{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:04:24Z","timestamp":1793862264033,"version":"4.6.1"},"reference-count":28,"publisher":"Baishideng Publishing Group Inc.","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Surg"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Pediatric appendicitis is a common cause of abdominal pain in children and is recognized as a significant surgical emergency. A prompt and accurate diagnosis is essential to prevent complications such as perforation and peritonitis.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To investigate the predictive value of the systemic immune-inflammation index (SII) combined with the pediatric appendicitis score (PAS) for the assessment of disease severity and surgical outcomes in children aged 5 years and older with appendicitis.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>Clinical data of 104 children diagnosed with acute appendicitis were analyzed. The participants were categorized into the acute appendicitis group and chronic appendicitis group based on disease presentation and further stratified into the good prognosis group and poor prognosis group based on prognosis. The SII and PAS were measured, and a joint model using the combined SII and PAS was constructed to predict disease severity and surgical outcomes.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>Significant differences were observed in the SII and PAS parameters between the acute appendicitis group and chronic appendicitis group. Correlation analysis showed associations among the SII, PAS, and disease severity, with the combined SII and PAS model demonstrating significant predictive value for assessing disease severity [aera under the curve (AUC) = 0.914] and predicting surgical outcomes (AUC = 0.857) in children aged 5 years and older with appendicitis.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>The study findings support the potential of integrating the SII with the PAS for assessing disease severity and predicting surgical outcomes in pediatric appendicitis, indicating the clinical utility of the combined SII and PAS model in guiding clinical decision-making and optimizing surgical management strategies for pediatric patients with appendicitis.<\/jats:p>","DOI":"10.4240\/wjgs.v16.i8.2565","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T05:25:37Z","timestamp":1723785937000},"page":"2565-2573","source":"Crossref","is-referenced-by-count":15,"title":["Systemic immune-inflammation index combined with pediatric appendicitis score in assessing the severity and prognosis for paediatric appendicitis"],"prefix":"10.4240","volume":"16","author":[{"given":"Li-Ming","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Zhen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.6154"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004785"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/bjs\/znac086"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.10888"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-08129-8"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000003646"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14328"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005018"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06719-3"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20221003"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1055\/s-0040-1710534"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/PEC.0000000000000375"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10637"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-021-06042-2"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1590\/0102-672020220002e1686"},{"key":"B16","unstructured":"Bulanova AA, Akhanzaripov ZA. [Immunotherapy for the treatment of acute appendicitis in children]. Khirurgiia (Mosk) 1994; 34-36"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/s1072-7515(97)00105-1"},{"key":"B18","doi-asserted-by":"crossref","unstructured":"Markar SR, Karthikesalingam A, Falzon A, Kan Y. The diagnostic value of neutrophil: lymphocyte ratio in adults with suspected acute appendicitis. Acta Chir Belg 2010; 110: 543-547","DOI":"10.1080\/00015458.2010.11680673"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000560"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60410-8"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4031"},{"key":"B22","unstructured":"Nana AM, Ouandji CN, Simoens C, Smets D, Mendes da Costa P. Laparoscopic appendectomies: results of a monocentric prospective and non-randomized study. Hepatogastroenterology 2007; 54: 1146-1152"},{"key":"B23","unstructured":"Ko YS, Lin LH, Chen DF. [Laboratory aid and ultrasonography in the diagnosis of appendicitis in children]. Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1995; 36: 415-419"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-023-05168-6"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-021-03844-w"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10203"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000003190"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03855-z"}],"container-title":["World Journal of Gastrointestinal Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v16\/i8\/2565.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v16\/i8\/2565.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T05:26:55Z","timestamp":1723786015000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v16\/i8\/2565.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,27]]},"references-count":28,"journal-issue":{"issue":"8"},"URL":"https:\/\/doi.org\/10.4240\/wjgs.v16.i8.2565","relation":{},"ISSN":["1948-9366"],"issn-type":[{"value":"1948-9366","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8,27]]}}}