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Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-238.","DOI":"10.1056\/NEJM200007273430401"},{"key":"ref2","doi-asserted-by":"crossref","unstructured":"Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Yamada Y, Fukuda K, Tsukiyama K, Suzuki H. Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet 2005;365:1642-1644.","DOI":"10.1016\/S0140-6736(05)66383-0"},{"key":"ref3","doi-asserted-by":"crossref","unstructured":"Noguchi H, Iwanaga Y, Okitsu T, Nagata H, Yonekawa Y, Matsumoto S. Evaluation of islet transplantation from non-heart beating donors. Am J Transplant 2006;6:2476-2482.","DOI":"10.1111\/j.1600-6143.2006.01499.x"},{"key":"ref4","doi-asserted-by":"crossref","unstructured":"Froud T, Ricordi C, Baidal DA, Hafiz MM, Ponte G, Cure P, Pileggi A, Poggioli R, Ichii H, Khan A. Islet transplantation in type 1 diabetes mellitus using cultured islets and steroid-free immunosuppression: Miami experience. Am J Transplant 2005;5:2037-2046.","DOI":"10.1111\/j.1600-6143.2005.00957.x"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Hering BJ, Kandaswamy R, Ansite JD, Eckman PM, Nakano M, Sawada T, Matsumoto I, Ihm SH, Zhang HJ, Parkey J. Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 2005;293:830-835.","DOI":"10.1001\/jama.293.7.830"},{"key":"ref6","doi-asserted-by":"crossref","unstructured":"Robertson RP. Islet transplantation as a treatment for diabetes - a work in progress. N Engl J Med 2004;350:694-705.","DOI":"10.1056\/NEJMra032425"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Edlund H. Pancreatic organogenesis--developmental mechanisms and implications for therapy. Nat Rev Genet 2002;3:524-532.","DOI":"10.1038\/nrg841"},{"key":"ref8","doi-asserted-by":"crossref","unstructured":"Zaret KS, Grompe M. Generation and regeneration of cells of the liver and pancreas. Science 2008;322:1490-1494.","DOI":"10.1126\/science.1161431"},{"key":"ref9","doi-asserted-by":"crossref","unstructured":"Zaret KS. Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation. Nat Rev Genet 2008;9:329-340.","DOI":"10.1038\/nrg2318"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"McLin VA, Rankin SA, Zorn AM. Repression of Wnt\/beta-catenin signaling in the anterior endoderm is essential for liver and pancreas development. Development 2007;134:2207-2217.","DOI":"10.1242\/dev.001230"},{"key":"ref11","doi-asserted-by":"crossref","unstructured":"Wells JM, Melton DA. Early mouse endoderm is patterned by soluble factors from adjacent germ layers. Development 2000;127:1563-1572.","DOI":"10.1242\/dev.127.8.1563"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Chen Y, Pan FC, Brandes N, Afelik S, Sölter M, Pieler T. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol 2004;271:144-160.","DOI":"10.1016\/j.ydbio.2004.03.030"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Kumar M, Jordan N, Melton D, Grapin-Botton A. Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate. Dev Biol 2003;259:109-122.","DOI":"10.1016\/S0012-1606(03)00183-0"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Martín M, Gallego-Llamas J, Ribes V, Kedinger M, Niederreither K, Chambon P, Dollé P, Gradwohl G. Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol 2005;284:399-411.","DOI":"10.1016\/j.ydbio.2005.05.035"},{"key":"ref15","doi-asserted-by":"crossref","unstructured":"Stafford D, White RJ, Kinkel MD, Linville A, Schilling TF, Prince VE. Retinoids signal directly to zebrafish endoderm to specify insulin-expressing beta-cells. Development 2006;133:949-956.","DOI":"10.1242\/dev.02263"},{"key":"ref16","doi-asserted-by":"crossref","unstructured":"Deutsch G, Jung J, Zheng M, Lóra J, Zaret KS. A bipotential precursor population for pancreas and liver within the embryonic endoderm. Development 2001;128:871-881.","DOI":"10.1242\/dev.128.6.871"},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Jung J, Zheng M, Goldfarb M, Zaret KS. Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 1999;284:1998-2003.","DOI":"10.1126\/science.284.5422.1998"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Rossi JM, Dunn NR, Hogan BL, Zaret KS. Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev 2001;15:1998-2009.","DOI":"10.1101\/gad.904601"},{"key":"ref19","doi-asserted-by":"crossref","unstructured":"Shin D, Shin CH, Tucker J, Ober EA, Rentzsch F, Poss KD, Hammerschmidt M, Mullins MC, Stainier DY. Bmp and Fgf signaling are essential for liver specification in zebrafish. Development 2007;134:2041-2050.","DOI":"10.1242\/dev.000281"},{"key":"ref20","doi-asserted-by":"crossref","unstructured":"Apelqvist A, Ahlgren U, Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 1997;7:801-804.","DOI":"10.1016\/S0960-9822(06)00340-X"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 1998;12:1705-1713.","DOI":"10.1101\/gad.12.11.1705"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002;129:2447-2457.","DOI":"10.1242\/dev.129.10.2447"},{"key":"ref23","doi-asserted-by":"crossref","unstructured":"Kawaguchi Y, Cooper B, Gannon M, Ray M, MacDonald RJ, Wright CV. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet 2002;32:128-134.","DOI":"10.1038\/ng959"},{"key":"ref24","doi-asserted-by":"crossref","unstructured":"Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994;371:606-609.","DOI":"10.1038\/371606a0"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Offield MF, Jetton TL, Labosky PA, Ray M, Stein RW, Magnuson MA, Hogan BL, Wright CV. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996;122:983-995.","DOI":"10.1242\/dev.122.3.983"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Fujitani Y, Fujitani S, Boyer DF, Gannon M, Kawaguchi Y, Ray M, Shiota M, Stein RW, Magnuson MA, Wright CV. Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation. Genes Dev 2006;20:253-266.","DOI":"10.1101\/gad.1360106"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U, Edlund H. Notch signalling controls pancreatic cell differentiation. Nature 1999;400:877-881.","DOI":"10.1038\/23716"},{"key":"ref28","doi-asserted-by":"crossref","unstructured":"Jensen J, Pedersen EE, Galante P, Hald J, Heller RS, Ishibashi M, Kageyama R, Guillemot F, Serup P, Madsen OD. Control of endodermal endocrine development by Hes-1. Nat Genet 2000;24:36-44.","DOI":"10.1038\/71657"},{"key":"ref29","doi-asserted-by":"crossref","unstructured":"Nakhai H, Siveke JT, Klein B, Mendoza-Torres L, Mazur PK, Algül H, Radtke F, Strobl L, Zimber-Strobl U, Schmid RM. Conditional ablation of Notch signaling in pancreatic development. Development 2008;135:2757-2765.","DOI":"10.1242\/dev.013722"},{"key":"ref30","doi-asserted-by":"crossref","unstructured":"Gradwohl G, Dierich A, LeMeur M, Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 2000;97:1607-1611.","DOI":"10.1073\/pnas.97.4.1607"},{"key":"ref31","doi-asserted-by":"crossref","unstructured":"Huang HP, Liu M, El-Hodiri HM, Chu K, Jamrich M, Tsai MJ. Regulation of the pancreatic islet-specific gene BETA2 (neuroD) by neurogenin 3. Mol Cell Biol 2000;20:3292-3307.","DOI":"10.1128\/MCB.20.9.3292-3307.2000"},{"key":"ref32","doi-asserted-by":"crossref","unstructured":"Naya FJ, Huang HP, Qiu Y, Mutoh H, DeMayo FJ, Leiter AB, Tsai MJ. Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2\/neuroD-deficient mice. Genes Dev 1997;11:2323-2334.","DOI":"10.1101\/gad.11.18.2323"},{"key":"ref33","doi-asserted-by":"crossref","unstructured":"Matsuoka TA, Zhao L, Artner I, Jarrett HW, Friedman D, Means A, Stein R. Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells. Mol Cell Biol 2003;23:6049-6062.","DOI":"10.1128\/MCB.23.17.6049-6062.2003"},{"key":"ref34","doi-asserted-by":"crossref","unstructured":"Olbrot M, Rud J, Moss LG, Sharma A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci USA 2002;99:6737-6742.","DOI":"10.1073\/pnas.102168499"},{"key":"ref35","doi-asserted-by":"crossref","unstructured":"Hoffman LM, Carpenter MK. Characterization and culture of human embryonic stem cells. Nat Biotechnol 2005;23:699-708.","DOI":"10.1038\/nbt1102"},{"key":"ref36","doi-asserted-by":"crossref","unstructured":"Soto-Gutiérrez A, Kobayashi N, Rivas-Carrillo JD, Navarro-Alvarez N, Zhao D, Okitsu T, Noguchi H, Basma H, Tabata Y, Chen Y. Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell-derived hepatocytes. Nat Biotechnol 2006;24:1412-1419.","DOI":"10.1038\/nbt1257"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Soria B, Roche E, Berná G, León-Quinto T, Reig JA, Martín F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000;49:157-162.","DOI":"10.2337\/diabetes.49.2.157"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Assady S, Maor G, Amit M, Itskovitz-Eldor J, Skorecki KL, Tzukerman M. Insulin production by human embryonic stem cells. Diabetes 2001;50:1691-1697.","DOI":"10.2337\/diabetes.50.8.1691"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001;292:1389-1394.","DOI":"10.1126\/science.1058866"},{"key":"ref40","doi-asserted-by":"crossref","unstructured":"Moritoh Y, Yamato E, Yasui Y, Miyazaki S, Miyazaki J. Analysis of insulin-producing cells during in vitro differentiation from feeder-free embryonic stem cells. Diabetes 2003;52:1163-1168.","DOI":"10.2337\/diabetes.52.5.1163"},{"key":"ref41","doi-asserted-by":"crossref","unstructured":"Lester LB, Kuo HC, Andrews L, Nauert B, Wolf DP. Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes. Reprod Biol Endocrinol 2004;2:42.","DOI":"10.1186\/1477-7827-2-42"},{"key":"ref42","doi-asserted-by":"crossref","unstructured":"Segev H, Fishman B, Ziskind A, Shulman M, Itskovitz-Eldor J. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 2004;22:265-274.","DOI":"10.1634\/stemcells.22-3-265"},{"key":"ref43","doi-asserted-by":"crossref","unstructured":"D'Amour KA, Agulnick AD, Eliazer S, Kelly OG, Kroon E, Baetge EE. Efficient differentiation of human embryonic stem cells to definitive endoderm. Nat Biotechnol 2005;23:1534-1541.","DOI":"10.1038\/nbt1163"},{"key":"ref44","doi-asserted-by":"crossref","unstructured":"Yamaguchi TP. Heads or tails: Wnts and anterior-posterior patterning. Curr Biol 2001;11:R713-R724.","DOI":"10.1016\/S0960-9822(01)00417-1"},{"key":"ref45","doi-asserted-by":"crossref","unstructured":"D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006;24:1392-1401.","DOI":"10.1038\/nbt1259"},{"key":"ref46","doi-asserted-by":"crossref","unstructured":"Kroon E, Martinson LA, Kadoya K, Bang AG, Kelly OG, Eliazer S, Young H, Richardson M, Smart NG, Cunningham J. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008;26:443-452.","DOI":"10.1038\/nbt1393"},{"key":"ref47","doi-asserted-by":"crossref","unstructured":"Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 2009;4:348-358.","DOI":"10.1016\/j.stem.2009.01.014"},{"key":"ref48","doi-asserted-by":"crossref","unstructured":"Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"ref49","doi-asserted-by":"crossref","unstructured":"Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007;131:861-872.","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"ref50","doi-asserted-by":"crossref","unstructured":"Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007;318:1917-1920.","DOI":"10.1126\/science.1151526"},{"key":"ref51","doi-asserted-by":"crossref","unstructured":"Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells. Nature 2007;448:313-317.","DOI":"10.1038\/nature05934"},{"key":"ref52","doi-asserted-by":"crossref","unstructured":"Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol 2008;26:1269-1275.","DOI":"10.1038\/nbt.1502"},{"key":"ref53","doi-asserted-by":"crossref","unstructured":"Kim JB, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, Araúzo-Bravo MJ, Ruau D, Han DW, Zenke M. