{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:36:37Z","timestamp":1793144197903,"version":"4.5.0"},"reference-count":19,"publisher":"Baishideng Publishing Group Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Diabetes"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) play a key role in managing type 2 diabetes mellitus (T2DM). Transitioning between different GLP-1RA has been proposed as a treatment strategy.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To investigate switching patterns between GLP-1RA and their impact on glycemic control.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>A retrospective study involving patients with T2DM who initiated GLP-1RA therapy between 2009 and 2021 and transitioned to another GLP-1RA. Baseline glycated hemoglobin (HbA1c) was defined as the most recent measurement within 1 year prior to switching, and follow-up HbA1c was the first measurement recorded 4-15 months post-switch.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Among 70654 patients initiating GLP-1RA therapy, 18047 (25.5%) switched regimens. In the 13970 patients with available HbA1c, levels decreased from 8.5% \u00b1 1.6% to 7.6% \u00b1 1.4% (P  &lt; 0.001). HbA1c decreased in 78.3% (10943\/13970) of these patients, with the most frequent improvement observed in those switching from daily to weekly GLP-1RA (81%, 5582\/6890).<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Switching between GLP-1RAs can serve as a practical alternative to treatment intensification for effectively managing T2DM.<\/jats:p>","DOI":"10.4239\/wjd.v16.i11.112999","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T02:10:51Z","timestamp":1763086251000},"source":"Crossref","is-referenced-by-count":4,"title":["Glucagon-like peptide 1 receptor agonists switching patterns in type two diabetes: A retrospective real-world study"],"prefix":"10.4239","volume":"16","author":[{"given":"Sameer","family":"Kassem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buthaina","family":"Khalaila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nili","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Zaina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101102"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.13731"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15828"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3070"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/dci22-0034"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2174\/0113816128375766250720234005"},{"key":"B7","unstructured":"Bailey TS. Clinical Efficacy of Once-weekly Glucagonlike Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes. J Fam Pract 2018; S14-S24"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-S009"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.08.045"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2025.05.024"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-2260"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60659-0"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12596"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1592\/phco.29.pt2.33S"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12980"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12285"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-021-01010-4"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0417"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30024-X"}],"container-title":["World Journal of Diabetes"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v16\/i11\/112999.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v16\/i11\/112999.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T02:11:26Z","timestamp":1763086286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-9358\/full\/v16\/i11\/112999.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,15]]},"references-count":19,"journal-issue":{"issue":"11"},"alternative-id":["112999"],"URL":"https:\/\/doi.org\/10.4239\/wjd.v16.i11.112999","relation":{},"ISSN":["1948-9358"],"issn-type":[{"value":"1948-9358","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,15]]}}}