{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:06:07Z","timestamp":1764115567599,"version":"3.46.0"},"reference-count":10,"publisher":"Baishideng Publishing Group Inc.","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["World J Stem Cells"],"abstract":"<jats:p>This article comments on the study by Fang, which demonstrates that reduced nuclear factor erythroid-derived 2 (NRF2) activity promotes endoplasmic reticulum stress and senescence in adipose-derived mesenchymal stem cells from hypertrophic obese mice, primarily through downregulation of mitofusin-2 (MFN2). Robust methodologies, including knockdown\/rescue experiments, chromatin immunoprecipitation quantitative polymerase chain reaction, co-immunoprecipitation, and transplantation assays, substantiate that NRF2 or MFN2 disruption impairs the therapeutic potential of these cells in insulin resistance. However, the proposed MFN2-binding immunoglobulin protein interaction remains indirectly supported and requires biochemical validation (e.g. , glutathione S-transferase pull-down\/Forster resonance energy transfer\/cross-linking mass spectrometry). Moreover, NRF2 may influence endoplasmic reticulum stress and senescence through additional unexplored targets. Future studies should clarify the structural and functional nature of the MFN2-binding immunoglobulin protein relationship and its implications for mitochondrial dynamics, endoplasmic reticulum-mitochondria tethering, and calcium signaling.<\/jats:p>","DOI":"10.4252\/wjsc.v17.i11.112476","type":"journal-article","created":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:59Z","timestamp":1764115259000},"source":"Crossref","is-referenced-by-count":0,"title":["Insights into mitofusin-2 and endoplasmic reticulum stress regulation in adipose-derived mesenchymal stem cells senescence"],"prefix":"10.4252","volume":"17","author":[{"given":"Fang","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2060","published-online":{"date-parts":[[2025,11,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v17.i6.104367"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.03.012"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s44161-024-00561-6"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.07.002"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.06.033"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102726"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.14348\/molcells.2023.0005"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101756"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.7150\/thno.65716"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-42521-x"}],"container-title":["World Journal of Stem Cells"],"original-title":[],"link":[{"URL":"https:\/\/www.wjgnet.com\/1948-0210\/full\/v17\/i11\/112476.htm","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.wjgnet.com\/1948-0210\/full\/v17\/i11\/112476.htm","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:01:07Z","timestamp":1764115267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.wjgnet.com\/1948-0210\/full\/v17\/i11\/112476.htm"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,26]]},"references-count":10,"journal-issue":{"issue":"11"},"alternative-id":["112476"],"URL":"https:\/\/doi.org\/10.4252\/wjsc.v17.i11.112476","relation":{},"ISSN":["1948-0210"],"issn-type":[{"value":"1948-0210","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11,26]]}}}