{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:32:32Z","timestamp":1787031152808,"version":"build-2736575974"},"reference-count":38,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Surg"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence (POR) of Crohn\u2019s disease (CD). However, its prognostic value is uncertain, in part, due to difficulties studying it non-invasively.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To evaluate the prognostic value of pre-operative radiographic mesenteric parameters for early endoscopic POR (ePOR).<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>We conducted a retrospective cohort study of CD subjects \u2265 12 years who underwent ileocecal or small bowel resection between 1\/1\/2007 to 12\/31\/2021 with computerized tomography abdomen\/pelvis \u2264 6 months pre-operatively and underwent ileocolonoscopy \u2264 15 months post-operatively. Visceral adipose tissue (VAT) volume (cm3), ratio of VAT:subcutaneous adipose tissue (SAT) volume, VAT radiodensity, and ratio of VAT:SAT radiodensity were generated semiautomatically. Mesenteric lymphadenopathy (LAD, largest lymph node &gt; 10 mm) and severe vasa recta (VR) engorgement (diameter of the VR supplying diseased bowel \u2265 2 \u00d7 VR supplying healthy bowel) were derived manually. The primary outcome was early ePOR (Rutgeert\u2019s score \u2265 i2 on first endoscopy \u2264 15 months post-operatively) and the secondary outcome was ePOR severity (Rutgeert\u2019s score i0-4). Regression analyses were performed adjusting for demographic and disease-related characteristics to calculate adjusted odds ratio (aOR) and 95% confidence interval (CI).<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>Of the 139 subjects included, 45% of subjects developed early ePOR (n  = 63). VAT radiodensity (aOR 0.59, 95%CI: 0.38-0.90) and VAT:SAT radiodensity (aOR 8.54, 95%CI: 1.48-49.28) were associated with early ePOR, whereas, VAT volume (aOR 1.23, 95%CI: 0.78-1.95), VAT:SAT volume (aOR 0.80, 95%CI: 0.53-1.20), severe VR engorgement (aOR 1.53, 95%CI: 0.64-3.66), and mesenteric LAD (aOR 1.59, 95%CI: 0.67-3.79) were not. Similar results were observed for severity of ePOR.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>VAT radiodensity is potentially a novel non-invasive prognostic imaging marker to help risk stratify CD patients for POR.<\/jats:p>","DOI":"10.4240\/wjgs.v16.i3.740","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:44:12Z","timestamp":1711010652000},"page":"740-750","source":"Crossref","is-referenced-by-count":4,"title":["Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn\u2019s 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Computational Pathology Approach To Identify Micro And Macroscopic Features of Uninvolved Ileum Predictive Of Postoperative Recurrence In Crohn\u2019s Disease. Digestive Diseases Week. 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