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Previous trials confirmed the positive influence of GLP-1 agonists on \u03b2 cell function. However, hypoglycemia unawareness and dysregulated glucagon response have been previously reported in patients with recurrent hypoglycemia using GLP-1 agonists. Jin et al  found that the source of glucagon dysregulation due to GLP-1 agonists resides in the gut. Plausible explanations could be gut nervous system dysregulation or gut microbiota disruption. This review evaluates the potential of GLP-1 agonists in managing type 1 diabetes, particularly focusing on their impact on glycemic control, weight management, and glucagon dysregulation. We provide a broader insight into the problem of type 1 diabetes mellitus management in the light of recent findings and provide future research directions.<\/jats:p>","DOI":"10.4239\/wjd.v15.i11.2167","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T05:27:40Z","timestamp":1729056460000},"page":"2167-2172","source":"Crossref","is-referenced-by-count":1,"title":["Glucagon-like peptide-1 agonists: Role of the gut in hypoglycemia unawareness, and the rationale in type 1 diabetes"],"prefix":"10.4239","volume":"15","author":[{"given":"Hyder O","family":"Mirghani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2021.08.006"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-022-00477-x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcjd.2022.07.006"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-0373"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1032822"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2018.0384"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.975880"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.03.001"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/zxz179"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad471"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-075681"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.008649"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12291"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1210\/jcemcr\/luad040"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00520.2015"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051573"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05891-x"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.08.016"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2174\/15733998113099990064"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-0124"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3584"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3070"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2337\/db20-0998"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v15.i8.1764"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa645"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15009"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2010"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1697"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.4.958"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0164"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1541"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2302677"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13486"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1177\/2050640620925968"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0355-7"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00019-X"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.08.003"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02032-23"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29857"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13911"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0691"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v15.i2.133"}],"container-title":["World Journal of Diabetes"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v15\/i11\/2167.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v15\/i11\/2167.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T05:27:47Z","timestamp":1729056467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v15\/i11\/2167.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,15]]},"references-count":42,"journal-issue":{"issue":"11"},"URL":"https:\/\/doi.org\/10.4239\/wjd.v15.i11.2167","relation":{},"ISSN":["1948-9358"],"issn-type":[{"value":"1948-9358","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11,15]]}}}