{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:21:14Z","timestamp":1719534074520},"reference-count":35,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Surg"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Hepatitis is a systemic disease that often results in various comorbidities. Meta-bolic disorders, the most common comorbidities in clinical practice, were selected for this study.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate the causal relationship between comorbidities and hepatitis trea-tment outcomes.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>A total of 23583378 single nucleotide polymorphisms from 1248743 cases and related summaries of genome-wide association studies were obtained from online public databases. A two-sample Mendelian randomization (MR) was performed to investigate causality between exposure [type 2 diabetes mellitus (T2D), hyperlipidemia, and hypertension] and outcome (chronic hepatitis B or C in-fections).<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>The data supported the causal relationship between comorbidities and hepatitis infections, which will affect the severity of hepatitis progression and will also provide a reference for clinical researchers. All three exposures showed a link with progression of both hepatitis B (T2D, P  = 0.851; hyperlipidemia, P  = 0.596; and hypertension, P  = 0.346) and hepatitis C (T2D, P  = 0.298; hyperlipidemia, P  = 0.141; and hypertension, P  = 0.035).<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>The results of MR support a possible causal relationship between different ex-posures (T2D, hyperlipidemia, and hypertension) and chronic hepatitis progression; however, the potential mechanisms still need to be elucidated.<\/jats:p>","DOI":"10.4240\/wjgs.v16.i6.1775","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T14:38:00Z","timestamp":1719499080000},"page":"1775-1790","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic disorders and hepatitis: Insights from a Mendelian randomization study"],"prefix":"10.4240","volume":"16","author":[{"given":"Ling-Bo","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Rui","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao-Li","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"B1","unstructured":"World Health Organization.   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