{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:49:51Z","timestamp":1791906591379,"version":"4.3.4"},"reference-count":49,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Surg"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Colorectal cancer is a major global health challenge that predominantly affects older people. Surgical management, despite advancements, requires careful consideration of preoperative patient status for optimal outcomes.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To summarize existing evidence on the association of frailty with short-term postoperative outcomes in patients undergoing colorectal cancer surgery.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>A literature search was conducted using PubMed, EMBASE and Scopus databases for observational studies in adult patients aged \u2265 18 years undergoing planned or elective colorectal surgery for primary carcinoma and\/or secondary metastasis. Only studies that conducted frailty assessment using recognized frailty assessment tools and had a comparator group, comprising nonfrail patients, were included. Pooled effect sizes were reported as weighted mean difference or relative risk (RR) with 95% confidence intervals (CIs).<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>A total of 24 studies were included. Compared with nonfrail patients, frailty was associated with an increased risk of mortality at 30 d (RR: 1.99, 95%CI: 1.47\u20132.69), at 90 d (RR: 4.76, 95%CI: 1.56\u201314.6) and at 1 year (RR: 5.73, 95%CI: 2.74\u201312.0) of follow up. Frail patients had an increased risk of any complications (RR: 1.81, 95%CI: 1.57\u20132.10) as well as major complications (Clavien\u2013Dindo classification grade \u2265 III) (RR: 2.87, 95%CI: 1.65\u20134.99) compared with the control group. The risk of reoperation (RR: 1.18, 95%CI: 1.07\u20131.31), readmission (RR: 1.70, 95%CI: 1.36\u20132.12), need for blood transfusion (RR: 1.67, 95%CI: 1.52\u20131.85), wound complications (RR: 1.49, 95%CI: 1.11\u20131.99), delirium (RR: 4.60, 95%CI: 2.31\u20139.16), risk of prolonged hospitalization (RR: 2.09, 95%CI: 1.22\u20133.60) and discharge to a skilled nursing facility or rehabilitation center (RR: 3.19, 95%CI: 2.0\u20135.08) was all higher in frail patients.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>Frailty in colorectal cancer surgery patients was associated with more complications, longer hospital stays, higher reoperation risk, and increased mortality. Integrating frailty assessment appears crucial for tailored surgical management.<\/jats:p>","DOI":"10.4240\/wjgs.v16.i3.893","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T08:44:12Z","timestamp":1711010652000},"page":"893-906","source":"Crossref","is-referenced-by-count":22,"title":["Impact of frailty on short-term postoperative outcomes in patients undergoing colorectal cancer surgery: A systematic review and meta-analysis"],"prefix":"10.4240","volume":"16","author":[{"given":"Yao","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xia","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Jing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.5114\/pg.2018.81072"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.12703\/P6-108"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2018.1557343"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916277"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2010.08.009"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/57.5.m283"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1159\/000382061"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtocrr.2022.100414"},{"key":"B9","unstructured":"Tsai HH, Yu JC, Hsu HM, Chu CH, Hong ZJ, Feng AC, Fu CY, Dai MS, Liao GS. 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