{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:41:28Z","timestamp":1769514088128,"version":"3.49.0"},"reference-count":39,"publisher":"Baishideng Publishing Group Inc.","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Oncol"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n          <jats:p>There is scant literature on hepatocellular carcinoma (HCC) in patients with Budd-Chiari syndrome (BCS).<\/jats:p>\n          <jats:p>AIM<\/jats:p>\n          <jats:p>To assess the magnitude, clinical characteristics, feasibility, and outcomes of treatment in BCS-HCC.<\/jats:p>\n          <jats:p>METHODS<\/jats:p>\n          <jats:p>A total of 904 BCS patients from New Delhi, India and 1140 from Mumbai, India were included. The prevalence and incidence of HCC were determined, and among patients with BCS-HCC, the viability and outcomes of interventional therapy were evaluated.<\/jats:p>\n          <jats:p>RESULTS<\/jats:p>\n          <jats:p>In the New Delhi cohort of 35 BCS-HCC patients, 18 had HCC at index presentation (prevalence 1.99%), and 17 developed HCC over a follow-up of 4601 person-years, [incidence 0.36 (0.22-0.57) per 100 person-years]. BCS-HCC patients were older when compared to patients with BCS alone (P  = 0.001) and had a higher proportion of inferior vena cava block, cirrhosis, and long-segment vascular obstruction. The median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up (13029 ng\/mL vs  500 ng\/mL, P  = 0.01). Of the 35 BCS-HCC, 26 (74.3%) underwent radiological interventions for BCS, and 22 (62.8%) patients underwent treatment for HCC [transarterial chemoembolization in 18 (81.8%), oral tyrosine kinase inhibitor in 3 (13.6%), and transarterial radioembolization in 1 (4.5%)]. The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs  3.1 mo (P  = 0.0001). In contrast to the New Delhi cohort, the Mumbai cohort of BCS-HCC patients were predominantly males, presented with a more advanced HCC [Barcelona Clinic Liver Cancer C and D], and 2 patients underwent liver transplantation.<\/jats:p>\n          <jats:p>CONCLUSION<\/jats:p>\n          <jats:p>HCC is not uncommon in patients with BCS. Radiological interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.<\/jats:p>","DOI":"10.4251\/wjgo.v16.i3.699","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T02:02:20Z","timestamp":1710208940000},"page":"699-715","source":"Crossref","is-referenced-by-count":7,"title":["Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome"],"prefix":"10.4251","volume":"16","author":[{"given":"Ankit","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sagnik","family":"Biswas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shekhar","family":"Swaroop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnav","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayush","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gautam","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anshuman","family":"Elhence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Vaidya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Gupte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Mohanka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwani Kumar","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivanand","family":"Gamanagatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashi Bala","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subrat Kumar","family":"Acharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shalimar","family":"Shalimar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510280505"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9232-1_9"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32835eb8d4"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.139477"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i16.1946"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-13-105"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1075685"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13219"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13173"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.11.018"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.09090738"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.202.1.8988182"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(01)00130-1"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.03.019"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvir.2020.08.035"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13604"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1002\/Lt.20034"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1247132"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03642.x"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9232-1_18"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2006.04611.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-017-9810-5"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200403000-00012"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199807000-00014"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.278"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1159\/000508568"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00240-3"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(00)00053-2"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00443.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(02)08649-x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1177\/000331976801900805"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.138.119"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(82)90001-4"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-198503000-00005"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840090121"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1996.tb00056.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199401000-00003"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02303.x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-009-9122-5"}],"container-title":["World Journal of Gastrointestinal Oncology"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i3\/699.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i3\/699.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T02:03:29Z","timestamp":1710209009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-5204\/full\/v16\/i3\/699.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,15]]},"references-count":39,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4251\/wjgo.v16.i3.699","relation":{},"ISSN":["1948-5204"],"issn-type":[{"value":"1948-5204","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,15]]}}}