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NAFLD and ALD have different triggers and their specific mechanisms of disease progression are different, but both involve disease processes such as hepatocellular steatosis and potential fibrosis, cirrhosis, and even hepatocellular carcinoma. MSCs have metabolic regulatory, anti-apoptotic, antioxidant, and immunomodulatory effects that together promote liver injury repair and functional recovery, and have demonstrated positive results in preclinical studies. This editorial is a continuum of Jiang et al \u2019s review focusing on the advantages and limitations of MSCs and their derivatives as therapeutics for NAFLD and ALD. They detail how MSCs attenuate the progression of NAFLD by modulating molecular pathways involved in glucolipid metabolism, inflammation, oxidative stress, endoplasmic reticulum stress, and fibrosis. Based on recent advances, we discuss MSCs and their derivatives as therapeutic strategies for NAFLD and ALD, providing useful information for their clinical application.<\/jats:p>","DOI":"10.4252\/wjsc.v16.i9.846","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T09:18:12Z","timestamp":1727083092000},"page":"846-853","source":"Crossref","is-referenced-by-count":6,"title":["Innovative mesenchymal stem cell treatments for fatty liver disease"],"prefix":"10.4252","volume":"16","author":[{"given":"Fei-Qiong","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Dong","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2060","published-online":{"date-parts":[[2024,9,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00759-2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.21037\/tgh-2019-nafld-15"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03125-1"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/stcltm\/szad082"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1322514"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v16.i7.760"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2021.04.003"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25460"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2020.03.012"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103962"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8326"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.11.012"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16338"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/stmcls\/sxac091"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02663-5"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3390\/cells11111829"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2014.04.017"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1393-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.trim.2023.101837"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01120-y"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-022-03201-7"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098092"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.08.037"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100746"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.11.012"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2022.2098583"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-021-00593-1"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114624"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2024.04.214"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.01.098"},{"key":"B32","unstructured":"Cai C, Chen DZ, Ge LC, Chen WK, Ye SS, Ye WW, Tao Y, Wang R, Li J, Lin Z, Wang XD, Xu LM, Chen YP. 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