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Elevated levels of CRP and hs-CRP have been consistently associated with increased risk of these complications, reflecting ongoing inflammatory processes that contribute to endothelial dysfunction and tissue damage. Furthermore, CAR and CLR, which combine CRP with albumin and lymphocyte counts respectively, offer a more nuanced understanding of the inflammatory and immune response in T2DM patients. While individual studies have demonstrated the clinical relevance of these biomarkers in predicting disease onset and progression, further investigation is needed to establish their utility in clinical practice. This review highlights the potential of these biomarkers for enhancing early detection, risk stratification, and personalized management of diabetic patients, ultimately aiming to improve outcomes and reduce the burden of diabetic chronic microvascular complications.<\/jats:p>","DOI":"10.4239\/wjd.v16.i12.113237","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T04:31:50Z","timestamp":1765513910000},"source":"Crossref","is-referenced-by-count":11,"title":["Serum C-reactive protein and C-reactive protein derived markers in diabetic microvascular complications"],"prefix":"10.4239","volume":"16","author":[{"given":"Burcin Meryem","family":"Atak Tel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atiqa","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulali","family":"Aktas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2012.00170"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3706508"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11101958"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-40987-8"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-017-0159-5"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2217\/bmm-2018-0346"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.33490\/jkm.v10i3.1593"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6823-14-74"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11656"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.11.2016"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155642"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02207-0"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2237-y"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/srep26740"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2022-003197"},{"key":"B16","unstructured":"Liu Q, Jiang CY, Chen BX, Zhao W, Meng D. 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