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Recurrent hypoglycemia predisposes the development of impaired hypoglycemia awareness, a condition underpinned by complex pathophysiological processes, encompassing central nervous system adaptations and several hormonal interactions, including a potential role for glucagon-like peptide-1 (GLP-1) in paracrine and endocrine vias. Experimental evidence indicates that GLP-1 may impair hypoglycemic counterregulation by disrupting the sympathoadrenal system and promoting somatostatin release in pancreatic \u03b4-cells, which inhibits glucagon secretion from neighboring \u03b1-cells. However, current trials evaluating GLP-1 receptor agonists (GLP-1 RAs) in T1DM patients have shown promising benefits in reducing insulin requirements and body weight, without increasing the risk of hypoglycemia. Further research is essential to elucidate the specific roles of GLP-1 and GLP-1 RAs in modulating glucagon secretion and the sympathetic-adrenal reflex, and their impact on hypoglycemia unawareness in T1DM patients.<\/jats:p>","DOI":"10.4239\/wjd.v16.i2.99928","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T02:12:23Z","timestamp":1735524743000},"source":"Crossref","is-referenced-by-count":3,"title":["Glucagon-like peptide-1 and impaired counterregulatory responses to hypoglycemia in type 1 diabetes"],"prefix":"10.4239","volume":"16","author":[{"given":"Gabriel Reis","family":"Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabr\u00edcio Freire","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.5.1245"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2480"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1902"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.3.724"},{"key":"B5","unstructured":"de Galan BE, Schouwenberg BJ, Tack CJ, Smits P. 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