{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T00:18:16Z","timestamp":1721953096317},"reference-count":33,"publisher":"Baishideng Publishing Group Inc.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Diabetes"],"abstract":"BACKGROUND<\/jats:p>\n Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes mellitus that usually presents within the first 6 mo of life. Patients often enter remission within several months, although relapse can occur later in life. Mutations in the ABCC8 gene, which encodes the sulfonylurea receptor 1 of the ATP-sensitive potassium channel in pancreatic beta cells, are associated with TNDM and permanent neonatal diabetes. This study describes a novel de novo c.3880C>T heterozygous ABCC8 variant that causes TNDM and can be treated with sulf-onylurea therapy.<\/jats:p>\n CASE SUMMARY<\/jats:p>\n We retrospectively analyzed 2 Chinese patients with TNDM who were diagnosed, treated, or referred for follow-up between September 2017 and September 2023. The patients were tested for mutations using targeted next-generation sequencing. Patients with neonatal diabetes mellitus caused by a c.3880C>T heterozygous missense variant in the ABCC8 gene have not been reported before. Both children had an onset of post-infectious diabetic ketoacidosis, which is worth noting. At a follow-up visit after discontinuing insulin injection, oral glyburide was found to be effective with no adverse reactions.<\/jats:p>\n CONCLUSION<\/jats:p>\n Early genetic testing of neonatal diabetes mellitus aids in accurate diagnosis and treatment and helps avoid daily insulin injections that may cause pain.<\/jats:p>","DOI":"10.4239\/wjd.v15.i8.1811","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T19:57:57Z","timestamp":1721937477000},"page":"1811-1819","source":"Crossref","is-referenced-by-count":0,"title":["Transient diabetes mellitus with ABCC8 variant successfully treated with sulfonylurea: Two case reports and review of 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