{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:57:09Z","timestamp":1780055829531,"version":"3.54.0"},"reference-count":29,"publisher":"Baishideng Publishing Group Inc.","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Surg"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>The Chinese medicine Yangyin Huowei mixture (YYHWM) exhibits good clinical efficacy in the treatment of chronic atrophic gastritis (CAG), but the mechanisms underlying its activity remain unclear.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate the therapeutic effects of YYHWM and its underlying mechanisms in a CAG rat model.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>Sprague-Dawley rats were allocated into control, model, vitacoenzyme, and low, medium, and high-dose YYHWM groups. CAG was induced in rats using N-methyl-N\u2032-nitro-N-nitrosoguanidine, ranitidine hydrochloride, hunger and satiety perturbation, and ethanol gavage. Following an 8-wk intervention period, stomach samples were taken, stained, and examined for histopathological changes. ELISA was utilized to quantify serum levels of PG-I, PG-II, G-17, IL-1\u03b2, IL-6, and TNF-\u03b1. Western blot analysis was performed to evaluate protein expression of IL-10, JAK1, and STAT3.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>The model group showed gastric mucosal layer disruption and inflammatory cell infiltration. Compared with the blank control group, serum levels of PGI, PGII, and G-17 in the model group were significantly reduced (82.41 \u00b1 3.53 vs  38.52 \u00b1 1.71, 23.06 \u00b1 0.96 vs  11.06 \u00b1 0.70, and 493.09 \u00b1 12.17 vs  225.52 \u00b1 17.44, P  &lt; 0.01 for all), whereas those of IL-1\u03b2, IL-6, and TNF-\u03b1 were significantly increased (30.15 \u00b1 3.07 vs  80.98 \u00b1 4.47, 69.05 \u00b1 12.72 vs  110.85 \u00b1 6.68, and 209.24 \u00b1 11.62 vs  313.37 \u00b1 36.77, P  &lt; 0.01 for all), and the protein levels of IL-10, JAK1, and STAT3 were higher in gastric mucosal tissues (0.47 \u00b1 0.10 vs  1.11 \u00b1 0.09, 0.49 \u00b1 0.05 vs  0.99 \u00b1 0.07, and 0.24 \u00b1 0.05 vs  1.04 \u00b1 0.14, P  &lt; 0.01 for all). Compared with the model group, high-dose YYHWM treatment significantly improved the gastric mucosal tissue damage, increased the levels of PGI, PGII, and G-17 (38.52 \u00b1 1.71 vs  50.41 \u00b1 3.53, 11.06 \u00b1 0.70 vs  15.33 \u00b1 1.24, and 225.52 \u00b1 17.44 vs  329.22 \u00b1 29.11, P  &lt; 0.01 for all), decreased the levels of IL-1\u03b2, IL-6, and TNF-\u03b1 (80.98 \u00b1 4.47 vs  61.56 \u00b1 4.02, 110.85 \u00b1 6.68 vs  89.20 \u00b1 8.48, and 313.37 \u00b1 36.77 vs  267.30 \u00b1 9.31, P  &lt; 0.01 for all), and evidently decreased the protein levels of IL-10 and STAT3 in gastric mucosal tissues (1.11 \u00b1 0.09 vs  0.19 \u00b1 0.07 and 1.04 \u00b1 0.14 vs  0.55 \u00b1 0.09, P  &lt; 0.01 for both).<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>YYHWM reduces the release of inflammatory factors by inhibiting the IL-10\/JAK1\/STAT3 pathway, alleviating gastric mucosal damage, and enhancing gastric secretory function, thereby ameliorating CAG development and cancer transformation.<\/jats:p>","DOI":"10.4240\/wjgs.v16.i7.2296","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:52:46Z","timestamp":1721609566000},"page":"2296-2307","source":"Crossref","is-referenced-by-count":8,"title":["Yangyin Huowei mixture alleviates chronic atrophic gastritis by inhibiting the IL-10\/JAK1\/STAT3 pathway"],"prefix":"10.4240","volume":"16","author":[{"given":"Shan-Shan","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Ming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin-Fang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000033480"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112338-20211010-00777"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.07.058"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2017.5258"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032378"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1159\/000528168"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1674-070X.2023.05.013"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1003-8914.2016.10.032"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.14163\/j.cnki.11-5547\/r.2016.13.141"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117608"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1158\/2767-9764.CRC-23-0302"},{"key":"B13","unstructured":"Correa P, Shiao YH. Phenotypic and genotypic events in gastric carcinogenesis. Cancer Res 1994; 54: 1941s-1943s"},{"key":"B14","unstructured":"Qian CS, Lv CY, Li QD, Yanghu QY, Jiang YR, Zheng X, Li Q. Analysis on the treatment of Ye tianshi\u2019s \"stomach soup\". Zhongyiyao Tongbao 2022; 21: 25-26, 32"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14561"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282263"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1155377"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2023.111162"},{"key":"B19","unstructured":"Chen L, Qian Y, Guo M, Liu Y, Li J, Wu M, Zhang Y, Wang Y, Peng X, Zhan X. Autologous ex vivo expanded NK cells combined with PD-1 inhibitor improved ascitic fluid immune microenvironment of peritoneal metastatic pancreatic cancer: a case study. Am J Transl Res 2023; 15: 316-323"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1002\/iid3.746"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7850324"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2200335"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.993483"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15072163"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.28355"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioac163"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12010123"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076461"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1080\/21655979.2022.2048984"}],"container-title":["World Journal of Gastrointestinal Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v16\/i7\/2296.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v16\/i7\/2296.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:55:27Z","timestamp":1721609727000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v16\/i7\/2296.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,27]]},"references-count":29,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.4240\/wjgs.v16.i7.2296","relation":{},"ISSN":["1948-9366"],"issn-type":[{"value":"1948-9366","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7,27]]}}}