{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T03:58:58Z","timestamp":1769054338120,"version":"3.49.0"},"reference-count":37,"publisher":"Baishideng Publishing Group Inc.","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Diabetes"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Diabetic foot ulcer (DFU) is a common and serious complication among individuals with diabetes. However, the co-occurrence of DFU with overlap syndrome, particularly involving anti-synthetase syndrome (ASS) and systemic sclerosis (SSc), is exceptionally rare.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>We report a case of overlap syndrome (ASS and SSc) with diabetes manifesting as biped gangrene. The patient, a 60-year-old female, presented with painful ulcers on both heels that had persisted for nine months. She was diagnosed with DFU, which was likely attributable to SSc, suboptimal long-term glycemic control, and glucocorticoid therapy. Following four months of treatment, the patient demonstrated significant improvement and was subsequently discharged. At the one-year follow-up, the patient developed new cyanotic ulcers on the right 4th and 5th toes ten months post-discharge that resolved completely within 3 months following conservative management. The four-year follow-up revealed persistent intermittent cyanosis without ulcer recurrence, although progressive interstitial lung disease necessitated prolonged bed rest.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>SSc-related foot ulcers demonstrate favorable outcomes when managed with conventional wound care combined with vasoactive agents.<\/jats:p>","DOI":"10.4239\/wjd.v16.i9.109597","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T13:00:38Z","timestamp":1757509238000},"source":"Crossref","is-referenced-by-count":1,"title":["Diabetic foot ulcer with overlap syndrome: A case report and review of 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