{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:39:50Z","timestamp":1790642390542,"version":"4.1.0"},"reference-count":49,"publisher":"Europa Digital & Publishing","issue":"R","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["EuroIntervention"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.4244\/eijv9sra24","type":"journal-article","created":{"date-parts":[[2014,10,2]],"date-time":"2014-10-02T14:37:26Z","timestamp":1412260646000},"page":"R140-R148","source":"Crossref","is-referenced-by-count":6,"title":["Restoring autonomic balance: future therapeutic targets"],"prefix":"10.4244","volume":"9","author":[{"given":"Paul A.","family":"Sobotka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Osborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian F.R.","family":"Paton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2774","reference":[{"key":"key-2014730135637-0","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1161\/01.RES.35.2.159","article-title":"A systems analysis approach to understanding long-range arterial blood pressure control and hypertension.","volume":"35","author":"Guyton AC.","year":"1974","journal-title":"Circ Res."},{"key":"key-2014730135637-1","doi-asserted-by":"publisher","first-page":"5975","DOI":"10.1113\/jphysiol.2012.228619","article-title":"A new conceptual paradigm for the hemodynamics of salt-sensitive hypertension: a mathematical modeling approach.","volume":"590","author":"Averina VA.","year":"2012","journal-title":"J Physiol."},{"key":"key-2014730135637-2","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1152\/japplphysiol.00832.2009","article-title":"Pathophysiology of the human sympathetic nervous system in cardiovascular diseases: the transition from mechanisms to medical management.","volume":"108","author":"Esler M.","year":"2010","journal-title":"J Appl Physiol."},{"key":"key-2014730135637-3","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/jhh.2011.66","article-title":"The sympathetic nervous system and blood pressure in humans: implications for hypertension.","volume":"26","author":"Fisher JP.","year":"2012","journal-title":"J Hum Hypertens."},{"key":"key-2014730135637-4","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0306-4522(99)00098-6","article-title":"Reflex response and convergence of pharyngoesophageal and peripheral chemoreceptors in the nucleus of the solitary tract.","volume":"93","author":"Paton JF.","year":"1999","journal-title":"Neuroscience."},{"key":"key-2014730135637-5","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1172\/JCI115221","article-title":"Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans.","volume":"87","author":"Somers VK.","year":"1991","journal-title":"J Clin Invest."},{"key":"key-2014730135637-6","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1161\/HYPERTENSIONAHA.111.182899","article-title":"Sympathetic signatures of cardiovascular disease: a blueprint for development of targeted sympathetic ablation therapies.","volume":"59","author":"Osborn JW.","year":"2012","journal-title":"Hypertension."},{"key":"key-2014730135637-7","first-page":"R863","article-title":"Effects of chronic baroreceptor unloading on blood pressure in the dog.","volume":"288","author":"Thrasher TN.","year":"2005","journal-title":"Am J Physiol."},{"key":"key-2014730135637-8","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1161\/HYPERTENSIONAHA.108.119859","article-title":"Chronic lowering of blood pressure by carotid baroreflex activation: mechanisms and potential for hypertension therapy.","volume":"57","author":"Lohmeier TE.","year":"2011","journal-title":"Hypertension."},{"key":"key-2014730135637-9","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1161\/HYPERTENSIONAHA.109.140665","article-title":"Carotid baroreceptor stimulation, sympathetic activity, baroreflex function, and blood pressure in hypertensive patients.","volume":"55","author":"Heusser K.","year":"2010","journal-title":"Hypertension."},{"key":"key-2014730135637-10","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jash.2012.01.003","article-title":"Baroreflex activation therapy provides durable benefit in patients with resistant hypertension: results of long-term follow-up in the Rheos Pivotal Trial.","volume":"6","author":"Bakris GL.","year":"2012","journal-title":"J Am Soc Hypertens."},{"key":"key-2014730135637-11","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jash.2012.04.004","article-title":"Minimally invasive system for baroreflex activation therapy chronically lowers blood pressure with pacemaker-like safety profile: results from the Barostim neo trial.","volume":"6","author":"Hoppe UC.","year":"2012","journal-title":"J Am Soc Hypertens."},{"key":"key-2014730135637-12","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/S0140-6736(10)62039-9","article-title":"Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial.","volume":"376","author":"Esler MD.","year":"2010","journal-title":"Lancet."},{"key":"key-2014730135637-13","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/S0140-6736(09)60566-3","article-title":"Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study.","volume":"373","author":"Krum H.","year":"2009","journal-title":"Lancet."},{"key":"key-2014730135637-14","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1161\/01.HYP.25.4.878","article-title":"Renal afferent denervation prevents hypertension in rats with chronic renal failure.","volume":"25","author":"Campese VM.","year":"1995","journal-title":"Hypertension."