{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T20:08:56Z","timestamp":1793909336434,"version":"4.8.0"},"reference-count":45,"publisher":"Baishideng Publishing Group Inc.","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Gastrointest Oncol"],"abstract":"BACKGROUND<\/jats:p>\n Gastric intestinal metaplasia (GIM) represents a critical precancerous condition in the progression from chronic gastritis to gastric cancer, with limited therapeutic options. Emerging evidence suggests that taurine, a cytoprotective amino acid, may modulate gastric epithelial dysfunction. However, its application and efficiency in the context of GIM remain poorly understood.<\/jats:p>\n AIM<\/jats:p>\n To investigate the therapeutic effects of taurine on GIM using patient-derived organoids and Atp4a -\/- mouse models.<\/jats:p>\n METHODS<\/jats:p>\n Patient-derived GIM organoids (n = 3) and Atp4a -\/- mice, which spontaneously develop GIM, were used as experimental models. Morphological changes were assessed via Alcian blue-periodic acid Schiff staining. The expression levels of the gastric epithelial marker mucin 5AC (MUC5AC ) and GIM-associated markers (caudal type homeobox 2 [CDX2 ], MUC2 , Trefoil factor family 3 [TFF3 ]) were quantified via quantitative PCR, Western blotting, and immunohistochemistry.<\/jats:p>\n RESULTS<\/jats:p>\n We confirmed that taurine treatment significantly attenuated pathological changes, including glandular hypertrophy and vacuolar dilation, in Atp4a -\/- mice. It also reduced GIM severity compared with that in the untreated model group. Under taurine treatment, MUC5AC expression was significantly increased, whereas the intestinal-specific markers CDX2 , MUC2 , and TFF3 were reduced (P < 0.05). In parallel, in patient-derived GIM organoids, taurine treatment significantly ameliorated GIM features, as evidenced by increased MUC5AC expression and decreased CDX2 , MUC2 , and TFF3 expression.<\/jats:p>\n CONCLUSION<\/jats:p>\n This study highlights the potential application of taurine as a therapeutic agent for treating GIM, offering a promising strategy for its clinical management.<\/jats:p>","DOI":"10.4251\/wjgo.v18.i2.114161","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T07:15:38Z","timestamp":1770016538000},"source":"Crossref","is-referenced-by-count":3,"title":["Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and\n Atp4a<\/i>\n -\/-<\/sup>\n mice"],"prefix":"10.4251","volume":"18","author":[{"given":"Ke","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fa-Zhan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Yuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i3.1311"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-024-02633-x"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12507"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq370"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.028"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210251"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.83a.15050"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101223"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/science.adi3025"},{"key":"B10","unstructured":"Louren\u00e7o R, Camilo ME. 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