{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:14:43Z","timestamp":1787494483372,"version":"build-2736575974"},"reference-count":52,"publisher":"Baishideng Publishing Group Inc.","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Stem Cells"],"abstract":"<jats:p>BACKGROUND<\/jats:p>\n                  <jats:p>Mesenchymal stem cells (MSCs) have protective effects on the cornea, lacrimal gland, retina, and photoreceptor cell damage, which may be mediated by exosomes (exos) released by MSCs.<\/jats:p>\n                  <jats:p>AIM<\/jats:p>\n                  <jats:p>To investigate the ameliorating effect of exos derived from different MSCs on retinal ganglion cell (RGC) injury induced by hydrostatic pressure.<\/jats:p>\n                  <jats:p>METHODS<\/jats:p>\n                  <jats:p>The RGC injury model was constructed by RGC damage under different hydrostatic pressures (40, 80, 120 mmHg). Then RGCs were cultured with adipose-derived stem cell (ADSC)-Exos and bone marrow-derived stem cell (BMSC)-Exos. Cell Counting Kit-8, transmission electron microscopy, flow cytometry, immunofluorescence, real-time quantitative polymerase chain reaction, and western blotting were performed to detect the ameliorating effect of exos on pressure-induced RGC injury.<\/jats:p>\n                  <jats:p>RESULTS<\/jats:p>\n                  <jats:p>ADSC-Exos and BMSC-Exos were successfully isolated and obtained. The gibbosity of RGCs was lower, the cells were irregularly ellipsoidal under pressure, and the addition of ADSC-Exos and BMSC-Exos significantly restored RGC morphology. Furthermore, the proliferative activity of RGCs was increased and the apoptosis of RGCs was inhibited. Moreover, the levels of lactate dehydrogenase and apoptosis-related proteins were increased, and the concentrations of antiapoptotic proteins and neurotrophic factors were decreased in damaged RGCs. However, the above indicators were significantly improved after ADSC-Exos and BMSC-Exos treatment.<\/jats:p>\n                  <jats:p>CONCLUSION<\/jats:p>\n                  <jats:p>These findings indicated that ADSC-Exos and BMSC-Exos could ameliorate RGC injury caused by hydrostatic pressure by inhibiting apoptosis and increasing the secretion of neurotrophic factors.<\/jats:p>","DOI":"10.4252\/wjsc.v15.i12.1077","type":"journal-article","created":{"date-parts":[[2023,12,25]],"date-time":"2023-12-25T00:54:56Z","timestamp":1703465696000},"page":"1077-1092","source":"Crossref","is-referenced-by-count":14,"title":["ADSC-Exos outperform BMSC-Exos in alleviating hydrostatic pressure-induced injury to retinal ganglion cells by upregulating nerve growth factors"],"prefix":"10.4252","volume":"15","author":[{"given":"Zhi-Kun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Dan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2017.0041"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34682-y"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3192"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02315-8"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2012.08.007"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.274349"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2010.514658"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-013-1646-2"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-3239"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-018-0069-y"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117303"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-02015-9"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121484"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2015.09.001"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.01.016"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/6901983"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2020.100849"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116733"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2147\/BTT.S290331"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140611692"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5078619"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22855"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18-25310"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.16-0428"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113224"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.01.022"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1159\/000490078"},{"key":"B28","unstructured":"Chan-Juan H, Sen L, Li-Qianyu A, Jian Y, Rong-Di Y. 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