{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T00:30:50Z","timestamp":1706920250569},"reference-count":17,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Oncol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer (CRC). Effective drainage is often impossible before initiating systemic chemotherapy, owing to the liver\u2019s diffuse metastatic involvement. Moreover, an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently unavailable.<\/jats:p>\n          <jats:p>CASE SUMMARY<\/jats:p>\n          <jats:p>The patient, a man in his 50s, presented with progressive fatigue and severe jaundice. Computed tomography revealed multiple hepatic masses with thickened walls in the sigmoid colon, which was pathologically confirmed as a well-differentiated adenocarcinoma. No RAS  or BRAF  mutations were detected. The Eastern Cooperative Oncology Group (ECOG) performance status (PS) score was 2. Biliary drainage was impossible due to the absence of a dilated bile duct, and panitumumab monotherapy was promptly initiated. Subsequently, the bilirubin level decreased and then normalized, and the patient\u2019s PS improved to zero ECOG score after four cycles of therapy without significant adverse events.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS  wild-type CRC and hepatic metastases with severe hyperbilirubinemia.<\/jats:p>","DOI":"10.4251\/wjgo.v16.i2.557","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T07:16:05Z","timestamp":1706858165000},"page":"557-562","source":"Crossref","is-referenced-by-count":0,"title":["Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report"],"prefix":"10.4251","volume":"16","author":[{"given":"Toshiaki","family":"Tsurui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Hirasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaro","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Tsunoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00044-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22272"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2005.11.002"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2385"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2014.0016"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.03.123"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2147\/tcrm.s3951"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1177\/1758834016637585"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/420159"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1159\/000358799"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2008.170"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.10.007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx175"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.309"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/ONCO.13523"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyp161"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx621.046"}],"container-title":["World Journal of Gastrointestinal Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i2\/557.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i2\/557.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T08:26:41Z","timestamp":1706862401000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i2\/557.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,15]]},"references-count":17,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4251\/wjgo.v16.i2.557","relation":{},"ISSN":["1948-5204"],"issn-type":[{"value":"1948-5204","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2,15]]}}}