{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T17:20:50Z","timestamp":1784913650834,"version":"3.55.0"},"reference-count":37,"publisher":"Baishideng Publishing Group Inc.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Diabetes"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Type 2 diabetes mellitus (T2DM) is a metabolic disorder linked to high blood glucose and gut dysbiosis. Probiotics like Lactobacillus rhamnosus  LRa05 may improve glycemic control and gut microbiota.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To explore the impact of LRa05 with hypoglycemic medications on glycemic control and intestinal flora in T2DM patients with gut dysbiosis.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>Seventy-six participants were randomly assigned to receive either LRa05 (0.1 g 2 \u00d7 1010 CFU) (n  = 38) or a placebo (n  = 38) for 12 weeks. Baseline characteristics were recorded, and changes in glycated hemoglobin, fasting blood glucose, and other biochemical indices were assessed using repeated measures one-way analysis of variance. Additionally, gut microbiota diversity was analyzed through species accumulation and alpha and beta diversity metrics.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>The intervention group showed statistically significant improvements in lipid profiles, particularly in high-density lipoprotein cholesterol levels, which increased significantly over time (P  &lt; 0.001). Additionally, fasting blood glucose was significantly reduced in the LRa05 group compared with the placebo group (P  &lt; 0.001).  No significant changes were observed in glycated hemoglobin, insulin sensitivity, or systemic inflammatory markers such as C-reactive protein. Furthermore, gut microbiota analysis revealed significant shifts in composition following the intervention, particularly an increase in Bifidobacterium  and a decrease in Bacillota , indicating beneficial effects on gut health.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>This study demonstrated that the combination of Lactobacillus rhamnosus  LRa05 and hypoglycemic medications positively impacted glycemic control, specifically reflected in improved levels of high-density lipoprotein and fasting blood glucose. Additionally, significant alterations in gut microbiota composition were observed in patients with T2DM, indicating a potential synergistic effect between gut health and blood glucose regulation.<\/jats:p>","DOI":"10.4239\/wjd.v16.i7.106821","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T02:08:26Z","timestamp":1752545306000},"source":"Crossref","is-referenced-by-count":5,"title":["<i>Lactobacillus rhamnosus<\/i> LRa05 on glycemic control and gut microbiota in patients with type 2 diabetes"],"prefix":"10.4239","volume":"16","author":[{"given":"Lin","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bo","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Jing","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4729-5"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2015.1024661"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2024.07.017"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.834485"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13250"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5110276"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9631435"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2016.1252712"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/nbu.12334"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.04.015"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517000289"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2023.1105694"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1163\/18762891-bja00022"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5190846"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264291"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093211"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/nu12041107"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1017\/s0007114500001124"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.07.013"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132121"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.23650"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/nu12071921"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/nu10060773"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030671"},{"key":"B26","unstructured":"Mazloom Z, Yousefinejad A, Dabbaghmanesh MH. 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