{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T05:04:08Z","timestamp":1731128648396,"version":"3.28.0"},"reference-count":21,"publisher":"Baishideng Publishing Group Inc.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Oncol"],"abstract":"<jats:p>Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) are rare mixed tumors containing both neuroendocrine and non-neuroendocrine components that occupy at least 30% of the whole tumor. Biologically, both components appear to derive from an identical cellular precursor undergoing early dual differentiation or late transdifferentiation. While our understanding of MiNENs has improved in recent years, many areas of uncertainty remain. In this context, setting diagnostic criteria capable of capturing the continuum of disease biology while providing clinically meaningful information in terms of prognosis and response to treatments appears vital to advance the field and improve patients\u2019 outcomes. Evidence is needed to generate robust classification schemes, and multi-institutional cooperation will likely play a crucial role in building adequately powered cohorts to address some of the most pressing questions discussed in this Editorial. What is the minimum representation for each component needed to define MiNENs? How can the epidemiology of MiNENs change according to different diagnostic definitions? How can we generate the clinical evidence needed to optimize the management of MiNENs?<\/jats:p>","DOI":"10.4251\/wjgo.v16.i12.4532","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T06:17:27Z","timestamp":1731046647000},"page":"4532-4536","source":"Crossref","is-referenced-by-count":1,"title":["Mixed neuroendocrine non-neuroendocrine tumors: The quest for evidence"],"prefix":"10.4251","volume":"16","author":[{"given":"Mauro","family":"Cives","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camillo","family":"Porta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Palmirotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v16.i4.1166"},{"key":"B2","unstructured":"WHO Classification of Tumours Editorial Board.   WHO classification of endocrine and neuroendocrine tumours. Available from: https:\/\/tumourclassification.iarc.who.int\/welcome\/"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-016-9432-9"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.08.004"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198700111-00007"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1159\/000475527"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-021-09676-z"},{"key":"B8","unstructured":"WHO classification of tumors Editorial Board.   Thoracic Tumours WHO Classification of Tumours, 5th ed. 2021"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-0579-z"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18678"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.220"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0815-3"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.14180"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-14-0410"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3182093657"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-17-0557"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1159\/000508376"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13249"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21493"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2021.04.016"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-022-00109-y"}],"container-title":["World Journal of Gastrointestinal Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i12\/4532.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i12\/4532.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T06:17:31Z","timestamp":1731046651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i12\/4532.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,15]]},"references-count":21,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.4251\/wjgo.v16.i12.4532","relation":{},"ISSN":["1948-5204"],"issn-type":[{"value":"1948-5204","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,15]]}}}