},{"key":"key-2014730135637-15","doi-asserted-by":"publisher","first-page":"1974","DOI":"10.1161\/01.CIR.0000034043.16664.96","article-title":"Sympathetic nerve activity in end-stage renal disease.","volume":"106","author":"Hausberg M.","year":"2002","journal-title":"Circulation."},{"key":"key-2014730135637-16","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1056\/NEJMc0904179","article-title":"Renal sympathetic-nerve ablation for uncontrolled hypertension.","volume":"361","author":"Schlaich MP.","year":"2009","journal-title":"N Engl J Med."},{"key":"key-2014730135637-17","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1161\/HYPERTENSIONAHA.111.00194","article-title":"Substantial reduction in single sympathetic nerve firing after renal denervation in patients with resistant hypertension.","volume":"61","author":"Hering D.","year":"2013","journal-title":"Hypertension."},{"key":"key-2014730135637-18","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1161\/HYPERTENSIONAHA.112.201186","article-title":"Catheter-based renal nerve ablation and centrally generated sympathetic activity in difficult-to-control hypertensive patients: prospective case series.","volume":"60","author":"Brinkmann J.","year":"2012","journal-title":"Hypertension."},{"key":"key-2014730135637-19","doi-asserted-by":"publisher","first-page":"S16","DOI":"10.1038\/jhh.2010.126","article-title":"Renal denervation in resistant hypertension \u2013 a prospective case series.","volume":"26","author":"Chan K.","year":"2012","journal-title":"J Hum Hypertension."},{"key":"key-2014730135637-20","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.4244\/EIJV7I9A171","article-title":"Catheter-based renal denervation for drug-resistant hypertension by using a standard electrophysiology catheter.","volume":"7","author":"Prochnau D.","year":"2012","journal-title":"EuroIntervention."},{"key":"key-2014730135637-21","first-page":"A4439.","article-title":"Catheter-based renal denervation for treatment of resistant hypertension.","volume":"59","author":"Vase H.","year":"2012","journal-title":"Dan Med J."},{"key":"key-2014730135637-22","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1097\/00000658-195310000-00006","article-title":"Total thoracic and partial to total lumbar sympathectomy, splanchnicectomy and celiac ganglionectomy for hypertension.","volume":"138","author":"Grimson KS.","year":"1953","journal-title":"Ann Surg."},{"key":"key-2014730135637-23","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/HYPERTENSIONAHA.111.00474","article-title":"Reversal of genetic salt-sensitive hypertension by targeted sympathetic ablation.","volume":"61","author":"Foss JD.","year":"2013","journal-title":"Hypertension."},{"key":"key-2014730135637-24","first-page":"R934","article-title":"Peripheral vascular resistance and regional blood flows in hypertensive Dahl rats.","volume":"261","author":"Boegehold MA.","year":"1991","journal-title":"Am J Physiol."},{"key":"key-2014730135637-25","first-page":"R1013","article-title":"Regional blood flow in Dahl-Iwai salt-sensitive rats and the effects of dietary L-arginine supplementation.","volume":"272","author":"Tomohiro A.","year":"1997","journal-title":"Am J Physiol."},{"key":"key-2014730135637-26","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0008-6363(98)00077-7","article-title":"Lessons from rat models of hypertension: from Goldblatt to genetic engineering.","volume":"39","author":"Pinto YM.","year":"1998","journal-title":"Cardiovasc Res."},{"key":"key-2014730135637-27","first-page":"211","article-title":"The splanchnic circulation. Primer on the autonomic nervous system.","author":"Fink GD.","year":"2012","journal-title":"Robertson D, Biaggioni I, Burnstock G, Low PA and Paton JFR, Oxford: Academic Press"},{"key":"key-2014730135637-28","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1161\/HYPERTENSIONAHA.107.090696","article-title":"Splanchnic circulation is a critical neural target in angiotensin II salt hypertension in rats.","volume":"50","author":"King AJ.","year":"2007","journal-title":"Hypertension."},{"key":"key-2014730135637-29","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s11906-011-0188-9","article-title":"Neural mechanisms of angiotensin II-salt hypertension: implications for therapies targeting neural control of the splanchinc circulation.","volume":"13","author":"Osborn JW.","year":"2011","journal-title":"Curr Hypertens Rep."},{"key":"key-2014730135637-30","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1161\/01.HYP.0000243799.84573.f8","article-title":"Chronic low-dose angiotensin II infusion increases venomotor tone by neurogenic mechanisms.","volume":"48","author":"King AJ.","year":"2006","journal-title":"Hypertension."},{"key":"key-2014730135637-31","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1113\/expphysiol.2008.046326","article-title":"Region specific changes in sympathetic nerve activity in AngII-salt hypertension.","volume":"95","author":"Osborn JW.","year":"2010","journal-title":"Exp Physiol."},{"key":"key-2014730135637-32","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1161\/HYPERTENSIONAHA.111.169748","article-title":"Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension.","volume":"57","author":"Zubcevic J.","year":"2011","journal-title":"Hypertension."