\/1532.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T08:04:52Z","timestamp":1696838692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v14\/i10\/1532.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,15]]},"references-count":25,"journal-issue":{"issue":"10"},"URL":"https:\/\/doi.org\/10.4239\/wjd.v14.i10.1532","relation":{},"ISSN":["1948-9358"],"issn-type":[{"value":"1948-9358","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,15]]}}}