{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T04:07:43Z","timestamp":1748578063672,"version":"3.41.0"},"reference-count":24,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Surg"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>In recent years, endoscopic anti-reflux mucosal resection (ARMS) has demonstrated benefits, including good efficacy, ease of operation, low cost, and fewer complications; however, it is still in the exploratory stage.<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To evaluate the clinical efficacy of ARMS in patients with gastroesophageal reflux disease (GERD) and its effects on the gut microbiota.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>This single-center, retrospective, self-controlled study included 80 patients with GERD. All patients underwent endoscopic ARMS and were followed for at least 3 months after surgery. The primary outcome measures were changes in the gut microbiota before and after treatment and clinical efficacy.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>After surgery, the counts of Escherichia coli  and Staphylococcus aureus  were significantly lower than those before surgery (P  &lt; 0.05), whereas the counts of Bifidobacterium  and Lactobacillus  were significantly higher than those before surgery (P  &lt; 0.05). Symptoms, such as reflux and heartburn, were markedly relieved postoperatively. The average Gerd Q score prior to surgery was 11.32 \u00b1 1.26 points, which decreased to 5.89 \u00b1 0.52 points 3 months after surgery. All patients used proton pump inhibitors before surgery, and the proportion of patients using proton pump inhibitors declined significantly postoperatively. Sixteen patients (20.0%) experienced surgery-related adverse reactions within 2 weeks to 1 month post-surgery. The incidence rates of postoperative esophageal stricture and delayed bleeding were 15.0% and 5.0%, respectively.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Endoscopic ARMS can effectively alleviate reflux symptoms, maintain gut microbiota balance, and improve gastrointestinal function in patients with GERD.<\/jats:p>","DOI":"10.4240\/wjgs.v17.i6.103336","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T15:46:21Z","timestamp":1748533581000},"source":"Crossref","is-referenced-by-count":0,"title":["Endoscopic anti-reflux mucosal resection for patients with gastroesophageal reflux disease: Clinical efficacy and impact on gut microbiota"],"prefix":"10.4240","volume":"17","author":[{"given":"Zhe","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Bo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan-Ke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Fei","family":"Pang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-023-02476-3"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s12664-023-01428-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/jgh3.12988"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.5009\/gnl220373"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13611"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms12061110"},{"key":"B7","unstructured":"Inoue H, Ito H, Ikeda H, Sato C, Sato H, Phalanusitthepha C, Hayee B, Eleftheriadis N, Kudo SE. Anti-reflux mucosectomy for gastroesophageal reflux disease in the absence of hiatus hernia: a pilot study. 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