{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:14:39Z","timestamp":1791645279785,"version":"4.3.4"},"reference-count":31,"publisher":"Baishideng Publishing Group Inc.","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Diabetes"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Fasting glucose and glycated hemoglobin (HbA1c) were used to diagnose gestational diabetes during the coronavirus disease 2019 (COVID-19) pandemic.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To determine whether the diagnostic criteria used during the COVID-19 pandemic may play a role outside the pandemic.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>From May 2022 to July 2024, 354 females with an altered 50-g oral glucose tolerance test (OGTT), the usual diagnostic test (100-g OGTT), and the alternative diagnostic (A) criteria (fasting glucose \u2265 95 mg\/dL and\/or HbA1c \u2265 5.7%) were tested simultaneously, resulting in four different groups: OGTT+\/A+ (n  = 20); OGTT+\/A- (n  = 60); OGTT-\/A+ (n  = 24); and OGTT-\/A- (n  = 250). Groups were compared for clinical characteristics and obstetric and perinatal outcomes.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Sensitivity of the alternative criteria was 25% and specificity was 91.2%. Body mass index (BMI) was similar from the OGTT-\/A+ and OGTT+\/A+ groups (30.1 \u00b1 6.3 kg\/m2 and 32.7 \u00b1 5.3 kg\/m2, respectively) and significantly higher from the OGTT+\/A- and OGTT-\/A- groups (26.8 \u00b1 5.1 kg\/m2 and 25.6 \u00b1 5.0 kg\/m2, respectively). The between-group differences were similar for the respective rates of large for gestational age (LGA) infants (OGTT+\/A+: 38.9%, OGTT+\/A-: 11.8%, OGTT-\/A+: 29.4%, OGTT-\/A-: 12.4%; P  = 0.028). In the regression analysis a history of macrosomia [odds ratio (OR) = 7.948, 95% confidence interval (95%CI): 2.269-27.842; P  = 0.001] and higher pregestational BMI (OR = 1.069, 95%CI: 1.002-1.140; P =  0.042) independently increased the risk of LGA.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Despite insufficient validity to replace the OGTT, alternative criteria identify a group of patients with a higher risk profile and adverse perinatal outcomes who could benefit for health interventions.<\/jats:p>","DOI":"10.4239\/wjd.v17.i1.112882","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T02:59:46Z","timestamp":1768359586000},"source":"Crossref","is-referenced-by-count":1,"title":["Role of fasting glucose and glycated hemoglobin for gestational diabetes mellitus diagnosis: A prospective 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