},{"key":"key-2014730135637-33","first-page":"3","article-title":"Vascular analysis of the carotid body in the spontaneously hypertensive rat.","volume":"Chap 1","author":"Clark JA.","year":"1993","journal-title":"In: Neurobiology and Cell Physiology of Chemoreception. Ed: PG Data. Plenum Press"},{"key":"key-2014730135637-34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1113\/jphysiol.1974.sp010484","article-title":"The role of the carotid body chemoreceptors and carotid sinus baroreceptors in the control of cerebral blood vessels.","volume":"237","author":"Ponte J.","year":"1974","journal-title":"J Physiol."},{"key":"key-2014730135637-35","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/0006-8993(93)90871-J","article-title":"Ventrolateral medulla and sympathetic chemoreflex in the rat.","volume":"609","author":"Koshiya N.","year":"1993","journal-title":"Brain Res."},{"key":"key-2014730135637-36","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1113\/jphysiol.2008.154187","article-title":"Increased sympathetic outflow in juvenile rats submitted to chronic intermittent hypoxia correlates with enhanced expiratory activity.","volume":"586","author":"Zoccal DB.","year":"2008","journal-title":"J Physiol."},{"key":"key-2014730135637-37","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1152\/jappl.1992.72.5.1978","article-title":"Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea.","volume":"72","author":"Fletcher EC.","year":"1992","journal-title":"J Appl Physiol."},{"key":"key-2014730135637-38","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1161\/CIRCRESAHA.109.206946","article-title":"Chemoreceptor hypersensitivity, sympathetic excitation, and overexpression of ASIC and TASK channels before the onset of hypertension in SHR.","volume":"106","author":"Tan ZY.","year":"2010","journal-title":"Circ Res."},{"key":"key-2014730135637-39","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1161\/01.HYP.11.6.608","article-title":"Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects.","volume":"11","author":"Somers VK.","year":"1988","journal-title":"Hypertension."},{"key":"key-2014730135637-40","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/cvr\/16.3.163","article-title":"Increased sensitivity of the arterial chemoreceptor drive in young men with mild hypertension.","volume":"16","author":"Trzebski A.","year":"1982","journal-title":"Cardiovasc Res."},{"key":"key-2014730135637-41","doi-asserted-by":"publisher","first-page":"4269","DOI":"10.1113\/jphysiol.2012.237800","article-title":"Hypertension is critically dependent on the carotid body input in the spontaneously hypertensive rat.","volume":"590","author":"Abdala AP.","year":"2012","journal-title":"J Physiol."},{"key":"key-2014730135637-42","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/hr.2011.209","article-title":"Tonic activity of carotid body chemoreceptors contributes to the increased sympathetic drive in essential hypertension.","volume":"35","author":"Siski M.","year":"2012","journal-title":"Hypertens Res."},{"key":"key-2014730135637-43","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1097\/HJH.0b013e328350136c","article-title":"Peripheral chemoreflex activation contributes to sympathetic baroreflex impairment in chronic heart failure.","volume":"30","author":"Despas F.","year":"2012","journal-title":"J Hypertension."},{"key":"key-2014730135637-44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1161\/HYPERTENSIONAHA.111.00064","article-title":"The carotid body as a therapeutic target for treatment of sympathetically mediated diseases.","volume":"61","author":"Paton JF.","year":"2013","journal-title":"Hypertension."},{"key":"key-2014730135637-45","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1161\/01.CIR.99.9.1183","article-title":"Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea.","volume":"99","author":"Narkiewicz K.","year":"1999","journal-title":"Circulation."},{"key":"key-2014730135637-46","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1139\/y03-056","article-title":"The essential role of carotid body chemoreceptors in sleep apnea.","volume":"81","author":"Smith CA.","year":"2003","journal-title":"Can J Physiol Pharmacol."},{"key":"key-2014730135637-47","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1378\/chest.40.6.595","article-title":"Surgical removal of the carotid body for bronchial asthma.","volume":"40","author":"Nakayama K.","year":"1961","journal-title":"Dis Chest."},{"key":"key-2014730135637-48","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1212\/WNL.0b013e3182088108","article-title":"Deep brain stimulation relieves refractory hypertension.","volume":"76","author":"Patel NK.","year":"2012","journal-title":"Neurology."}],"container-title":["EuroIntervention"],"original-title":[],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T19:38:12Z","timestamp":1565897892000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.pcronline.com\/eurointervention\/R_issue\/24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":49,"journal-issue":{"issue":"R","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["EIJV9SRA24"],"URL":"https:\/\/doi.org\/10.4244\/eijv9sra24","relation":{},"ISSN":["1774-024X"],"issn-type":[{"value":"1774-024X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}