{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T09:26:41Z","timestamp":1775899601915,"version":"3.50.1"},"reference-count":36,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Surg"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Appendiceal mucinous neoplasms (AMNs), although not classified as rare, are relatively uncommon tumors most often discovered incidentally during colorectal surgery. Accurate identification of AMNs is difficult due to non-specific symptoms, overlapping tumor markers with other conditions, and the potential for misdiagnosis. This underscores the urgent need for precision in diagnosis to prevent severe complications.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>This case report describes the unexpected discovery and treatment of a low-grade AMN (LAMN) in a 74-year-old man undergoing laparoscopic hemicolectomy for transverse colon adenocarcinoma (AC). Preoperatively, non-specific gastrointestinal symptoms and elevated tumor markers masked the presence of AMN. The tumor, presumed to be an AMN peritoneal cyst intraoperatively, was confirmed as LAMN through histopathological examination. The neoplasm exhibited mucin accumulation and a distinct immunohistochemical profile: Positive for Homeobox protein CDX-2 , Cytokeratin 20, special AT-rich sequence-binding protein 2, and Mucin 2 but negative for cytokeratin 7 and Paired box gene 8. This profile aids in distinguishing appendiceal and ovarian mucinous tumors. Postoperative recovery was uncomplicated, and the patient initiated adjuvant chemotherapy for the colon AC.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>This case highlights the diagnostic complexity of AMNs, emphasizing the need for vigilant identification to avert potential complications, such as pseudomyxoma peritonei.<\/jats:p>","DOI":"10.4240\/wjgs.v16.i3.944","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T12:44:12Z","timestamp":1711025052000},"page":"944-954","source":"Crossref","is-referenced-by-count":5,"title":["Mucinous neoplasm of the appendix: A case report and review of literature"],"prefix":"10.4240","volume":"16","author":[{"given":"Hao-Cheng","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Cheng","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta-Wei","family":"Pu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruei-Yu","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Yang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je-Ming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1177\/102490791101800303"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/bf02235492"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/bf02068082"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10589"},{"key":"B5","unstructured":"COLLINS DC. 71,000 HUMAN APPENDIX SPECIMENS. 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