{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:31:33Z","timestamp":1785148293123,"version":"3.55.0"},"reference-count":19,"publisher":"Baishideng Publishing Group Inc.","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Surg"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Esophageal neuroendocrine carcinoma (NEC), a rare and aggressive malignancy with a poor prognosis, is often diagnosed at an advanced stage. The optimal treatment strategy for locally advanced and recurrent esophageal NEC remains unclear, and conversion surgery has only been reported for a few cases. Herein, we present the case of a 66-year-old male with locally advanced esophageal NEC initially diagnosed as squamous cell carcinoma.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>The patient underwent induction chemotherapy with docetaxel, cisplatin, and 5-fluorouracil, followed by conversion surgery, including subtotal esophagectomy, three-field lymph node dissection, and distal pancreatectomy with splenectomy, due to infiltration of the pancreas by the No. 11p lymph node. Postoperative pathological findings revealed a large cell-type NEC without a squamous cell carcinoma component, suspected to be a mixed neuroendocrine\/non-neuroendocrine neoplasm. Hepatic metastasis was diagnosed within one month of surgery. Despite the administration of four courses of irinotecan + cisplatin chemotherapy, the treatment effect was considered a \u2018progressive disease\u2019. After a multidisciplinary discussion, the patient underwent partial liver resection, followed by second-line chemotherapy with amrubicin. The patient achieved three-year survival with no new recurrence.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>This case highlights the potential of multimodal treatment for long-term survival in advanced esophageal NEC.<\/jats:p>","DOI":"10.4240\/wjgs.v17.i6.107086","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T15:46:21Z","timestamp":1748533581000},"source":"Crossref","is-referenced-by-count":2,"title":["Long-term survival with multimodal treatment including conversion surgery for locally advanced esophageal neuroendocrine carcinoma: A case report"],"prefix":"10.4240","volume":"17","author":[{"given":"Kazuya","family":"Okamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentoku","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Kono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Shimoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shusuke","family":"Haruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Takazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harushi","family":"Udagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2019.02.012"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31826d2639"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3167-3"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-7-38"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6389-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173501"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-020-01631-y"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1159\/000443172"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/s44215-024-00155-5"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01827-7"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s10388-016-0551-7"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/his.13975"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.350"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.01.008"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2017.09.1966"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2022.3395"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-015-2706-y"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S201048"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i39.5991"}],"container-title":["World Journal of Gastrointestinal Surgery"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v17\/i6\/107086.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v17\/i6\/107086.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T15:47:34Z","timestamp":1748533654000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-9366\/full\/v17\/i6\/107086.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":19,"journal-issue":{"issue":"6"},"alternative-id":["107086"],"URL":"https:\/\/doi.org\/10.4240\/wjgs.v17.i6.107086","relation":{},"ISSN":["1948-9366"],"issn-type":[{"value":"1948-9366","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,27]]}}}