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 2008;454:646-650.","DOI":"10.1038\/nature07061"},{"key":"ref54","doi-asserted-by":"crossref","unstructured":"Kim JB, Sebastiano V, Wu G, Araúzo-Bravo MJ, Sasse P, Gentile L, Ko K, Ruau D, Ehrich M, van den Boom D. Oct4-induced pluripotency in adult neural stem cells. Cell 2009;136:411-419.","DOI":"10.1016\/j.cell.2009.01.023"},{"key":"ref55","doi-asserted-by":"crossref","unstructured":"Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008;322:949-953.","DOI":"10.1126\/science.1164270"},{"key":"ref56","doi-asserted-by":"crossref","unstructured":"Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. Induced pluripotent stem cells generated without viral integration. Science 2008;322:945-949.","DOI":"10.1126\/science.1162494"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Zhou H, Wu S, Joo JY, Zhu S, Han DW, Lin T, Trauger S, Bien G, Yao S, Zhu Y. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 2009;4:381-384.","DOI":"10.1016\/j.stem.2009.04.005"},{"key":"ref58","doi-asserted-by":"crossref","unstructured":"Noguchi H, Matsumoto S. Protein transduction technology offers a novel therapeutic approach for diabetes. J Hepatobiliary Pancreat Surg 2006;13:306-313.","DOI":"10.1007\/s00534-005-1038-4"},{"key":"ref59","unstructured":"Noguchi H, Matsumoto S. Protein transduction technology: a novel therapeutic perspective. Acta Med Okayama 2006;60:1-11."},{"key":"ref60","doi-asserted-by":"crossref","unstructured":"Noguchi H, Matsumoto S, Onaca N, Naziruddin B, Jackson A, Ikemoto T, Shimoda M, Fujita Y, Chujo D, Iwanaga Y. Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function. Hum Gene Ther 2009;20:73-85.","DOI":"10.1089\/hum.2008.125"},{"key":"ref61","doi-asserted-by":"crossref","unstructured":"Noguchi H, Nakai Y, Ueda M, Masui Y, Futaki S, Kobayashi N, Hayashi S, Matsumoto S. Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor. Diabetologia 2007;50:612-619.","DOI":"10.1007\/s00125-006-0563-2"},{"key":"ref62","doi-asserted-by":"crossref","unstructured":"Tateishi K, He J, Taranova O, Liang G, D'Alessio AC, Zhang Y. Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J Biol Chem 2008;283:31601-31607.","DOI":"10.1074\/jbc.M806597200"},{"key":"ref63","doi-asserted-by":"crossref","unstructured":"Zhang D, Jiang W, Liu M, Sui X, Yin X, Chen S, Shi Y, Deng H. Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res 2009;19:429-438.","DOI":"10.1038\/cr.2009.28"},{"key":"ref64","doi-asserted-by":"crossref","unstructured":"Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proc Natl Acad Sci USA 2009;106:15768-15773.","DOI":"10.1073\/pnas.0906894106"},{"key":"ref65","doi-asserted-by":"crossref","unstructured":"Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004;429:41-46.","DOI":"10.1038\/nature02520"},{"key":"ref66","doi-asserted-by":"crossref","unstructured":"Teta M, Rankin MM, Long SY, Stein GM, Kushner JA. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 2007;12:817-826.","DOI":"10.1016\/j.devcel.2007.04.011"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Noguchi H, Kaneto H, Weir GC, Bonner-Weir S. PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes 2003;52:1732-1737.","DOI":"10.2337\/diabetes.52.7.1732"},{"key":"ref68","doi-asserted-by":"crossref","unstructured":"Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJ. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci USA 2000;97:7999-8004.","DOI":"10.1073\/pnas.97.14.7999"},{"key":"ref69","doi-asserted-by":"crossref","unstructured":"Heremans Y, Van De Casteele M, in't Veld P, Gradwohl G, Serup P, Madsen O, Pipeleers D, Heimberg H. Recapitulation of embryonic neuroendocrine differentiation in adult human pancreatic duct cells expressing neurogenin 3. J Cell Biol 2002;159:303-312.","DOI":"10.1083\/jcb.200203074"},{"key":"ref70","doi-asserted-by":"crossref","unstructured":"Suzuki A, Nakauchi H, Taniguchi H. Prospective isolation of multipotent pancreatic progenitors using flow-cytometric cell sorting. Diabetes 2004;53:2143-2152.","DOI":"10.2337\/diabetes.53.8.2143"},{"key":"ref71","doi-asserted-by":"crossref","unstructured":"Oshima Y, Suzuki A, Kawashimo K, Ishikawa M, Ohkohchi N, Taniguchi H. Isolation of mouse pancreatic ductal progenitor cells expressing CD133 and c-Met by flow cytometric cell sorting. Gastroenterology 2007;132:720-732.","DOI":"10.1053\/j.gastro.2006.11.027"},{"key":"ref72","doi-asserted-by":"crossref","unstructured":"Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008;132:197-207.","DOI":"10.1016\/j.cell.2007.12.015"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Street CN, Lakey JR, Shapiro AM, Imes S, Rajotte RV, Ryan EA, Lyon JG, Kin T, Avila J, Tsujimura T. Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome. Diabetes 2004;53:3107-3114.","DOI":"10.2337\/diabetes.53.12.3107"},{"key":"ref74","doi-asserted-by":"crossref","unstructured":"Gu G, Brown JR, Melton DA. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev 2003;120:35-43.","DOI":"10.1016\/S0925-4773(02)00330-1"},{"key":"ref75","doi-asserted-by":"crossref","unstructured":"Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, Morita R, Sharma A, Bonner-Weir S. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci USA 2008;105:19915-19919.","DOI":"10.1073\/pnas.0805803105"},{"key":"ref76","doi-asserted-by":"crossref","unstructured":"Yamamoto T, Yamato E, Taniguchi H, Shimoda M, Tashiro F, Hosoi M, Sato T, Fujii S, Miyazaki JI. Stimulation of cAMP signalling allows isolation of clonal pancreatic precursor cells from adult mouse pancreas. Diabetologia 2006;49:2359-2367.","DOI":"10.1007\/s00125-006-0372-7"},{"key":"ref77","doi-asserted-by":"crossref","unstructured":"Noguchi H, Oishi K, Ueda M, Yukawa H, Hayashi S, Kobayashi N, Levy MF, Matusmoto S. Establishment of mouse pancreatic stem cell line. Cell Transplant 2009;18:563-571.","DOI":"10.1177\/096368970901805-612"},{"key":"ref78","doi-asserted-by":"crossref","unstructured":"Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D, Takita M, Kobayashi N, Onaca N. Characterization of human pancreatic progenitor cells. Cell Transplant 2010;In press.","DOI":"10.3727\/096368910X509004"},{"key":"ref79","doi-asserted-by":"crossref","unstructured":"Nishio J, Gaglia JL, Turvey SE, Campbell C, Benoist C, Mathis D. Islet recovery and reversal of murine type 1 diabetes in the absence of any infused spleen cell contribution. Science 2006;311:1775-1778.","DOI":"10.1126\/science.1124004"},{"key":"ref80","doi-asserted-by":"crossref","unstructured":"Lardon J, Huyens N, Rooman I, Bouwens L. Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas. Virchows Arch 2004;444:61-65.","DOI":"10.1007\/s00428-003-0930-z"},{"key":"ref81","doi-asserted-by":"crossref","unstructured":"Baeyens L, De Breuck S, Lardon J, Mfopou JK, Rooman I, Bouwens L. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 2005;48:49-57.","DOI":"10.1007\/s00125-004-1606-1"},{"key":"ref82","doi-asserted-by":"crossref","unstructured":"Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, Kawaguchi M, Ishizuka N, Iwanaga T, Seino S. Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. Proc Natl Acad Sci USA 2005;102:15116-15121.","DOI":"10.1073\/pnas.0507567102"},{"key":"ref83","doi-asserted-by":"crossref","unstructured":"Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008;455:627-632.","DOI":"10.1038\/nature07314"},{"key":"ref84","doi-asserted-by":"crossref","unstructured":"Solari MG, Srinivasan S, Boumaza I, Unadkat J, Harb G, Garcia-Ocana A, Feili-Hariri M. Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia. J Autoimmun 2009;32:116-124.","DOI":"10.1016\/j.jaut.2009.01.003"},{"key":"ref85","doi-asserted-by":"crossref","unstructured":"Ding Y, Xu D, Feng G, Bushell A, Muschel RJ, Wood KJ. Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9. Diabetes 2009;58:1797-1806.","DOI":"10.2337\/db09-0317"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Madec AM, Mallone R, Afonso G, Abou Mrad E, Mesnier A, Eljaafari A, Thivolet C. Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells. Diabetologia 2009;52:1391-1399.","DOI":"10.1007\/s00125-009-1374-z"},{"key":"ref87","doi-asserted-by":"crossref","unstructured":"Ferber S, Halkin A, Cohen H, Ber I, Einav Y, Goldberg I, Barshack I, Seijffers R, Kopolovic J, Kaiser N. Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia. Nat Med 2000;6:568-572.","DOI":"10.1038\/75050"},{"key":"ref88","doi-asserted-by":"crossref","unstructured":"Ber I, Shternhall K, Perl S, Ohanuna Z, Goldberg I, Barshack I, Benvenisti-Zarum L, Meivar-Levy I, Ferber S. Functional, persistent, and extended liver to pancreas transdifferentiation. J Biol Chem 2003;278:31950-31957.","DOI":"10.1074\/jbc.M303127200"},{"key":"ref89","doi-asserted-by":"crossref","unstructured":"Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med 2003;9:596-603.","DOI":"10.1038\/nm867"},{"key":"ref90","doi-asserted-by":"crossref","unstructured":"Kaneto H, Nakatani Y, Miyatsuka T, Matsuoka TA, Matsuhisa M, Hori M, Yamasaki Y. PDX-1\/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene transcription and ameliorates glucose tolerance. Diabetes 2005;54:1009-1022.","DOI":"10.2337\/diabetes.54.4.1009"},{"key":"ref91","doi-asserted-by":"crossref","unstructured":"Kaneto H, Matsuoka TA, Nakatani Y, Miyatsuka T, Matsuhisa M, Hori M, Yamasaki Y. A crucial role of MafA as a novel therapeutic target for diabetes. J Biol Chem 2005;280:15047-15052.","DOI":"10.1074\/jbc.M412013200"},{"key":"ref92","doi-asserted-by":"crossref","unstructured":"Noguchi H, Bonner-Weir S, Wei FY, Matsushita M, Matsumoto S. BETA2\/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence. Diabetes 2005;54:2859-2866.","DOI":"10.2337\/diabetes.54.10.2859"},{"key":"ref93","doi-asserted-by":"crossref","unstructured":"Noguchi H, Ueda M, Matsumoto S, Kobayashi N, Hayashi S. BETA2\/NeuroD protein transduction requires cell surface heparan sulfate proteoglycans. Hum Gene Ther 2007;18:10-17.","DOI":"10.1089\/hum.2006.118"},{"key":"ref94","doi-asserted-by":"crossref","unstructured":"Huang Y, Chen J, Li G, Cheng TY, Jiang MH, Zhang SY, Lu J, Yan S, Fan WW, Lu DR. Reversal of hyperglycemia by protein transduction of NeuroD in vivo. Acta Pharmacol Sin 2007;28:1181-1188.","DOI":"10.1111\/j.1745-7254.2007.00626.x"},{"key":"ref95","doi-asserted-by":"crossref","unstructured":"Domínguez-Bendala J, Klein D, Ribeiro M, Ricordi C, Inverardi L, Pastori R, Edlund H. TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro. Diabetes 2005;54:720-726.","DOI":"10.2337\/diabetes.54.3.720"}],"container-title":["World Journal of Stem Cells"],"original-title":[],"language":"en","deposited":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T17:47:01Z","timestamp":1634665621000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.wjgnet.com\/1948-0210\/full\/v1\/i1\/36.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009]]},"references-count":95,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.4252\/wjsc.v1.i1.36","relation":{},"ISSN":["1948-0210"],"issn-type":[{"value":"1948-0210","type":"print"}],"subject":[],"published":{"date-parts":[[2009]]}}}