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Histone deacetylases (HDACs) are critical epigenetic regulators that catalyze the removal of acetyl or acyl groups from lysine residues in proteins, thereby modulating various biological processes, including transcription, apoptosis, and metabolism. Nevertheless, the precise roles of HDACs in diabetic wound healing remain largely unexplored. Thus, the current review describes the pivotal roles of HDACs in diabetic wound healing, focusing on their regulation of inflammatory responses, vascular dysfunction, and epithelial renewal, which are critical events in wound healing. 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