{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:33:05Z","timestamp":1715128385357},"reference-count":39,"publisher":"Baishideng Publishing Group Inc.","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Oncol"],"abstract":"BACKGROUND<\/jats:p>\n Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular diseases. Among which, ventricular arrhythmia is a prevalent clinical concern. This suggests that ventricular arrhythmias may have predictive value in the prognosis of patients with gastrointestinal tumors.<\/jats:p>\n AIM<\/jats:p>\n To explore the prognostic value of ventricular arrhythmias in patients with gastrointestinal tumors receiving surgery.<\/jats:p>\n METHODS<\/jats:p>\n We retrospectively analyzed data from 130 patients undergoing gastrointestinal tumor resection. These patients were evaluated by a 24-h ambulatory electrocardiogram (ECG) at the Sixth Affiliated Hospital of Sun Yat-sen University from January 2018 to June 2020. Additionally, 41 general healthy age-matched and sex-matched controls were included. Patients were categorized into survival and non-survival groups. The primary endpoint was all-cause mortality, and secondary endpoints included major adverse cardiovascular events (MACEs).<\/jats:p>\n RESULTS<\/jats:p>\n Colorectal tumors comprised 90% of cases. Preoperative ambulatory ECG monitoring revealed that among the 130 patients with gastrointestinal tumors, 100 (76.92%) exhibited varying degrees of premature ventricular contractions (PVCs). Ten patients (7.69%) manifested non-sustained ventricular tachycardia (NSVT). The patients with gastrointestinal tumors exhibited higher PVCs compared to the healthy controls on both conventional ECG [27 (21.3) vs 1 (2.5), P = 0.012] and 24-h ambulatory ECG [14 (1.0, 405) vs 1 (0, 6.5), P < 0.001]. Non-survivors had a higher PVC count than survivors [150.50 (7.25, 1690.50) vs 9 (0, 229.25), P = 0.020]. During the follow-up period, 24 patients died and 11 patients experienced MACEs. Univariate analysis linked PVC > 35\/24 h to all-cause mortality, and NSVT was associated with MACE. However, neither PVC burden nor NSVT independently predicted outcomes according to multivariate analysis.<\/jats:p>\n CONCLUSION<\/jats:p>\n Patients with gastrointestinal tumors exhibited elevated PVCs. PVCs > 35\/24 h and NSVT detected by 24-h ambulatory ECG were prognostically significant but were not found to be independent predictors.<\/jats:p>","DOI":"10.4251\/wjgo.v16.i5.1787","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T16:41:23Z","timestamp":1715100083000},"page":"1787-1795","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic relevance of ventricular arrhythmias in surgical patients with gastrointestinal tumors"],"prefix":"10.4251","volume":"16","author":[{"given":"Jiao-Jie","family":"Xue","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Tian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong-Chong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Chong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi-Yao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Qi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Jing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Jie","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2024,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101174"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.19.2517"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2018.04.030"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1502824"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100794"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.02.065"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-018-01382-x"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.948"},{"key":"B9","unstructured":"Raftery EB, Cashman PM. 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